Patents by Inventor Kenichiro Kiyoshima
Kenichiro Kiyoshima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230143246Abstract: Provided are a liquid preparation wherein the pharmaceutically active ingredient is stabilized, and a stabilizing method therefor. A liquid preparation comprising a pharmaceutically active ingredient having a primary or secondary amino group (wherein the amino group does not constitute a part of the amide structure), an organic acid and a salt, which is substantially free of a reaction product of the pharmaceutically active ingredient and the organic acid.Type: ApplicationFiled: December 16, 2022Publication date: May 11, 2023Inventors: Megumi Ikeda, Shohei Horiuchi, Tomomi Sato, Shinichiro Nakai, Kenichiro Kiyoshima
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Patent number: 9427434Abstract: The present invention provides a preparation containing pioglitazone or a salt thereof as an active ingredient, which shows high bioavailability of pioglitazone and less interindividual variation in blood drug concentration, as well as a preparation with suppressed color change during preservation. The preparation contains a core containing a pharmaceutically acceptable organic acid with water solubility at 20° C. of not less than 10 mg/mL and pKa1 (a negative common logarithm of the first acid dissociation constant Ka1) at 25° C. of not more than 5, and a coating layer containing pioglitazone or a salt thereof. The coating layer may further contain mannitol or trehalose.Type: GrantFiled: July 10, 2008Date of Patent: August 30, 2016Assignee: Takeda Pharmaceutical Company LimitedInventors: Hiroto Bando, Yoshihiro Omachi, Kenichiro Kiyoshima
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Publication number: 20150165027Abstract: Provided are a liquid preparation wherein the pharmaceutically active ingredient is stabilized, and a stabilizing method therefor. A liquid preparation comprising a pharmaceutically active ingredient having a primary or secondary amino group (wherein the amino group does not constitute a part of the amide structure), an organic acid and a salt, which is substantially free of a reaction product of the pharmaceutically active ingredient and the organic acid.Type: ApplicationFiled: June 26, 2013Publication date: June 18, 2015Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Megumi Ikeda, Shohei Horiuchi, Tomomi Sato, Shinichiro Nakai, Kenichiro Kiyoshima
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Publication number: 20150157619Abstract: The present invention provides a preparation for injection comprising a protein with a molecular weight of 20 kDa or greater and a pyridine derivative, wherein the preparation for injection does not comprise a hydrophobic preservative.Type: ApplicationFiled: July 9, 2013Publication date: June 11, 2015Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Kenichiro Kiyoshima, Shohei Horiuchi, Tomomi Sato, Megumi Ikeda
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Patent number: 8637079Abstract: A solid preparation containing compound (I), wherein the definition of compound (I) is as defined in the description, and pioglitazone, which is useful as a therapeutic drug for diabetes and the like and superior in the dissolution property, chemical stability and dissolution stability, is provided. A solid preparation containing the following first and second parts: (1) the first part containing compound (I) or a salt thereof and, as the first excipient, sugar or sugar alcohol; and (2) the second part containing pioglitazone or a salt thereof and, as the second excipient, sugar or sugar alcohol.Type: GrantFiled: January 30, 2008Date of Patent: January 28, 2014Assignee: Takeda Pharmaceutical Company LimitedInventors: Kenji Nakamura, Kenichiro Kiyoshima, Junya Nomura
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Patent number: 8071130Abstract: The present invention intends to provide a solid preparation which contains an insulin sensitizer and an active ingredient other than an insulin sensitizer, and exhibits dissolution behavior of an insulin sensitizer similar to that of an insulin sensitizer from “a solid preparation containing only an insulin sensitizer as an active ingredient”. The solid preparation comprises “a part containing coated particles in which the particles containing an insulin sensitizer are coated with lactose or a sugar alcohol” and “a part containing an active ingredient other than an insulin sensitizer”.Type: GrantFiled: December 21, 2006Date of Patent: December 6, 2011Assignee: Takeda Pharmaceutical Company LimitedInventors: Kenichiro Kiyoshima, Kenji Nakamura, Tetsuya Kawano, Masafumi Misaki
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Publication number: 20100166853Abstract: The present invention provides a preparation containing pioglitazone or a salt thereof as an active ingredient, which shows high bioavailability of pioglitazone and less interindividual variation in blood drug concentration, as well as a preparation with suppressed color change during preservation. The preparation contains a core containing a pharmaceutically acceptable organic acid with water solubility at 20° C. of not less than 10 mg/mL and pKa1 (a negative common logarithm of the first acid dissociation constant Ka1) at 25° C. of not more than 5, and a coating layer containing pioglitazone or a salt thereof. The coating layer may further contain mannitol or trehalose.Type: ApplicationFiled: July 10, 2008Publication date: July 1, 2010Inventors: Hiroto Bando, Yoshihiro Omachi, Kenichiro Kiyoshima
