Abstract: The present invention provides a novel combination therapy with PD-1 blockade therapy. A pharmaceutical composition which comprises a substance capable of enhancing T cell receptor (TCR) signaling and is administered before, after or simultaneously with the administration of a PD-1 signaling inhibitor. A drug which enhances PD-1 signaling inhibitory activity, comprising a CD45 inhibitor and/or a cell. A TCR signaling enhancer comprising a CD45 inhibitor and/or a cell.

Abstract: A frequency abnormality detecting circuit for detecting the frequency abnormality of an AC power source, comprises a waveform shaping circuit for shaping an output waveform (detection waveform) of the AC power source, which is an object to be detected; a frequency demultiplier for demultiplying an output of the waveform shaping circuit at least by one period of the dection waveform; a counter for counting an output pulse of a reference oscillator by the leading edge of an output pulse of the demultiplier; a memory circuit such as a read only memory (ROM) for storing bit data using output data of the counter as an address; an OR gate for performing an OR operation of an output of the memory circuit; a switch device for inputting the output of the memory circuit into the OR gate; and a flip-flop for operating in synchronism with the output pulse of the frequency demultiplier using an output of the OR gate as data input.

Abstract: An inverter control circuit for a power supply source comprising an inverter and a commercial power source (reserve power source) and adapted to connect the inverter normally to a load and to change the inverter with the commercial power source uninterruptedly by means of a thyristor switch to supply power uninterruptedly to the load in case the inverter malfunctions. The inverter control circuit comprises a digital PLL circuit for synchronism control, a bias signal, and a parallel connection of a synchronism control circuit and a synchronism detecting circuit, and is capable of uniterruptedly changing the inverter to the commercial power source by being switched to biasing signals by means of the switch at the timing of the synchronism detecting of the synchronism detecting circuit in case the synchronism control circuit malfunctions.

Abstract: An inverter control system for selectively operating on one of an inverter and backup power source to supply a load current comprises a PLL circuit which includes an integrating amplifier and is operative to synchronize the inverter operation with the voltage of the backup power source. When the power supply to the load is switched from the backup power source to the inverter, a.c. switches for the switching operation are controlled so that both the backup power source and inverter are active simultaneously for a certain period, and during the parallel operation the integrating amplifier is supplied with a reference signal which operates on the inverter to increase its shared load current.