Abstract: A fiber web containing hardwood pulp is impregnated with a chemical solution that contains a moisturizing component such as glycerin, moisture, an oily component such as hydrocarbons, and a vegetable powder such as corn starch. The vegetable powder enters between pulp fibers of the fiber web in which hydrogen bonds are relaxed by the moisturizing component and the oily component, thereby spontaneously raising some of the pulp fibers in a surface of the fiber web. Accordingly, a fiber web product that is excellent in texture characteristics such as a smooth raised feeling, softness, and moistness, generates less dust such as powder or pulp fibers, and has sufficient strength, and a manufacturing method of the same are provided.

Abstract: An air purification system is provided that includes a housing and one or more anti-viral units which promote hydroxyl generation in air streams. The housing is configured to allow airflow to travel therethrough and anti-viral unit(s) include a substrate material, and an anti-viral agent material supported on the substrate material. The anti-viral agent material can be a mineral powder containing a metal oxide and a metal hydroxide suitable for hydroxyl generation. The system may also contain at least one light source, and the one or more anti-viral units can also contain activated charcoal and/or titanium dioxide. The air purification system is used in a structure. The system emits hydroxyls into the structure to neutralize viruses, odors, bacteria, and/or other pathogens in the structure.

Abstract: A fiber web containing hardwood pulp is impregnated with a chemical solution that contains a moisturizing component such as glycerin, moisture, an oily component such as hydrocarbons, and a vegetable powder such as corn starch. The vegetable powder enters between pulp fibers of the fiber web in which hydrogen bonds are relaxed by the moisturizing component and the oily component, thereby spontaneously raising some of the pulp fibers in a surface of the fiber web. Accordingly, a fiber web product that is excellent in texture characteristics such as a smooth raised feeling, softness, and moistness, generates less dust such as powder or pulp fibers, and has sufficient strength, and a manufacturing method of the same are provided.

Abstract: An objective of the present disclosure is to provide: anticancer agents having an immune cell-activating effect, a cytotoxic activity, or an antitumor activity, but having a low effect on non-tumor tissues such as normal tissues and having few side effects; combination therapies using those anticancer agents and other anticancer agents; and pharmaceutical combinations for use in those combination therapies. Anticancer agents expected to be applied to various types of cancers, which have an immune cell-activating effect, a cytotoxic activity, or an antitumor activity while having a low effect on non-tumor tissues such as normal tissues and having few side effects by using as an active ingredient an anti-CD137 antigen-binding molecule of the present disclosure, the binding activity of which to CD137 changes depending on various substances (for example, low molecular weight compounds) in target tissues, are provided.

Abstract: The present invention provides methods for treating or preventing cancer by administering an anticancer agent and an antigen-binding molecule comprising a domain that binds to a molecule expressed on the surface of a cell having an immune response-suppressing function and a T cell receptor complex-binding domain. The present invention also provides pharmaceutical compositions for treating or preventing cancer, each comprising a combination of the anticancer agent and the antigen-binding molecule.

Abstract: It was discovered that the use of an antigen-binding molecule having a cancer-specific antigen-binding domain, and a TNF superfamily-binding domain or a TNF receptor superfamily-binding domain enables agonist activity against a factor belonging to the TNF superfamily or the TNF receptor superfamily to be exhibited only in the presence of cancer-specific antigen-expressing cells, thus leading to activation of immune cells and thereby maintain anti-tumor activity while avoiding side effects such as hepatotoxicity. It was also discovered that concomitant use of the antigen-binding molecule with an antigen-binding molecule having a cancer-specific antigen-binding domain and a T cell receptor complex-binding domain can avoid side effects while increasing the anti-tumor activity.

Abstract: It was discovered that the use of an antigen-binding molecule having a cancer-specific antigen-binding domain, and a TNF superfamily-binding domain or a TNF receptor superfamily-binding domain enables agonist activity against a factor belonging to the TNF superfamily or the TNF receptor superfamily to be exhibited only in the presence of cancer-specific antigen-expressing cells, thus leading to activation of immune cells and thereby maintain anti-tumor activity while avoiding side effects such as hepatotoxicity. It was also discovered that concomitant use of the antigen-binding molecule with an antigen-binding molecule having a cancer-specific antigen-binding domain and a T cell receptor complex-binding domain can avoid side effects while increasing the anti-tumor activity.

