Abstract: Provided is a novel additive for an orally disintegrating tablet providing quick disintegrability and tablet hardness to the orally disintegrating tablet, and a producing method therefor. According to an embodiment of the present invention, there is provided an additive for an orally disintegrating tablet characterized by including D-mannitol, low-substituted hydroxypropyl cellulose (however, excluding the low-substituted hydroxypropyl cellulose having a mean particle size of 20 ?m or less and a substitution degree of hydroxypropoxy groups of 11%, a mean particle size of 45 ?m or less and a substitution degree of hydroxypropoxy groups of 14%, and a mean particle size of 45 ?m or less and a substitution degree of hydroxypropoxy groups of 11% and a 90% cumulated particle size of 100 ?m or less), crospovidone, and microcrystalline cellulose, wherein the low-substituted hydroxypropyl cellulose and the crospovidone are included in a ratio of 5:4.

Abstract: An application apparatus includes a first roller configured to apply a treatment liquid to a recording medium conveyed; and a second roller disposed in contact with the first roller and forming, with the first roller, a conveyance nip in which the recording medium is nipped. The application apparatus further includes a third roller disposed in contact with the first roller at a position different from the conveyance nip, and a fourth roller disposed in contact with the second roller at a position different from the conveyance nip. The third roller has a rigidity higher than a rigidity of the first roller, and the fourth roller has rigidity higher than a rigidity of the second roller.

Abstract: A method for producing granules containing a core particle by using a general granulation method is provided. Granules containing a core particle produced by the method are provided. In addition, a pharmaceutical composition and preparation containing the granules containing the core particle are provided. The granulation method according to an embodiment of the present invention granulates by splaying granulation liquid having a mist diameter (D50) not more than the particle size (D50) of the core particle on a mixture containing a drug substance and a core particle. The granulation liquid may be water. The particle size of the core particle (D50) may be larger than the particle size (D50) of the drug substance.

Abstract: A heating device includes a heat irradiator configured to heat a sheet on which a liquid is applied and is conveyed in a conveyance direction, an ultraviolet irradiator on a downstream of the heat irradiator in the conveyance direction, the ultraviolet irradiator configured to heat a portion of the sheet, and a circuitry configured to control an output of the heat irradiator and an output of the ultraviolet irradiator based on a thickness of the sheet.

Abstract: A heating device includes a conveyor configured to convey a sheet onto which a liquid is applied in a conveyance direction, an irradiator including a light emitter on an irradiation surface of the irradiator, the light emitter configured to emit light onto the sheet to heat the sheet with the light, a channel plate between the conveyor and the irradiation surface of the irradiator, an airflow generator configured to generate an airflow along the irradiation surface between the irradiation surface of the irradiator and the channel plate, and a suction device configured to suck and discharge the airflow in a direction from the irradiation surface of the irradiator toward the conveyor.

Abstract: Provided is an orally disintegrating tablet evaluating method includes: measuring the mass of tablet; placing the tablet on a preparation placement surface of a test solution supply unit; measuring a water absorption time for a test solution to penetrate from one end of the tablet in contact with the surface to the other end of the tablet; measuring the mass of the tablet for which the time for the solution to penetrate has been measured; and calculating the water absorption rate of the tablet by the following formula (1); wherein the tablet is evaluated based on a water absorption rate of the tablet of 0.004 g/sec: water absorption rate of tablet=(mass of tablet after measurement of time for solution to penetrate?mass of tablet before measurement of time for solution to penetrate)/(time for solution to penetrate from one end to other end)??(1).

Abstract: To provide a mirabegron-containing tablet that maintains the amorphous form of mirabegron even after long-term storage. Also, to provide a mirabegron-containing pharmaceutical preparation that can maintain the purity of mirabegron while preventing the generation of related substances at the time of storage, a method for producing a mirabegron-containing pharmaceutical preparation, and a method for producing a mirabegron-containing granulated product. According to an embodiment of the present invention, there is provided a mirabegron-containing pharmaceutical preparation containing mirabegron, hypromellose, and polyvinylpyrrolidone. The mirabegron-containing pharmaceutical preparation may contain a spray-dried granulated product containing the mirabegron, the hypromellose, and the polyvinylpyrrolidone.

