Abstract: A human antibody which comprises a complementarity determining region of an H chain consisting of the amino acid sequence as shown in SEQ ID NOs: 1 to 3 and a complementarity determining region of an L chain consisting of the amino acid sequence as shown in SEQ ID NOs: 4 to 6. The human antibody of the present invention has the activity to specifically bind to transthyretin (TTR) with structural change and the activity to inhibit fibrillization of TTR and is a human antibody suitable for application to human body.

Abstract: A human antibody which comprises a complementarity determining region of an H chain consisting of the amino acid sequence as shown in SEQ ID NOs: 1 to 3 and a complementarity determining region of an L chain consisting of the amino acid sequence as shown in SEQ ID NOs: 4 to 6. The human antibody of the present invention has the activity to specifically bind to transthyretin (TTR) with structural change and the activity to inhibit fibrillization of TTR and is a human antibody suitable for application to human body.

Abstract: A humanized antibody which comprises a complementarity determining region of an H chain consisting of the amino acid sequence as shown in SEQ ID NOs: 1 to 3 and a complementarity determining region of an L chain consisting of the amino acid sequence as shown in SEQ ID NOs: 4 to 6. The humanized antibody of the present invention has the activity to specifically bind to transthyretin (TTR) with structural change and the activity to inhibit fibrillization of TTR and is a humanized antibody suitable for application to human body.

Abstract: A human antibody which comprises a complementarity determining region of an H chain consisting of the amino acid sequence as shown in SEQ ID NOs: 1 to 3 and a complementarity determining region of an L chain consisting of the amino acid sequence as shown in SEQ ID NOs: 4 to 6. The human antibody of the present invention has the activity to specifically bind to transthyretin (TTR) with structural change and the activity to inhibit fibrillization of TTR and is a human antibody suitable for application to human body.

Abstract: The present invention relates to a human anti-human IL-18 antibody which reacts with human interleukin-18 (human IL-18) and does not react with a K53A variant of human IL-18.

Abstract: The present invention relates to a human anti-human IL-18 antibody which reacts with human interleukin-18 (human IL-18) and does not react with a K53A variant of human IL-18.

Abstract: Consistency between a requirement for communication with respect to software in a system and a requirement for a network is maintained, without re-designing a network by the user. A requirement conversion unit (110) of a system design support device (100) generates a requirement for communication between computers based on a requirement for communication between software components included in a system, and based on identifiers of the computers in which the software components are deployed. The requirement conversion unit (110) generates a requirement for a network for connecting between the computers based on the requirement for communication between the computers.

Abstract: An objective of the present invention is to construct a system in which a plurality of software components having dependencies are deployed dispersedly on a plurality of processing devices. The information system includes a deployment device (100) and a plurality of processing devices (200). A scheduler (210) of the processing device (200) determine whether there is a deployment task satisfying an execution condition in task information (231) on the basis of a termination event of a deployment task. When there is a deployment task satisfying the execution condition, the scheduler (210) executes the deployment task and transmits a termination event of the deployment task to the deployment device (100). An event processing unit (130) of the deployment device (100) transmits the termination event of the deployment task to a notification destination processing device (200) referring to event information (141).

Abstract: A humanized antibody which comprises a complementarity determining region of an H chain consisting of the amino acid sequence as shown in SEQ ID NOs: 1 to 3 and a complementarity determining region of an L chain consisting of the amino acid sequence as shown in SEQ ID NOs: 4 to 6. The humanized antibody of the present invention has the activity to specifically bind to transthyretin (TTR) with structural change and the activity to inhibit fibrillization of TTR and is a humanized antibody suitable for application to human body.

Abstract: A human antibody which comprises a complementarity determining region of an H chain consisting of the amino acid sequence as shown in SEQ ID NOs: 1 to 3 and a complementarity determining region of an L chain consisting of the amino acid sequence as shown in SEQ ID NOs: 4 to 6. The human antibody of the present invention has the activity to specifically bind to transthyretin (TTR) with structural change and the activity to inhibit fibrillization of TTR and is a human antibody suitable for application to human body.

