Abstract: The blood filter cartridge can filter almost total volume of drawn blood efficiently which comprises a blood filtering material and a holder containing the blood filtering material, wherein the holder is provided with a blood reservoir which connects with an inflow side of the blood filtering material and a filtrate receiver which connects with an outflow side of the blood filtering material.

Abstract: The blood filter cartridge of the invention can be used as a sample cup of an analyzer without sucking bubbles, which comprises a blood filtering material, a holder containing the blood filtering material and having a blood inlet and a filtrate outlet, and a filtrate receiver for receiving filtrate discharged from the filtrate outlet, the filtrate receiver has an upper end having a difference in height or structure for returning the filtrate from the upper end of the filtrate receiver to the filtrate outlet.

Abstract: This invention provides a blood filter unit capable of obtaining a necessary volume of a plasma or serum sample from blood to be assayed easily at any place, which comprises a blood filtering material and a holder accommodating the blood filtering material and having a nozzle for sucking blood and a filtrate outlet, and the inside of the holder being kept reduced pressure conditions.

Abstract: The invention provides a blood filter cartridge which is made so that the filtrate discharged from the filtrate outlet is not drawn back to the inside of the filtering chamber. The blood filter cartridge includes a blood filtering material, a holder containing the blood filtering material and having a blood inlet and a filtrate outlet, and a filtrate receiver which receives the filtrate discharged from the filtrate outlet. The blood filter catridge is provided with a means for preventing the filtrate in the filtrate receiver from returning to inside of the holder upon finishing filtration. Such means include the following: removing opposite faces around the filtrate outlet, making length of lower end of the filtrate outlet 0.8 mm or more, smoothing surface around the filtrate outlet, and forming surface around the filtrate outlet by a material having a small surface energy.

Abstract: The blood filter unit of the invention is composed of a blood filtering material made of glass fiber filter and microporous membrane and a holder having a blood inlet and a filtrate outlet. The holder accommodates the blood filtering material so that the microporous membrane is located on the filtrate outlet side, provides a space between the blood filtering material and the filtrate outlet, and provides a means for preventing adhesion of the blood filtering material on the filtrate outlet side. By using the blood filter unit, a necessary volume of plasma or serum for analysis can be separated surely, irrespective of hematocrit value of the blood.

Abstract: This invention provides a method of filtering blood using a filtering material comprising glass fiber filter, capable of obtaining a desired amount of plasma or serum without hemolysis and leakage of blood cells easily which comprises keeping pressure difference between blood inlet side and filtrate outlet side 50 mmHg or less at least for 5 seconds from contacting the blood to be filtered, and keeping the pressure difference 200 mmHg or less throughout the filtering of the blood.

Abstract: A blood filter unit having a blood filter holder containing a blood filtering material of a glass fiber filter and a microporous membrane is described. The holder has a blood inlet and a filtrate outlet, and accommodates the blood filtering material so that the microporous membrane is located on the filtrate outlet side and has a space between the blood filtering material and the filtrate outlet. The holder provides means for preventing adhesion of the blood filtering material on the filtrate outlet side. The inventive blood filter unit allows separation of a desired volume of plasma or serum for analysis without interference by the hematocrit value of the blood.

Abstract: The method of the invention is for preparing a plasma or serum sample from whole blood and includes mixing an aqueous solution of an inorganic salt or an amino acid or salt thereof with the whole blood in an amount of 20% or less of the whole blood volume so that concentration of the inorganic salt or the amino acid or salt thereof becomes 10 to 200 .mu.mol/1 ml whole blood, and then, filtering the whole blood to remove blood cell components. According to the method of the invention, plasma separation from whole blood can be achieved efficiently, and recovered volume of plasma can be increased. By selecting reagent, good plasma which has no deviation in component viewpoint, and which is possible to measure in the same level accuracy as a plasma obtained by centurifuging, can be obtained through a simple filtration operation.

Abstract: A spotting tip includes a tip body which is fitted on the end of a nozzle for sucking liquid contained in a container and inserted into the liquid in the container through a mouth of the container, and a lid member which is brought into contact with the mouth of the container and closes the space between the tip and the edge of the mouth when the tip is inserted into the container to a predetermined depth. At least one fine communicating passage is formed in at least one of the lid member and the tip body to communicate the inside and outside spaces of the container on opposite sides of the lid member.

Abstract: When determining an activity of particular predetermined ions in a sample liquid by use of a device for measuring ionic activity including a pair of ion-selective electrodes which are selectively responsive to particular predetermined ions, a pair of spotting holes through which a sample liquid and a reference liquid are respectively supplied to the ion-selective electrodes and a porous bridge which communicates the spotting holes with each other so as to permit the sample liquid and the reference liquid spotted to the spotting holes to electrically contact with each other, for instance, the sample liquid is first spotted to one of the spotting holes of the device for measuring ionic activity with a first spotting tool, and at least one of the first spotting tool and the device for measuring ionic activity is thereafter moved to remove the first spotting tool away from the device for measuring ionic activity.