Abstract: An image forming apparatus includes an applicator and an irradiator. The applicator is configured to apply a liquid composition containing water or an organic solvent onto a recording medium. The irradiator is configured to irradiate the recording medium with light having a peak wavelength of 300 nm to 450 nm.

Abstract: A coating apparatus is connectable to both an image forming apparatus and a sheet feeder. The coating apparatus includes a coater, a carry-in entrance, and an ejector. The coater coats a recording medium with a treatment liquid. The carry-in entrance is on one of two exterior wall surfaces facing each other. The recording medium is conveyed from the sheet feeder through the carry-in entrance. The ejector is on another of the two exterior wall surfaces. The ejector ejects the recording medium to the image forming apparatus. A position of the carry-in entrance on the one of the exterior wall surfaces matches a position of the ejector on said another of the exterior wall surfaces.

Abstract: A cooling device includes a cooling member to absorb heat from a conveyed sheet and a plurality of cooling units to cool the cooling member. Each of the cooling units includes a coolant channel through which a coolant flows and a liquid-cooling device configured to cool the coolant that flows in the coolant channel. The coolant channels are disposed on or inside the cooling member and arranged side by side in a sheet conveyance direction. The coolant channels includes a downstream coolant channel being downstream from at least one of the plurality of coolant channels in the sheet conveyance direction, and an upstream coolant channel being upstream from the downstream coolant channel in the sheet conveyance direction. One of the liquid-cooling devices coupled to the downstream coolant channel has a cooling capacity higher than a cooling capacity of another of the liquid-cooling devices coupled to the upstream coolant channel.

Abstract: A coating apparatus is connectable to both an image forming apparatus and a sheet feeder. The coating apparatus includes a coater, a carry-in entrance, and an ejector. The coater coats a recording medium with a treatment liquid. The carry-in entrance is on one of two exterior wall surfaces facing each other. The recording medium is conveyed from the sheet feeder through the carry-in entrance. The ejector is on another of the two exterior wall surfaces. The ejector ejects the recording medium to the image forming apparatus. A position of the carry-in entrance on the one of the exterior wall surfaces matches a position of the ejector on said another of the exterior wall surfaces.

Abstract: An application apparatus includes a first roller configured to apply a treatment liquid to a recording medium conveyed; and a second roller disposed in contact with the first roller and forming, with the first roller, a conveyance nip in which the recording medium is nipped. The application apparatus further includes a third roller disposed in contact with the first roller at a position different from the conveyance nip, and a fourth roller disposed in contact with the second roller at a position different from the conveyance nip. The third roller has a rigidity higher than a rigidity of the first roller, and the fourth roller has rigidity higher than a rigidity of the second roller.

Abstract: A separation member that is used to separate a conveyance object from two rotation members, the conveyance object having been sent out from a nip that is formed by the two rotation members that are in contact with one another, the separation member includes a wavy part directed toward the nip and inclined from a normal to a center line of the two rotation members at a predetermined angle. The wavy part covers a contact zone where the conveyance object can come into contact with the separation member along a conveyance direction and along a width direction of the conveyance object, and the wavy part has a plurality of depressions parallel to each other and extending in a direction inclined from the conveyance direction and inclined from the width direction, at least two of the depressions overlapping along the conveyance direction.

Abstract: A coating apparatus is connectable to both an image forming apparatus and a sheet feeder. The coating apparatus includes a coater, a carry-in entrance, and an ejector. The coater coats a recording medium with a treatment liquid. The carry-in entrance is on one of two exterior wall surfaces facing each other. The recording medium is conveyed from the sheet feeder through the carry-in entrance. The ejector is on another of the two exterior wall surfaces. The ejector ejects the recording medium to the image forming apparatus. A position of the carry-in entrance on the one of the exterior wall surfaces matches a position of the ejector on said another of the exterior wall surfaces.

