Abstract: A cover includes: divided covers, made of an elastomer; a first locking part, integrally formed on an edge of one divided cover; and a second locking part, integrally formed on an edge of the other divided cover. The first locking part includes a base end piece and a tip piece, and has a locking groove opening on a side opposite to an abutment direction formed between the base end piece and the tip piece. The second locking part includes a notch and a bridge. An insertion hole communicating with the notch is formed inside the bridge. By inserting the tip piece and the base end piece through the insertion hole and locking the bridge to the locking groove, the first locking part is locked to the second locking part while being prevented from coming off.

Abstract: A cover includes: divided covers, made of an elastomer; a first locking part, integrally formed on an edge of one divided cover; and a second locking part, integrally formed on an edge of the other divided cover. The first locking part includes a base end piece and a tip piece, and has a locking groove opening on a side opposite to an abutment direction formed between the base end piece and the tip piece. The second locking part includes a notch and a bridge. An insertion hole communicating with the notch is formed inside the bridge. By inserting the tip piece and the base end piece through the insertion hole and locking the bridge to the locking groove, the first locking part is locked to the second locking part while being prevented from coming off.

Abstract: The present invention aims to provide a method for dissociating cell aggregates, which are formed in cell culture, particularly in the cell passaging step, more easily and with less damage to cells, a method for culturing cells using said method, and a cell aggregate dissociation agent therefor. The present invention relates to a method for dissociating cell aggregates, including subjecting cell aggregates to a treatment with a water-insoluble metal ion adsorbent.

Abstract: The present invention relates to a technology for easy chemical modification of only one heavy chain in the constituent unit of an antibody (immunoglobulin unit containing two heavy chains and optionally two light chains). More particularly, the present invention relates to a compound or a salt thereof, containing (A) an affinity substance containing first and second affinity moieties each having an affinity to the constant region in a heavy chain of an antibody; and (B) a reactive group for the antibody.

Abstract: A method for secretory production of a protein containing a noncanonical amino acid is provided. Secretory production of a noncanonical amino acid-containing protein is carried out by culturing a coryneform bacterium having a genetic construct for secretory expression of a protein containing a noncanonical amino acid, which is modified to express an orthogonal pair of tRNA corresponding to the noncanonical amino acid and aminoacyl tRNA synthetase.

Abstract: A cover includes: divided covers, made of an elastomer; a first locking part, integrally formed on an edge of one divided cover; and a second locking part, integrally formed on an edge of the other divided cover. The first locking part includes a base end piece and a tip piece, and has a locking groove opening on a side opposite to an abutment direction formed between the base end piece and the tip piece. The second locking part includes a notch and a bridge. An insertion hole communicating with the notch is formed inside the bridge. By inserting the tip piece and the base end piece through the insertion hole and locking the bridge to the locking groove, the first locking part is locked to the second locking part while being prevented from coming off.

Abstract: A flame-retardant soundproof material for vehicles includes a polyurethane foam obtained by foam-molding a urethane resin composition. The urethane resin composition contains an isocyanate component (A), a polyol component (B), and an expandable graphite (C). The isocyanate component (A) includes a mixture of 2,4?-MDI and 4,4?-MDI, and one or more modified forms selected from carbodiimide modified forms and uretonimine modified forms of at least one of 2,4?-MDI and 4,4?-MDI. The content of the one or more modified forms in the urethane resin composition is 5.0 mass % to 8.8 mass %. The polyol component (B) includes a polyether polyol as a main constituent. The expandable graphite (C) has an expansion initiation temperature of 170° C. to 200° C., an expansion ratio of 10 or more at 250° C., and a content of 8 mass % to 20 mass % in the urethane resin composition.

Abstract: Provided is a quick and simple method for screening dimerized cyclic peptides, a library therefor, and molecules including cyclic peptides that can be used in the method and the library. For example, the method for screening dimerized cyclic peptides includes (1) a step in which, in a cell-free expression system, a cyclic peptide, a dimerization domain including a cysteine residue and a leucine zipper region, and at least one polypeptide including a peptide linker existing between the cyclic peptide and the dimerization domain are synthesized, and a dimer of the polypeptide is prepared, and (2) a step in which activity based on binding between the dimer and a target molecule is measured.

Abstract: A medium composition, containing a basic fibroblast growth factor (bFGF) at not less than 150 ng/mL is useful for culturing cells.

Abstract: Peptide-encapsulating ferritins including a peptide that is composed of 3 to 19 amino acid residues and satisfies the following requirement: a) ?10.2?X?5.

Abstract: Provided are a method for producing a complicated peptide molecule, such as a dimeric peptide, in a simpler manner at lower cost compared with the conventional chemical synthesis methods; and a dimeric peptide which comprises a specific short linker and has a satisfactory activity; and others.

