Patents by Inventor Kenji Kangawa
Kenji Kangawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20020086843Abstract: A physiologically active polypeptide derived from human brain and a DNA fragment comprising the base sequence encoding the polypeptide are disclosed. The polypeptide possesses excellent smooth muscle relaxation activity, diuretic or natriuretic activity, and vasodepressor activity, and is thus useful as a medicine for curing circulation diseases, e.g. cardiac edema, nephric edema, hepatic edema, pulmonary edema, hypertension, congestive heat failure, and acute and chronic renal failure.Type: ApplicationFiled: July 11, 2001Publication date: July 4, 2002Applicant: Daiichi Pure Chemicals Co., Ltd.Inventors: Tetsuji Sudoh, Keiji Maekawa, Naoto Minamino, Kenji Kangawa, Hisayuki Matsuo, Atsushi Izumi, Mika Takashima
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Patent number: 6020168Abstract: The gene and cDNA of a procine derived CNP (C-type natriuretic peptide), and a procine derived CNP precursor protein and derivatives thereof are disclosed. The proceine derivative CNP precursor is represented by the following amino acid sequence:Met His Leu Ser Gln Leu Leu Ala Cys Ala - Leu Leu Leu Thr Leu Leu Ser Leu Arg Pro - Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys - Val Pro Arg Thr Pro Pro Gly Glu Glu Val - Ala Glu Pro Gln Ala Ala Gly Gly Gly Gln - Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly - Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg - Leu Leu Arg Asp Leu Arg Val Asp Thr Lys - Ser Arg Ala Ala Trp Ala Arg Leu Leu His - Glu His Pro Asn Ala Arg Lys Tyr Lys Gly - Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys - Phe Gly Leu Lys Leu Asp Arg Ile Gly SerThese derivatives are novel and have natriuretic and hypotensive activities.Type: GrantFiled: July 12, 1991Date of Patent: February 1, 2000Assignees: Suntory Limited, Hisayuki MatsuoInventors: Hisayuki Matsuo, Kenji Kangawa, Naoto Minamino, Shoji Tanaka, Kayoko Fuchimura, Yasunori Tawaragi
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Patent number: 5973134Abstract: A cDNA coding for a rat derived CNP (rCNP: C-type natriuretic pepteide), and a rat derived CNP precursor protein and derivatives thereof are disclosed.The rat derived CNP precursor is represented by the following amino acid sequence.Met His Leu Ser Gln Leu Ile Ala Cys Ala Leu Leu Leu Ala Leu Leu Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Thr Pro Pro Lys Val Pro Arg Thr Pro Pro Gly Glu Glu Leu Ala Glu Pro Gln Ala Ala Gly Gly Asn Gln Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu His Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly CysThe rCNP precursor and its derivatives are novel and have natriuretic and hypotensive activities.Type: GrantFiled: September 11, 1991Date of Patent: October 26, 1999Assignees: Suntory Limited, Hasayuki MatsuoInventors: Hisayuki Matsuo, Masayasu Kojima, Kenji Kangawa, Naoto Minamito
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Patent number: 5910416Abstract: Adrenomedullin which is a novel peptide having a hypotensive effect; proadrenomedullin N-terminal 20 peptide (proAM-N20) corresponding to an amino acid sequence of an N-terminus of proadrenomedullin, having a catecholamine secretion inhibitory effect; proadrenomedullin N-terminal 10-20 peptide (proAM-N(10-20)) having a Na channel inhibitory effect, and a gene encoding these peptides are provided. In addition, according to the present invention, these peptides in a sample containing adrenomdullin or proAM-N20 in an unknown amount can be quantified by using an antibody against adrenomedullin, proAM-N20, or its fragment.Type: GrantFiled: January 7, 1998Date of Patent: June 8, 1999Assignees: Shionogi & Co., Ltd., Kenji KangawaInventors: Kazuo Kitamura, Kenji Kangawa, Hisayuki Matsuo, Tanenao Eto
