Abstract: A grip comprises a grip body forming a gripping control portion of a manually operable device to be held with the operator's palm and fingers. The grip body includes a ball-receiving surface coming into contact with the ball of the thumb, a palm-receiving surface coming into contact with a middle portion of the palm and the ball of the little finger, a finger-receiving surface coming into contact with the fingers, an open surface positioned between the tips of the fingers and the ball of the thumb for receiving the thumb when the grip body is held, and a switch mounted on a top portion of the grip body to be operable with the thumb.

Abstract: There is provided a magnetic particle to which a large amount of target substance can bind upon separation, analysis and the like of the target substance, the particle exhibiting a higher rate of the magnetic separation. The magnetic particle to which a target substance can bind, comprising a core particle having magnetism and a polymer coat layer comprising a polymer shell portion in which a rough coating of polymer is provided on a surface of the core particle. This magnetic particle has a roughness due to a surface roughness of the polymer shell portion wherein a specific surface area (m2/g) of the magnetic particle is 1.5 to 500 times a specific surface area (m2/g) of the core particle when the core particle is regarded as a smooth perfect sphere.

Abstract: The particle of the present invention is a high-density particle to which a target substance can be bound, wherein the surface of the particle body is a roughened surface. The particle is characterized in that a substance or functional group to which a target substance can bind is immobilized on the roughened surface of the particle body, and the specific surface area of the particle is 1.4 to 100 times the specific surface area of a true spherical particle having the same particle size and the same density as those of the particle of the invention. In the particle of the invention, the accumulated micropore volume [cm3] of micropores having radius of not less than 20 nm per unit surface area [cm2] is not less than 1×10?6 [cm3/cm2].

Abstract: A method for dicing a semiconductor substrate includes: forming a reforming layer in the substrate by irradiating a laser beam on the substrate; forming a groove on the substrate along with a cutting line; and applying a force to the substrate in order to cutting the substrate at the reforming layer as a starting point of cutting. The groove has a predetermined depth so that the groove is disposed near the reforming layer, and the force provides a stress at the groove.

Abstract: A grip comprises a grip body forming a gripping control portion of a manually operable device to be held with the operator's palm and fingers. The grip body includes a ball-receiving surface coming into contact with the ball of the thumb, a palm-receiving surface coming into contact with a middle portion of the palm and the ball of the little finger, a finger-receiving surface coming into contact with the fingers, an open surface positioned between the tips of the fingers and the ball of the thumb for receiving the thumb when the grip body is held, and a switch mounted on a top portion of the grip body to be operable with the thumb.

Abstract: The present invention provides a hairless transgenic nonhuman animal used in the development of a therapy for dermatitis such as human atopic dermatitis and drug discovery. Specifically, the present invention provides a transgenic nonhuman animal, into which recombinant DNA comprising a heparin-binding EGF gene and a type 2 keratin gene promoter for regulating expression of the above gene has been introduced.

Abstract: We prepared a transgene comprising human HB-EGF precursor cDNA, as a diphtheria toxin receptor gene, at the downstream of an insulin promoter, and introduced this transgene into a mouse fertilized egg, to produce a transgenic mouse of the present invention. In this mouse, human HB-EGF precursors are expressed specifically in islet beta cells, and by injection of diphtheria toxin, islet beta cells are selectively destroyed, resulting in that the mouse shows diabetes two or three days after the injection. This mouse can be utilized in screening and development of new medicines and therapy protocols for diabetes.

Abstract: An infrared fluorescent particle comprising a functional group or a substance that is capable of binding to an analyte, wherein fluorescence at infrared wavelength is emitted from the particle upon exposure of the particle to excitation light at infrared wavelength. The infrared fluorescent particle of the present invention is capable of binding to the analyte. Due to a high penetration of the fluorescence and the excitation light into biological substances, the infrared fluorescent particle of the present invention can reduce an influence of luminescence, light absorption or light scattering which is occurred due to the analyte and the surrounding substances.

Abstract: The present invention relates to a diabetes animal model. Specifically, the present invention relates to a transgenic nonhuman animal, into which recombinant DNA comprising a gene encoding a diphtheria toxin receptor and an insulin promoter for regulating expression of the above gene has been introduced.

Abstract: The aim of this invention is to offer a novel agent for hair growth, which has excellent hair growth effects but not side effects. The agent for hair growth of the present invention is characterized by comprising a processed semi-mature soybean and/or a processed semi-mature soybean extracts and at least one substance selected from the group consisting of a processed Polygoni Multiflori Radix, processed Polygoni Multiflori Radix extracts, a processed Cynanchum bungei Decne or processed Cynanchum bungei Decne extracts, preferably further comprising Longan seed and/or Longan seed extracts as active ingredients. This agent for hair growth has no side effects when used externally or internally, it can notably improve hair growth within a short period of time; ranging from 6 to 12 weeks, can return hair to its normal hair colour (for example from white to black) and can improve the gloss of hair.

Abstract: The particles of the present invention are high density particles which enable a preferential binding of a target substance thereto and inhibit a binding of “substances other than the target substance” thereto. The particles of the present invention are characterized in that a substance or functional group capable of binding to a target substance is immobilized on the surface of a particle body; the particles have a density of 3.5 g/cm3 to 9.0 g/cm3 and the particle body has no through-pore. The particles of the present invention are also characterized by a specific surface area of 0.0005 m2/g to 1.0 m2/g.