Abstract: Consistency between a requirement for communication with respect to software in a system and a requirement for a network is maintained, without re-designing a network by the user. A requirement conversion unit (110) of a system design support device (100) generates a requirement for communication between computers based on a requirement for communication between software components included in a system, and based on identifiers of the computers in which the software components are deployed. The requirement conversion unit (110) generates a requirement for a network for connecting between the computers based on the requirement for communication between the computers.

Abstract: Internal processes of specified components are connected to each other when an application is executed regardless of interface definition between the components and a new process is executed. A program processing apparatus (100) includes an aspect application unit (102) which generates a routing unit (201) and a connector unit (301) and applies the routing unit (201) and the connector unit (301), respectively to a component (200) and a component (300) which are included in an activated program, and a configuration management unit (101) which causes the routing unit (201) applied to the component (200) and the connector unit (301) applied to the component (300) to establish a communication connection with each other and causes the component (300) to send a process result of an process instruction in the component (300) to the component (200) through the established communication connection.

Abstract: An objective of the present invention is to construct a system in which a plurality of software components having dependencies are deployed dispersedly on a plurality of processing devices. The information system includes a deployment device (100) and a plurality of processing devices (200). A scheduler (210) of the processing device (200) determine whether there is a deployment task satisfying an execution condition in task information (231) on the basis of a termination event of a deployment task. When there is a deployment task satisfying the execution condition, the scheduler (210) executes the deployment task and transmits a termination event of the deployment task to the deployment device (100). An event processing unit (130) of the deployment device (100) transmits the termination event of the deployment task to a notification destination processing device (200) referring to event information (141).

Abstract: A program setting device to allow setting items of a program to be flexibly defined in accordance with a level of skill of a user is provided. A program setting device (100) includes a concretization logic execution unit (121) and a set value determination unit (120). The concretization logic execution unit (121) executes a concretization logic (311) for calculating a concrete setting item (302) which is a setting item specific to each of a plurality of implementations of a program from an abstract setting item (202) which is a setting item common to the plurality of implementations of the program.

Abstract: An enhanced disintegrin-like domain, and metalloprotease, with an isolated human thrombospondin type 1 motif, member 13 (ADAMTS-13) that includes substitutions at one or more positions in the isolated human ADAMTS-13.

Abstract: There are provided: a test executing section which generates a plurality of logs when executing a coverage test for an application based on an inputted parameter; and a result processing section which generates a point candidate report based on the plurality of logs. The plurality of logs respectively indicate a call stack of a method designating the parameter as an argument among a plurality of methods called during execution of the coverage test. The call stack indicates a location on the application, in which a call of the method is defined. The point candidate report indicates a candidate for a point in the application, for which a modification is necessary when a dispatch of process is executed based on the parameter.

Abstract: An enhanced disintegrin-like domain, and metalloprotease, with an isolated human thrombospondin type 1 motif, member 13 (ADAMTS-13) that includes substitutions at one or more positions in the isolated human ADAMTS-13.

Abstract: A construction procedure of a system which is constructed by performing operations of plural types with respect to each of plural program modules is generated. A system-construction-procedure generating device (100) includes a dependency relationship storing unit (111), an operating procedure storing unit (112), and an operating procedure generating unit (102). The dependency relationship storing unit (111) stores dependency relationship information (121) indicating a dependency relationship (123) for each of one or more pairs of operations among a plurality of operations each expressed with a combination of one of a plurality of program modules and one of a plurality of operation types, the plurality of operations being required for system construction. The operating procedure storing unit (112) stores a procedure sequence (122) indicating a sequence for performing each of the plurality of operations.

Abstract: An enhanced disintegrin-like domain, and metalloprotease, with an isolated human thrombospondin type 1 motif, member 13 (ADAMTS-13) that includes substitutions at one or more positions in the isolated human ADAMTS-13.

Abstract: An enhanced disintegrin-like domain, and metalloprotease, with an isolated human thrombospondin type 1 motif, member 13 (ADAMTS-13) that includes substitutions at one or more positions in the isolated human ADAMTS-13.