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Patent number: 5837823Abstract: According to the present invention, adrenomedullin which is a novel peptide having a hypotensive effect; proadrenomedullin N-terminal 20 peptide (proAM-N20) corresponding to an amino acid sequence of an N-terminus of proadrenomedullin, having a catecholamine secretion inhibitory effect; proadrenomedullin N-terminal 10-20 peptide (proAM-N(10-20)) having a Na channel inhibitory effect, and a gene encoding these peptides are provided. In addition, according to the present invention, these peptides in a sample containing adrenomdullin or proAM-N20 in an unknown amount can be quantified by using an antibody against adrenomedullin, proAM-N20, or its fragment.Type: GrantFiled: June 7, 1995Date of Patent: November 17, 1998Assignees: Shinonogi & Co., Ltd., Kenji KangawaInventors: Kazuo Kitamura, Kenji Kangawa, Hisayuki Matsuo, Tanenao Eto
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Patent number: 5830703Abstract: According to the present invention, adrenomedullin which is a novel peptide having a hypotensive effect; proadrenomedullin N-terminal 20 peptide (proAM-N20) corresponding to an amino acid sequence of an N-terminus of proadrenomedullin, having a catecholamine secretion inhibitory effect; proadrenomedullin N-terminal 10-20 peptide (proAM-N(10-20)) having a Na channel inhibitory effect, and a gene encoding these peptides are provided. In addition, according to the present invention, these peptides in a sample containing adrenomdullin or proAM-N20 in an unknown amount can be quantified by using an antibody against adrenomedullin, proAM-N20, or its fragment.Type: GrantFiled: February 18, 1997Date of Patent: November 3, 1998Assignees: Shionogi & Co., Ltd., Kenji KangawaInventors: Kazuo Kitamura, Kenji Kangawa, Hisayuki Matsuo, Tanenao Eto
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Patent number: 5639855Abstract: According to the present invention, adrenomedullin which is a novel peptide having a hypotensive effect; proadrenomedullin N-terminal 20 peptide (proAM-N20) corresponding to an amino acid sequence of an N-terminus of proadrenomedullin, having a catecholamine secretion inhibitory effect; proadrenomedullin N-terminal 10-20 peptide (proAM-N(10-20)) having a Na channel inhibitory effect, and a gene encoding these peptides are provided. In addition, according to the present invention, these peptides in a sample containing adrenomedullin or proAM-N20 in an unknown amount can be quantified by using an antibody against adrenomedullin, proAM-N20, or its fragment.Type: GrantFiled: April 26, 1994Date of Patent: June 17, 1997Assignees: Shionogi & Co., Ltd., Kenji KangawaInventors: Kazuo Kitamura, Kenji Kangawa, Hisayuki Matsuo, Tanenao Eto
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Patent number: 5354900Abstract: There are disclosed a new peptide .alpha.-hANP of the following structure: ##STR1## and acid addition salt thereof; a diuretic composition and a hypotensor composition containing the .alpha.-hANP or an acid addition salt thereof; and processes for the production thereof.Type: GrantFiled: December 21, 1984Date of Patent: October 11, 1994Assignees: Suntory Limited, Hisayuki MatsuoInventors: Hisayuki Matsuo, Kenji Kangawa
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Patent number: 5340920Abstract: A peptide composed of 53 amino acid residues represented by the following amino acid sequence: (see SEQ ID NO: 1) ##STR1## and derivatives thereof represented by the following amino acid sequence: (see SEQ ID NO: 2) ##STR2## wherein X is as shown in the specification, are disclosed. These polypeptides are novel and have natriuretic and hypotensive actions.Type: GrantFiled: July 12, 1991Date of Patent: August 23, 1994Assignee: Hisayuki MatsuoInventors: Hisayuki Matsuo, Kenji Kangawa, Naoto Minamino
