Abstract: The present invention relates to a method for improving symptom of mood disorder or its related disorder comprising a step of allowing Gm1 protein and the like to be excessively present in a brain of a mammal, and a non-human mammal, to which the method has been applied, and the like.

Abstract: A novel protein (Gm1) includes an amino acid sequence part having a high homology with a domain having a high homology with a GTP binding site and a GTPase site conserved among G protein ? subunits and a trimer forming domain conserved among G protein ? subunits. The Gm1 protein is involved in signal transduction via a G protein-coupled receptor (GPCR) stimulation. The Gm1 protein is expressed intensively in human brain, thymus, testes, spleen, small intestine, uterus and heart.

Abstract: A novel protein (Gm1) includes an amino acid sequence part having a high homology with a domain having a high homology with a GTP binding site and a GTPase site conserved among G protein ? subunits and a trimer forming domain conserved among G protein ? subunits. The Gm1 protein is involved in signal transduction via a G protein-coupled receptor (GPCR) stimulation. The Gm1 protein is expressed intensively in human brain, thymus, testes, spleen, small intestine, uterus and heart. A method for screening for a substance capable of regulating a cellular signal transduction employs a polynucleotide encoding the Gm1 protein.

Abstract: The present invention provides a common marmoset-derived hypoxanthine-guanine phosphoribosyltransferase gene and use thereof.

Abstract: Raffinose synthase genes coding for proteins capable of producing raffinose by combining a D-galactosyl group through an ?(1?6) bond with a hydroxyl group attached to the carbon atom at position 6 of a D-glucose residue in a sucrose molecule were isolated from various plants. These raffinose synthase genes are useful to change the content of raffinose family oligosaccharides in plants.

Abstract: The present invention relates to a method for improving symptom of mood disorder or its related disorder comprising a step of allowing Gm1 protein and the like to be excessively present in a brain of a mammal, and a non-human mammal, to which the method has been applied, and the like.

Abstract: Raffinose synthase genes coding for proteins capable of producing raffinose by combining a D-galactosyl group through an ?(1?6) bond with a hydroxyl group attached to the carbon atom at position 6 of a D-glucose residue in a sucrose molecule were isolated from various plants. These raffinose synthase genes are useful to change the content of raffinose family oligosaccharides in plants.

Abstract: The present invention relates to a method for improving symptom of mood disorder or its related disorder comprising a step of allowing activated-type Gm1 protein and the like to be excessively present in a brain of a mammal, and a non-human mammal, to which the method has been applied, and the like.

Abstract: The present invention provides a common marmoset-derived glyceraldehyde-3-phosphate dehydrogenase gene and use thereof.

Abstract: A novel protein (Gm1) includes an amino acid sequence part having a high homology with a domain having a high homology with a GTP binding site and a GTPase site conserved among G protein ? subunits and a trimer forming domain conserved among G protein ? subunits. The Gm1 protein is involved in signal transduction via a G protein-coupled receptor (GPCR) stimulation. The Gm1 protein is expressed intensively in human brain, thymus, testes, spleen, small intestine, uterus and heart. A method for screening for a substance capable of regulating a cellular signal transduction employs a polynucleotide encoding the Gm1 protein.

Abstract: We identified a novel protein (Gm1) comprising an amino acid sequence part having a high homology with a domain having a high homology with a GTP binding site and a GTPase site conserved among G protein ? subunits and a trimer forming domain conserved among G protein ? subunits. The Gm1 is involved in an signal transduction via a G protein-coupled receptor (GPCR) stimulation. Accordingly, this protein is considered to be a novel G protein. The Gm1 is expressed intensively in human brain, thymus, testes, spleen, small intestine, uterus and heart. We also established a method for screening for a substance capable of regulating a cellular signal transduction employing a polynucleotide encoding the Gm1.

Abstract: The present invention relates to a knockout non-human animal whose genome comprises a disruption in at least one allele of the PHF3 gene, useful in developing drugs for diseases with the onset of atopic dermatitis or the like; a totipotent cell such as an ES cell which is essential to production of the above non-human animal; use thereof; and so on.

Abstract: The present invention relates to a polynucleotide comprising a nucleotide sequence of a promoter region of a gene encoding ? subunit Gm1 of trimeric G-protein, more specifically, said polynucleotide, wherein the nucleotide sequence of a promoter region is, for example, any of the following nucleotide sequences (1) and (2): (1) the nucleotide sequence of SEQ ID NO: 1, and (2) the nucleotide sequence of the nucleotide numbers 603 to 3871 in the nucleotide sequence of SEQ ID NO: 1 and the like.

Abstract: Promoters capable of efficiently expressing a gene of interest in plants include (1) either a DNA containing SEQ ID No:1 or SEQ ID No:7, or a biological functional equivalent DNA containing SEQ ID No:1 or SEQ ID No:7 that have modifications in their respective nucleotide sequence provided that each retains more than 90% identity to the nucleotide sequence of any region containing at least 250 bp within SEQ ID No:1 or SEQ ID No:7, respectively. Terminators capable of efficiently expressing a gene of interest in plants include either a DNA containing SEQ ID No:2, or a biological functional equivalent DNA containing a SEQ ID No:2 that has a modified nucleotide sequence provided that it retains more than 90% identity to the nucleotide sequence of any region containing at least 250 bp within SEQ ID No:2.

Abstract: The present invention provides a common marmoset-derived beta-actin gene and use thereof.

Abstract: The present invention provides a common marmoset-derived hypoxanthine-guanine phosphoribosyltransferase gene and use thereof.

Abstract: The present invention provides a common marmoset-derived glyceraldehyde-3-phosphate dehydrogenase gene and use thereof.

Abstract: The present invention provides a common marmoset-derived beta-actin gene and use thereof.

Abstract: We identified a novel protein (Gm1) comprising an amino acid sequence part having a high homology with a domain having a high homology with a GTP binding site and a GTPase site conserved among G protein ? subunits and a trimer forming domain conserved among G protein ? subunits. The Gm1 is involved in an signal transduction via a G protein-coupled receptor (GPCR) stimulation. Accordingly, this protein is considered to be a novel G protein. The Gm1 is expressed intensively in human brain, thymus, testes, spleen, small intestine, uterus and heart. We also established a method for screening for a substance capable of regulating a cellular signal transduction employing a polynucleotide encoding the Gm1.

Abstract: The present invention provides a promoter including the following DNA (a) or (b): (a) the DNA consisting of the nucleotide sequence of nucleotide numbers 1743 to 2301 in the nucleotide sequence represented by SEQ ID: No. 1; or, (b) the DNA which can be hybridized with said DNA (a) in a stringent condition and having a promoter function in a plant cell, and the like.