Abstract: It was discovered that antigen-binding molecules comprising (1) a domain that binds to a molecule expressed on the surface of cells having immune response-suppressing functions and (2) a T cell receptor complex-binding domain, crosslink T cells with the cells having immune response-suppressing functions and induce damage to the cells having immune response-suppressing functions to thereby exhibit more superior antitumor effects than conventional antigen-binding molecules. It was also discovered that combined use of the antigen-binding molecules and other anticancer agents further increases the antitumor effects.

Abstract: The present invention provides a compact automatic fire extinguishing equipment that can be installed near an object of fire extinguishing for which there is limited space therearound for a long term in a state of maintenance-free and that can extinguish a fire immediately on the occasion of a fire. The fire extinguishing equipment consists of a fire extinguishing agent 14 and a sealed container 12 filled with the fire extinguishing agent 14. And the fire extinguishing agent 14 is comprised with a compound that is liquid at 25 degrees Celsius (room temperature) at least and that has a boiling point of at least 75 degrees Celsius or less, having fire extinguishing effect. The container 12 is formed with lamination of gas barrier layer 16 and the thermoplastic resin layer 20, and the gas barrier layer 16 consists of ethylene-vinyl-alcohol copolymer resin (ethylene vinyl alcohol copolymer: EVOH).

Abstract: The present invention is based on the finding that combined use of a multispecific antibody comprising: (1) a cancer-specific antigen-binding domain, (2) a CD3-binding domain, and (3) a domain comprising an Fc region having decreased Fc? receptor-binding activity with a tumor necrosis factor (TNF) receptor superfamily agonist antibody can reduce side effects such as liver injury observed when the agonist antibody is prescribed alone, and achieve effective therapeutic effects.

Abstract: The present invention provides an automatic fire extinguishing device that can detect a fire at the temperature lower than 120 degrees Celsius and that can be installed for a long term in a state of maintenance-free. The fire extinguishing device consists of a pressure resistant container filled with the extinguishant and the pressurization agent, the container valve attached to the opening of the pressure resistant container, the fire detection tube connected to the container valve. And the fire detection tube is formed with the lamination of the tubular base resin layer and the gas barrier layer, the base resin layer is made of the thermoplastic resin and the gas barrier layer is made of ethylene vinyl alcohol copolymer resin (EVOH resin).

Abstract: It was discovered that the use of an antigen-binding molecule having a cancer-specific antigen-binding domain, and a TNF superfamily-binding domain or a TNF receptor superfamily-binding domain enables agonist activity against a factor belonging to the TNF superfamily or the TNF receptor superfamily to be exhibited only in the presence of cancer-specific antigen-expressing cells, thus leading to activation of immune cells and thereby maintain anti-tumor activity while avoiding side effects such as hepatotoxicity. It was also discovered that concomitant use of the antigen-binding molecule with an antigen-binding molecule having a cancer-specific antigen-binding domain and a T cell receptor complex-binding domain can avoid side effects while increasing the anti-tumor activity.

Abstract: The present invention provides a compact automatic fire extinguishing equipment that can be installed near an object of fire extinguishing for which there is limited space therearound for a long term in a state of maintenance-free and that can extinguish a fire immediately on the occasion of a fire. The fire extinguishing equipment consists of a fire extinguishing agent 14 and a sealed container 12 filled with the fire extinguishing agent 14. And the fire extinguishing agent 14 is comprised with a compound that is liquid at 25 degrees Celsius (room temperature) at least and that has a boiling point of at least 75 degrees Celsius or less, having fire extinguishing effect. The container 12 is formed with lamination of gas barrier layer 16 and the thermoplastic resin layer 20, and the gas barrier layer 16 consists of ethylene-vinyl-alcohol copolymer resin (ethylene vinyl alcohol copolymer: EVOH).

Abstract: The present invention provides an automatic fire extinguishing device that can detect a fire at the temperature lower than 120 degrees Celsius and that can be installed for a long term in a state of maintenance-free. The fire extinguishing device consists of a pressure resistant container filled with the extinguishant and the pressurization agent, the container valve attached to the opening of the pressure resistant container, the fire detection tube connected to the container valve. And the fire detection tube is formed with the lamination of the tubular base resin layer and the gas barrier layer, the base resin layer is made of the thermoplastic resin and the gas barrier layer is made of ethylene vinyl alcohol copolymer resin (EVOH resin).