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Patent number: 5338830Abstract: A novel peptide that exhibits a natriuretic action and a vasodepressor activity, and hence, that is applicable as a diagnostic reagent. The novel peptide is manufactured by the procedure of genetic engineering as well as by the methods of purification from chicken brains or by chemical synthesis.Type: GrantFiled: September 4, 1991Date of Patent: August 16, 1994Assignees: Suntory Limited, Hisayuki MatsuoInventors: Hisayuki Matsuo, Kenji Kangawa, Naoto Minamino
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Patent number: 5336759Abstract: A novel peptide that exhibits a natriuretic action and a vasodepressor activity, and hence, that is applicable for a diagnostic reagent. The novel peptide is manufactured by tile procedure of genetic engineering as well as by the methods of purification from frog brains or by chemical synthesis.Type: GrantFiled: September 4, 1991Date of Patent: August 9, 1994Assignees: Suntory Limited, Hisayuki MatsuoInventors: Hisayuki Matsuo, Kenji Kangawa, Naoto Minamino
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Patent number: 5118615Abstract: Disclosed is a DNA fragment comprising a base sequence coding for a peptide occurring in human atrium cordis and having diuretic action or a precursor of the peptide, plasmids containing the DNA fragment, microorganisms transformed with the plasmid, and a process for production of the peptide using the transformant.Also disclosed is a new peptide consisting of 126 amino acids occurring in human atrium cordis and a precursor thereof. The peptide has notable diuretic action and hypotensive or antihypertensive actions.Type: GrantFiled: March 9, 1987Date of Patent: June 2, 1992Assignee: Suntory LimitedInventors: Hisayuki Matsuo, Kenji Kangawa, Yujiro Hayashi, Shinzo Oikawa, Takehiro Oshima, Shoji Tanaka, Hiroshi Nakazato, Yasunori Tawaragi
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Patent number: 4904763Abstract: Disclosed herein is a physiologically-active peptide represented by the following general formula (I): ##STR1## wherein X means H or H-Asp-Ser-Gly- and Y denotes -Asn-Val-Leu-Arg-Arg-Tyr-OH, -Asn-Val-Leu-Arg-Arg-OH, -Asn-Val-Leu-Arg-Tyr-OH, -Asn-Val-Leu-Arg-OH, -Asn-Val-Leu-OH or -Asn-Ser-Phe-Arg-Tyr-OH, or a salt thereof.Type: GrantFiled: June 17, 1988Date of Patent: February 27, 1990Assignees: Daiichi Pure Chemicals Co., Ltd., Hisayuki MatsuoInventors: Hisayuki Matsuo, Kenji Kangawa, Naoto Minamino, Tetsuji Sudoh, Atsushi Izumi, Mitsutaka Isogai
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Patent number: 4748232Abstract: There are disclosed a new peptide .alpha.-hANP of the following structure: ##STR1## and acid addition salt thereof; a diuretic composition and a hypotensor composition containing the .alpha.-hANP or an acid addition salt thereof; and processes for the production thereof.Type: GrantFiled: September 11, 1986Date of Patent: May 31, 1988Assignees: Suntory Limited, Hisayuki MatsuoInventors: Hisayuki Matsuo, Kenji Kangawa
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Patent number: 4657891Abstract: There are disclosed a new peptide .beta.-rANP of the following structure: ##STR1## and acid addition salt thereof; a diuretic composition and a hypotensor composition containing the .beta.-rANP or an acid addition salt thereof; and processes for the production thereof.Type: GrantFiled: February 27, 1985Date of Patent: April 14, 1987Assignees: Suntory Limited, Hisayuki MatsuoInventors: Hisayuki Matsuo, Kenji Kangawa
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Patent number: 4656158Abstract: There are disclosed a new peptide .beta.-hANP of the following structure: ##STR1## and acid addition salt thereof; a diuretic composition and a hypotensor composition containing a .beta.-hANP or an acid addition salt thereof; and processes for the production thereof.Type: GrantFiled: February 27, 1985Date of Patent: April 7, 1987Assignees: Suntory Limited, Hisayuki MatsuoInventors: Hisayuki Matsuo, Kenji Kangawa