Abstract: A method of using a chemical analysis slide which includes a slide frame and a sheet-like or film-like chemical analysis element for colorimetric determination of a specific component in an aqueous liquid sample, which method includesapplying an aqueous liquid sample to the chemical analysis element, andcovering the upper face of the side of the slide frame to which the sample is applied with a sheet-like, plate-like or block or brick-like cover to thereby ensure a space between the chemical analysis element and the cover and to prevent evaporation of water or to control evaporation rate of water.

Abstract: A method of using a chemical analysis slide comprising a slide frame and a sheet-like or film-like chemical analysis element for colorimetric determination of a specific component in an aqueous liquid sample, which comprisesapplying an aqueous liquid sample to the chemical analysis element, andcovering the upper face of the side of the slide frame to which the sample is applied with a sheet-like, plate-like or block or brick-like cover to thereby ensure a space between the chemical analysis element and the cover and to prevent evaporation of water or to control evaporation rate of water.

Abstract: A method for quantitative determination of bilirubin is disclosed. The method comprises bringing a bilirubin-containing aqueous liquid sample into contact with a hydrophobic bilirubin extracting composition containing a hydrophobic amine capable of extracting bilirubin. The amine extracts the bilirubin in said aqueous liquid sample. Photometry is then used to determine the concentration of bilirubin extracted with the bilirubin extracting composition. A device for use in this method is also disclosed. The device has a layer containing a hydrophobic bilirubin extracting composition containing a hydrophobic amine capable of extracting bilirubin.

Abstract: An analysis material sheet is disclosed which is comprised of layers of material with strong adhesion for one another. The sheet includes a water-impermeable support having provided directly or indirectly thereon a layer of fabric. The fabric contains a hydrophobic organic polymer fiber and is physically activated on at least one surface thereof, with the physically activated surface being adhered directly or indirectly to the support. A reagent layer can be provided directly or indirectly on the liquid sample-spreading layer of fabric. By utilizing a fabric containing a hydrophobic organic polymer fiber, body fluids to be analyzed can be quickly and uniformly spread and by utilizing the physically activated surface of the fabric, strong adhesion between the layers can be obtained.

Abstract: A multilayer chemical analytical element is employable in quantitative analysis of analyte in a biological fluid such as blood. The element consists of a porous spreading layer, a light-blocking layer and a reagent layer on a water-impermeable light-transmissive support in order. The light-blocking layer contains a titanium dioxide fine powder with no provision of aluminum oxide compound or silicon oxide.

Abstract: A device for maintaining a constant temperature for chemical analysis performed with slides having at least one layer adapted to absorb a substance to be analyzed. The slides are conveyed upon a lower conveying belt which may have projections or recesses formed therein for receiving the slides. The upper portions of the slides are sealed by a sealing guide belt which has a surface disposed parallel to and adjacent the conveying belt with the slides passing therebetween. A heater may be provided within the conveying belt and the guide member provided within the sealing guide belt which may itself perform a heating function.

Abstract: A method for quantitative determination of bilirubin is disclosed. The method comprises bringing a bilirubin-containing aqueous liquid sample into contact with a hydrophobic bilirubin extracting composition containing a hydrophobic amine capable of extracting bilirubin. The amine extracts the bilirubin in said aqueous liquid sample. Photometry is then used to determine the concentration of bilirubin extracted with the bilirubin extracting composition. A device for use in this method is also disclosed. The device has a layer containing a hydrophobic bilirubin extracting composition containing a hydrophobic amine capable of extracting bilirubin.

Abstract: A chemical analyzer in which a component of a material to be analyzed acts on a coloring (dye forming) reagent in a reagent layer of the multi-layer type chemical analysis slide. The material to be analyzed is then maintained at a constant temperature for a predetermined period of time, after which the degree of coloration thereof is measured optically so that predetermined parameters of the material are measured with a very high accuracy. A conveying mechanism conveys the chemical analysis slides along an analysis path between two stationary temperature control plates. A first one of the plates having a cut therein has a heating element buried therein extending throughout the plate. The opposed plate has a heating element extending into regions not opposed by the cut in the first plate. The second plate has plural openings through which an irradiating light beam from a light source of a photometric mechanism and a reflection light beam from slides positioned over the openings pass.

Abstract: A chemical analysis slide frame assembly including first and second slide frames each having an opening whose area is smaller than the area of a chemical analysis film inserted therein and a third slide frame disposed between the first and second slide frames. The third slide frame has an opening which is adapted to receive the chemical analysis film and is shaped so as to substantially prevent the displacement of the chemical analysis film. The third slide frame has a thickness which is equal to or larger than the thickness of the chemical analysis film. The side wall of the opening in the first slide frame has a small optical reflection factor, preferably is dark so as to provide a small optical reflection factor.

Abstract: In a photoresist material comprising a support having formed thereon a layer of a photopolymerizable composition comprising a film forming polymer, a monomer having at least one addition polymerizable unsaturated bond, and a photopolymerization initiator, the adhesive property and the light-sensitivity of the layer of the photopolymerizable composition are improved by incorporating a rosin tackifier in the layer.