Abstract: Provided is a novel additive for an orally disintegrating tablet providing quick disintegrability and tablet hardness to the orally disintegrating tablet, and a producing method therefor. According to an embodiment of the present invention, there is provided an additive for an orally disintegrating tablet characterized by including D-mannitol, low-substituted hydroxypropyl cellulose (however, excluding the low-substituted hydroxypropyl cellulose having a mean particle size of 20 ?m or less and a substitution degree of hydroxypropoxy groups of 11%, a mean particle size of 45 ?m or less and a substitution degree of hydroxypropoxy groups of 14%, and a mean particle size of 45 ?m or less and a substitution degree of hydroxypropoxy groups of 11% and a 90% cumulated particle size of 100 ?m or less), crospovidone, and microcrystalline cellulose, wherein the low-substituted hydroxypropyl cellulose and the crospovidone are included in a ratio of 5:4.

Abstract: Provided is a novel additive for an orally disintegrating tablet which imparts a rapid disintegration property and a tablet hardness to the orally disintegrating tablet and a method for producing the same. An additive for an orally disintegrating tablet according to one embodiment of the present invention includes a D-mannitol, a low-substituted hydroxypropyl cellulose (excluding those having a mean particle size of 20 ?m or less and a substitution degree of the hydroxypropoxy groups of 11%, having a mean particle size of 45 ?m or less and a substitution degree of the hydroxypropoxy groups of 14% and having a mean particle size of 45 ?m or less and a substitution degree of the hydroxypropoxy groups of 11% together with a 90% cumulated particle size of 100 ?m or less), a crospovidone and a crystalline cellulose.

Abstract: Provided is an orally disintegrating tablet evaluating method includes: measuring the mass of tablet; placing the tablet on a preparation placement surface of a test solution supply unit; measuring a water absorption time for a test solution to penetrate from one end of the tablet in contact with the surface to the other end of the tablet; measuring the mass of the tablet for which the time for the solution to penetrate has been measured; and calculating the water absorption rate of the tablet by the following formula (1); wherein the tablet is evaluated based on a water absorption rate of the tablet of 0.004 g/sec: water absorption rate of tablet=(mass of tablet after measurement of time for solution to penetrate?mass of tablet before measurement of time for solution to penetrate)/(time for solution to penetrate from one end to other end) (1).

Abstract: A separation member that is used to separate a conveyance object from two rotation members, the conveyance object having been sent out from a nip that is formed by the two rotation members that are in contact with one another, the separation member includes a wavy part directed toward the nip and inclined from a normal to a center line of the two rotation members at a predetermined angle. The wavy part covers a contact zone where the conveyance object can come into contact with the separation member along a conveyance direction and along a width direction of the conveyance object, and the wavy part has a plurality of depressions parallel to each other and extending in a direction inclined from the conveyance direction and inclined from the width direction, at least two of the depressions overlapping along the conveyance direction.

Abstract: To provide a mirabegron-containing tablet that maintains the amorphous form of mirabegron even after long-term storage. Also, to provide a mirabegron-containing pharmaceutical preparation that can maintain the purity of mirabegron while preventing the generation of related substances at the time of storage, a method for producing a mirabegron-containing pharmaceutical preparation, and a method for producing a mirabegron-containing granulated product. According to an embodiment of the present invention, there is provided a mirabegron-containing pharmaceutical preparation containing mirabegron, hypromellose, and polyvinylpyrrolidone. The mirabegron-containing pharmaceutical preparation may contain a spray-dried granulated product containing the mirabegron, the hypromellose, and the polyvinylpyrrolidone.

Abstract: A fixing device includes a fixing belt that is endless and rotatable in a rotation direction and a nip former stretching the fixing belt and including an elastic layer as a surface layer. A pressure rotator presses against the nip former via the fixing belt to form a fixing nip between the fixing belt and the pressure rotator, through which a recording medium is conveyed. A presser is disposed downstream from an exit of the fixing nip in a recording medium conveyance direction. The presser brings the fixing belt into contact with the pressure rotator.