Abstract: The present disclosure relates to methods and assays for quantifying brain-derived exosomes in biological samples from subjects before, during, and after surgery. The disclosure also provides methods and compositions for measuring and/or prognosing brain damage during surgery. The compositions and methods of the disclosure are also useful for preventing and/or treating brain damage in subjects undergoing surgery and predicting postoperative cognitive dysfunction (POCD) and/or predicting postoperative delirium (POD).

Abstract: An autonomic nervous activity monitor capable of predicting occurrence of abnormal reaction depending on autonomic nervous activity and used for medical practice and the like is provided. A blood component collecting apparatus 100 carries out frequency analysis to a pattern of heartbeat which is acquired by an ECG 300 from a donor, and calculates a high frequency component value [msec2] defined as an indicator for parasympathetic activity and a ratio value of a low frequency component to the high frequency component defined as an indicator for sympathetic activity to detect a change in these values on a time-series base. When a judgment circuit 204 predicts that abnormal reaction may occur to a donor after blood collection operation is started, a controller 200 controls a pump 9 to decrease a blood drawing or blood returning speed, or, to stop blood drawing or blood returning operation.

Abstract: An autonomic nervous activity monitor capable of predicting occurrence of abnormal reaction depending on autonomic nervous activity and used for medical practice and the like is provided. A blood component collecting apparatus 100 carries out frequency analysis to a pattern of heartbeat which is acquired by an ECG 300 from a donor, and calculates a high frequency component value [msec2] defined as an indicator for parasympathetic activity and a ratio value of a low frequency component to the high frequency component defined as an indicator for sympathetic activity to detect a change in these values on a time-series base. When a judgment circuit 204 predicts that abnormal reaction may occur to a donor after blood collection operation is started, a controller 200 controls a pump 9 to decrease a blood drawing or blood returning speed, or, to stop blood drawing or blood returning operation.

Abstract: An autonomic nervous activity monitor capable of predicting occurrence of abnormal reaction depending on autonomic nervous activity and used for medical practice and the like is provided. A blood component collecting apparatus 100 carries out frequency analysis to a pattern of heartbeat which is acquired by an ECG 300 from a donor, and calculates a high frequency component value [msec2] defined as an indicator for parasympathetic activity and a ratio value of a low frequency component to the high frequency component defined as an indicator for sympathetic activity to detect a change in these values on a time-series base. When a judgment circuit 204 predicts that abnormal reaction may occur to a donor after blood collection operation is started, a controller 200 controls a pump 9 to decrease a blood drawing or blood returning speed, or, to stop blood drawing or blood returning operation.

Abstract: A Schmitt trigger circuit which eliminates malfunctions due to high frequency noise and is operable for signals in the direct current region, includes a resistor provided between an input terminal and an input node of MOS inverters, and a capacitor provided in feedback loop. The resistor and the capacitor act as a low pass filter. The capacitor maintains the Schmitt operation by its charging operation, despite the inclusion of noise in the input signal.