Abstract: Provided is a recombinant activin A precursor protein that has human activin A activity. Also provided is a novel method for producing human activin A. The present invention pertains to a recombinant activin A precursor protein that includes a human mature activin A sequence and a non-human activin A prodomain, wherein said recombinant activin A precursor protein is not a naturally occurring activin A precursor protein. The present invention also pertains to a method for producing a human activin A using the aforesaid recombinant activin A precursor protein.

Abstract: The purpose of the present invention is to provide a cyclic peptide having any unit structure selected from the structures represented by the following formula (1): —X1—X2—X3—X4—X5—??(1) (in the formula (1), X1 is I, V or L, or an N-alkylamino acid thereof, X2 is S or T, or an N-alkylamino acid thereof, X3 is K or an N-alkylamino acid thereof, X4 is W or an N-alkylamino acid thereof, and X5 is W, Y, or H, or K or an N-alkylamino acid thereof), or a pharmaceutically acceptable salt of the cyclic peptide.

Abstract: An additive for culturing stem cells containing a polysaccharide other than dextran sulfate having a molecular weight of 4,000 kDa to 40,000 kDa, a medium for culturing stem cells, containing a polysaccharide other than dextran sulfate having a molecular weight of 4,000 kDa to 40,000 kDa, and a method for culturing a stem cell, including suspension culturing the stem cell in a medium for culturing stem cells containing a polysaccharide other than dextran sulfate having a molecular weight of 4,000 kDa to 40,000 kDa are useful for suspension culture of stem cells, in which the forming rate of cell aggregates of the stem cells can be improved, the shape thereof can be controlled, and also the proliferation rate and the rate of maintaining an undifferentiated state of the stem cells can be improved.

Abstract: Additives and media containing a water-soluble polymer are useful for suspension culture of animal cells, and can suppress the precipitation of medium components such as insulin 5 and the like due to physical stimulation of stirring, shaking, circulation, gas bubbling, or the like in suspension culture of animal cells, and can improve the culture efficiency of animal cells and the quality of cultured cells.

Abstract: Provided is a recombinant activin A precursor protein that has human activin A activity. Also provided is a novel method for producing human activin A. The present invention pertains to a recombinant activin A precursor protein that includes a human mature activin A sequence and a non-human activin A prodomain, wherein said recombinant activin A precursor protein is not a naturally occurring activin A precursor protein. The present invention also pertains to a method for producing a human activin A using the aforesaid recombinant activin A precursor protein.

Abstract: An inverter includes a power substrate mounting power element groups arranged apart from each other, each power element group constituted by power elements arranged, a control substrate disposed apart from the power substrate in a plate thickness direction of the power substrate and mounting an electronic component for controlling the power elements, a capacitor substrate disposed between the power substrate and the control substrate and mounting capacitors, a release member fixed to the power substrate, and a spacer electrically connecting the power substrate and the capacitor substrate. The spacer includes a body portion disposed between two adjacent power element groups of the power element groups and a heat transfer portion disposed outside the power element groups in a direction in which the power elements are arranged and provided at a position not overlapping with the capacitors as viewed in a plate thickness direction of the capacitor substrate.

Abstract: A semiconductor apparatus includes a heat release member, a first substrate that is fixed to the heat release member and on which a semiconductor device is mounted, a second substrate that is spaced from the first substrate in a thickness direction of the first substrate and on which an electronic component is mounted, and a bracket that fixes the second substrate to the heat release member. An electrically non-conductive heat transfer member is disposed between the second substrate and the bracket for transferring heat from the second substrate to the bracket. The bracket is made of a metal. The bracket includes a heat transfer portion that transfers heat to the heat release member.

Abstract: An inverter includes a power substrate mounting power element groups arranged apart from each other, each power element group constituted by power elements arranged, a control substrate disposed apart from the power substrate in a plate thickness direction of the power substrate and mounting an electronic component for controlling the power elements, a capacitor substrate disposed between the power substrate and the control substrate and mounting capacitors, a release member fixed to the power substrate, and a spacer electrically connecting the power substrate and the capacitor substrate. The spacer includes a body portion disposed between two adjacent power element groups of the power element groups and a heat transfer portion disposed outside the power element groups in a direction in which the power elements are arranged and provided at a position not overlapping with the capacitors as viewed in a plate thickness direction of the capacitor substrate.

Abstract: A peptide functioning as a c-Met agonist is described. A peptide complex comprising two or more peptides that bind to a c-Met protein and a linker that links the two or more peptides to one another is described. Such a peptide complex promotes autophosphorylation of the c-Met protein and induces cell growth.