Abstract: A cationic electrodeposition paint composition comprising a cationic base-containing resin (A), a blocked polyisocyanate compound (B), and a modified imidazole (C) having a specific structure, wherein the cationic base-containing resin (A) is a cationic base-containing epoxy resin and/or a cationic base-containing acrylic resin.

Abstract: This invention provides a cationic electrodeposition paint composition comprising an amino-group-containing epoxy resin (A), a blocked polyisocyanate compound (B), and a modified imidazole (C) having a specific structure, wherein the cationic electrodeposition paint composition satisfies the following (i) or (ii), or both: (i) the cationic electrodeposition paint composition further comprises a rust inhibitor (D) or (ii) a blocking agent (b-2) of the blocked polyisocyanate compound (B) is an oxime-based compound (b-2-1) and/or a pyrazole-based compound (b-2-2).

Abstract: An object of the present invention is to provide a convenient and low-cost method for enhancing the stability of a DNA aptamer and/or its capacity to bind to a target molecule, and a DNA aptamer obtained by the method. The object is solved by substituting an internal hairpin structure (stem-loop structure) of the DNA aptamer with a structure called mini-hairpin structure and optionally increasing GC pairs in a stem portion of the DNA aptamer.

Abstract: The purpose of the present invention is to provide an aptamer for vWF, which is superior in a binding ability, a dissociation rate, and/or stability to the conventional nucleic acid aptamers. The present invention can solve the problem by a DNA aptamer which contains artificial nucleotides and binds to vWF.

Abstract: A cationic electrodeposition paint composition comprising a cationic base-containing resin (A), a blocked polyisocyanate compound (B), and a modified imidazole (C) having a specific structure, wherein the cationic base-containing resin (A) is a cationic base-containing epoxy resin and/or a cationic base-containing acrylic resin.

Abstract: The present invention relates to a method for forming a multilayer coating film, the method comprising sequentially applying a colored coating composition (X), an effect pigment dispersion (Y), and a clear coating composition (Z) to a substrate to form an uncured colored coating film, an uncured effect coating film, and an uncured clear coating film, respectively, and heating the uncured colored coating film, the uncured effect coating film, and the uncured clear coating film to simultaneously cure these three coating films, thereby forming a multilayer coating film; wherein the effect pigment dispersion (Y) contains water, a specific surface modifier (A), a flake-effect pigment (B), and a viscosity modifier (C); and a film obtained by applying the effect pigment dispersion (Y) to a dry film thickness of 0.2 ?m has a light transmittance at a wavelength of 550 nm of 10 to 50%.

Abstract: An object of the present invention is to provide a convenient and low-cost method for enhancing the stability of a DNA aptamer and/or its capacity to bind to a target molecule, and a DNA aptamer obtained by the method. The object is solved by substituting an internal hairpin structure (stem-loop structure) of the DNA aptamer with a structure called mini-hairpin structure and optionally increasing GC pairs in a stem portion of the DNA aptamer.

Abstract: An object of the present invention is to provide a convenient and low-cost method for enhancing the stability of a DNA aptamer and/or its capacity to bind to a target molecule, and a DNA aptamer obtained by the method. The object is solved by substituting an internal hairpin structure (stem-loop structure) of the DNA aptamer with a structure called mini-hairpin structure and optionally increasing GC pairs in a stem portion of the DNA aptamer.

Abstract: An object of the present invention is to provide a convenient and low-cost method for enhancing the stability of a DNA aptamer and/or its capacity to bind to a target molecule, and DNA aptamer obtained by the method. The object is solved by substituting an internal hairpin structure (stem-loop structure) of the DNA aptamer with a structure called mini-hairpin structure and optionally increasing GC pairs in a stem portion of the DNA aptamer.

Abstract: The purpose of the present invention is to provide an aptamer for vWF, which is superior in a binding ability, a dissociation rate, and/or stability to the conventional nucleic acid aptamers. The present invention can solve the problem by a DNA aptamer which contains artificial nucleotides and binds to vWF.

Abstract: The present invention relates to a method for forming a multilayer coating film, the method comprising sequentially applying a colored coating composition (X), an effect pigment dispersion (Y), and a clear coating composition (Z) to a substrate to form an uncured colored coating film, an uncured effect coating film, and an uncured clear coating film, respectively, and heating the uncured colored coating film, the uncured effect coating film, and the uncured clear coating film to simultaneously cure these three coating films, thereby forming a multilayer coating film; wherein the effect pigment dispersion (Y) contains water, a specific surface modifier (A), a flake-effect pigment (B), and a viscosity modifier (C); and a film obtained by applying the effect pigment dispersion (Y) to a dry film thickness of 0.2 ?m has a light transmittance at a wavelength of 550 nm of 10 to 50%.