Abstract: An imidazole derivative represented by formula (I): wherein Q is: A is hydrogen, halogen, or a substituted or unsubstituted C1-4 alkyl group; E is independently selected from a C1-6 alkyl group; R2 and R3 are independently selected from C1-6 alkyls; X1 and X2 are independently selected from O and S; Y is selected from a substituted or unsubstituted arylene group and a substituted or unsubstituted divalent 5- or 6-membered monocyclic or 8- to 10-membered condensed heterocyclic group; Z is —CON(—Ra)—, —CO—, —OOO—, —NRa—C(?NH)NRb—, —NRa—C(?N—CN)NRb—, —N(—Ra)COO—, —C(?NH)—, —SO2—, —SO2N(—Ra)—, —SO2NR1—, —N(—Ra)CO—, —N(—Ra)CON(—Rb)—, —N(COR1)CO—, —N(—Ra)SO2—, —N(SO2R1)SO2—, —N(—Ra)— or —N(—Ra)SO2N(—Rb)—; R1 is independently a hydrogen atom, a hydroxyl group, or substituted or unsubstituted group selected from C1-6 alkyl group, heterocyclic group, aryl group, C3-8 cycloalkyl group and C3-8 cycloalkenyl group; or salt or prodrug thereof.

Abstract: According to the present invention, a compound represented by formula (I): wherein Q is: A is a hydrogen atom, a halogen atom, —ORa or a C1-4 alkyl group which may be substituted by one or more halogen atoms; E is independently selected from a C1-6 alkyl group; m is selected from integers from 0 to 3; R2 and R3 are independently selected from a C1-6 alkyl group; X1 and X2 are independently selected from O and S; Y is selected from an arylene group and a divalent 5- or 6-membered monocyclic or 8- to 10-membered condensed heterocyclic group, wherein the arylene group and the heterocyclic group may be substituted by 1 to 3 substituents independently selected from E1; E1 is independently selected from a hydroxyl group, a halogen atom, a C1-4 alkyl group, a cyano group, a C1-4 alkoky group, a carbamoyl group, a C1-4 alkylcarbamoyl group, a di(C1-4 alkyl)carbamoyl group, an amino group, a C1-4 alkylamino group, a di(C1-4 alkylamino group, a sulfamoyl group, a C1-4 alkylsulfamoyl group and a di(C1-4 alkyl)su

Abstract: A plurality of pixel portions (12) are formed on a silicon substrate (11). A photoelectric converter portion (10) constituting each of the pixel portions (12) is electrically isolated by an element isolation portion (13) comprising an insulating film formed on the silicon substrate (11). The photoelectric converter portion (10) partitioned by the element isolation portion (13) is so formed that a crystal orientation of the sides in contact with the element isolation portion (13) corresponds to a <00-1> direction. This makes it possible to reduce dark current caused by stress in the vicinity of the interface of the element isolation portion (13) and maintain high sensitivity even if the pixel portions (12) are made smaller in size.

Abstract: An antenna apparatus includes a base member that has an antenna unit and a loop pattern. The loop pattern is wound in such a manner that a magnetic field of the loop pattern is generated along the same direction as that of the antenna unit. Additionally, the loop pattern is formed by a plurality of loops connected parallel to each other.

Abstract: An object of the present invention is to provide an embossed crepe paper which can clearly be formed into fine embossed shapes, and is excellent in the fluffy feel and therefore excellent in such as absorbency for fats. As a means of achieving this object, the method for manufacturing an embossed crepe paper, according to the present invention, is a method for manufacturing an embossed crepe paper comprising a step of embossing a raw crepe paper, wherein: a raw paper having a basis weight of 6 to 28 g/m2 is used as the raw crepe paper; and the embossing step includes the steps of: (a) supplying the raw crepe paper with water in an amount of 0.1 to 100 weight % based on the basis weight to thereby put the raw crepe paper in a wet condition; (b) embossing the wet-conditioned raw crepe paper; and (c) drying the embossed wet-conditioned raw crepe paper.

Abstract: An object of the present invention is to provide an embossed crepe paper which can clearly be formed into fine embossed shapes, and is excellent in the fluffy feel and therefore excellent in such as absorbency for fats. As a means of achieving this object, the method for manufacturing an embossed crepe paper, according to the present invention, is a method for manufacturing an embossed crepe paper comprising a step of embossing a raw crepe paper, wherein: a raw paper having a basis weight of 6 to 28 g/m2 is used as the raw crepe paper; and the embossing step includes the steps of: (a) supplying the raw crepe paper with water in an amount of 0.1 to 100 weight % based on the basis weight to thereby put the raw crepe paper in a wet condition; (b) embossing the wet-conditioned raw crepe paper; and (c) drying the embossed wet-conditioned raw crepe paper.