Abstract: We prepared a transgene comprising human HB-EGF precursor cDNA, as a diphtheria toxin receptor gene, at the downstream of an insulin promoter, and introduced this transgene into a mouse fertilized egg, to produce a transgenic mouse of the present invention. In this mouse, human HB-EGF precursors are expressed specifically in islet beta cells, and by injection of diphtheria toxin, islet beta cells are selectively destroyed, resulting in that the mouse shows diabetes two or three days after the injection. This mouse can be utilized in screening and development of new medicines and therapy protocols for diabetes.

Abstract: An infrared fluorescent particle comprising a functional group or a substance that is capable of binding to an analyte, wherein fluorescence at infrared wavelength is emitted from the particle upon exposure of the particle to excitation light at infrared wavelength. The infrared fluorescent particle of the present invention is capable of binding to the analyte. Due to a high penetration of the fluorescence and the excitation light into biological substances, the infrared fluorescent particle of the present invention can reduce an influence of luminescence, light absorption or light scattering which is occurred due to the analyte and the surrounding substances.

Abstract: An infrared fluorescent particle comprising a functional group or a substance that is capable of binding to an analyte, wherein fluorescence at infrared wavelength is emitted from the particle upon exposure of the particle to excitation light at infrared wavelength. The infrared fluorescent particle of the present invention is capable of binding to the analyte. Due to a high penetration of the fluorescence and the excitation light into biological substances; the infrared fluorescent particle of the present invention can reduce an influence of luminescence, light absorption or light scattering which is occurred due to the analyte and the surrounding substances.

Abstract: The present invention provides composite particles which have magnetism and simultaneously emit fluorescence with a variety of wavelengths, and which are suitable for use in the fields of biology, biochemistry or the like. The composite particles of the present invention comprise ferromagnetic iron oxide particles, fluorescent pigment particles and silica, and have an average particle size of 1 to 10 ?m, a coercive force of 2.39 to 11.94 kA/m (30 to 150 oersted), saturation magnetization of 0.5 to 40 A.m2/kg (0.5 to 40 emu/g). The peak value of the wavelength of fluorescence from the composite particle is in the range of 350 to 750 nm, when the composite particle is excited by light with a wavelength of 250 to 600 nm.

Abstract: An infrared fluorescent particle comprising a functional group or a substance that is capable of binding to an analyte, wherein fluorescence at infrared wavelength is emitted from the particle upon exposure of the particle to excitation light at infrared wavelength. The infrared fluorescent particle of the present invention is capable of binding to the analyte. Due to a high penetration of the fluorescence and the excitation light into biological substances; the infrared fluorescent particle of the present invention can reduce an influence of luminescence, light absorption or light scattering which is occurred due to the analyte and the surrounding substances.

Abstract: A method for dicing a semiconductor substrate includes: forming a reforming layer in the substrate by irradiating a laser beam on the substrate; forming a groove on the substrate along with a cutting line; and applying a force to the substrate in order to cutting the substrate at the reforming layer as a starting point of cutting. The groove has a predetermined depth so that the groove is disposed near the reforming layer, and the force provides a stress at the groove.

Abstract: An ink jet-printing medium comprising a substrate and an ink-receptive layer which has at least one layer and is formed on at least one major surface of the substrate, in which at least one layer of the ink-receptive layer contains fibrous fine powder as a pigment in an amount of at least 20% by weight of the total weight of the whole pigment contained in the layer which contains the fibrous fine powder. This medium can be produced at a low cost and has high printing quality while suppressing the discoloration or fading of the prints.

Abstract: An object of the present invention is to provide a nonaqueous electrolyte battery which restrains swelling of the battery during high-temperature storage and is excellent in battery performance after storage. The invention is characterized by a specific constitution of a nonaqueous electrolyte and a combination thereof with a positive active material having specific crystal structure and composition. Namely, it is characterized by a nonaqueous electrolyte battery containing a positive electrode, a negative electrode, and a nonaqueous electrolyte, wherein the above nonaqueous electrolyte contains at least a cyclic carbonate having a carbon-carbon ? bond and the above positive electrode contains a positive active material comprising a composite oxide represented by a composite formula: LixMnaNibCOcO2 (wherein 0?x?1.1, a+b+c=1, |a-b|<0.05, 0<c<1) and having an ?-NaFeO2-type crystal structure.

Abstract: The present invention provides composite particles which have magnetism and simultaneously emit fluorescence with a variety of wavelengths, and which are suitable for use in the fields of biology, biochemistry or the like. The composite particles of the present invention comprise ferromagnetic iron oxide particles, fluorescent pigment particles and silica, and have an average particle size of 1 to 10 ?m, a coercive force of 2.39 to 11.94 kA/m (30 to 150 oersted), saturation magnetization of 0.5 to 40 A.m2/kg (0.5 to 40 emu/g). The peak value of the wavelength of fluorescence from the composite particle is in the range of 350 to 750 nm, when the composite particle is excited by light with a wavelength of 250 to 600 nm.