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Publication number: 20100092551Abstract: A solid preparation containing compound (I), wherein the definition of compound (I) is as defined in the description, and pioglitazone, which is useful as a therapeutic drug for diabetes and the like and superior in the dissolution property, chemical stability and dissolution stability, is provided. A solid preparation containing the following first and second parts: (1) the first part containing compound (I) or a salt thereof and, as the first excipient, sugar or sugar alcohol; and (2) the second part containing pioglitazone or a salt thereof and, as the second excipient, sugar or sugar alcohol.Type: ApplicationFiled: January 30, 2008Publication date: April 15, 2010Inventors: Kenji Nakamura, Kenichiro Kiyoshima, Junya Nomura
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Publication number: 20090028939Abstract: The present invention intends to provide a solid preparation which contains an insulin sensitizer and an active ingredient other than an insulin sensitizer, and exhibits dissolution behavior of an insulin sensitizer similar to that of an insulin sensitizer from “a solid preparation containing only an insulin sensitizer as an active ingredient”. The solid preparation comprises “a part containing coated particles in which the particles containing an insulin sensitizer are coated with lactose or a sugar alcohol” and “a part containing an active ingredient other than an insulin sensitizer”.Type: ApplicationFiled: December 21, 2006Publication date: January 29, 2009Inventors: Kenichiro Kiyoshima, Kenji Nakamura, Tetsuya Kawano, Masafumi Misaki
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Publication number: 20050267222Abstract: The present invention provides a composition containing a substance being capable of supplying aldehyde-like substances to be used in the field of medicaments, cosmetics, hair care products, etc., that contains a low-molecular weight active substance the stability of which is impaired by the effects of aldehydes and a stabilizer having an amine structure and being capable of absorbing aldehydes, and has an improved stability to aldehyde of said low-molecular weight active the stability of which is impaired by the effects of aldehydes substance; and a method for stabilizing such a low-molecular weight active substance. An example of said stabilizer is an aminosugar or a polymer thereof, an aminosugar alcohol or a polymer thereof, an amino acid or a polymer thereof, a protein or a hydrolysate thereof, an alkylamine, a hydroxyalkylamine, or a salt thereof.Type: ApplicationFiled: October 21, 2003Publication date: December 1, 2005Applicants: DAINIPPON PHARMACEUTICAL CO. LTD., TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Motokazu Iwata, Megumi Fujita, Hideo Kurita, Kenichiro Kiyoshima
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Patent number: 5726180Abstract: To stabilize the active ingredients, a caffeine is incorporated into a solid pharmaceutical preparation comprising a dextromethorphan and a phenylpropanolamine. The pharmaceutical preparation may further comprise ibuprofen. The active ingredients may be further stabilized, in combination with the incorporation of the caffeine, by grouping and incorporating separately each or suitably combined plural of the active ingredients into different groups or by minimizing the amount of any reducing sugar such as lactose. The solid pharmaceutical preparation is practically valuable since decomposition of each active ingredient with the lapse of time is remarkably suppressed and the active ingredients are stabilized for a longer period of time.Type: GrantFiled: October 30, 1996Date of Patent: March 10, 1998Assignee: Takeda Chemical Industries, Ltd.Inventors: Masahiko Kurihara, Shunichi Itoh, Kou Moriyama, Mitsutaka Isobe, Kenichiro Kiyoshima
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Patent number: 5629316Abstract: To stabilize the active ingredients, a caffeine is incorporated into a solid pharmaceutical preparation comprising a dextromethorphan and a phenylpropanolamine. The pharmaceutical preparation may further comprise ibuprofen. The active ingredients may be further stabilized, in combination with the incorporation of the caffeine, by grouping and incorporating separately each or suitably combined plural of the active ingredients into different groups or by minimizing the amount of any reducing sugar such as lactose. The solid pharmaceutical preparation is practically valuable since decomposition of each active ingredient with the lapse of time is remarkably suppressed and the active ingredients are stabilized for a longer period of time.Type: GrantFiled: June 28, 1994Date of Patent: May 13, 1997Assignee: Takeda Chemical Industries, Ltd.Inventors: Masahiko Kurihara, Shunichi Itoh, Kou Moriyama, Mitsutaka Isobe, Kenichiro Kiyoshima