Abstract: An electric motor system includes a battery, an inverter, an electric motor, a zero-phase switching arm and a control unit. The inverter converts DC power output from the battery into three-phase AC power and outputs the three-phase AC power to the electric motor. A rotor of the electric motor rotates by the three-phase AC power output from the inverter. A neural point of the electric motor is connected to the zero-phase switching arm. A zero-phase current flowing through respective windings of the electric motor is adjusted by switching of the zero-phase switching arm. By this means, in the electric motor system, torque is generated at the rotor also using the zero-phase current as well as a three-phase AC current flowing through the respective windings.

Abstract: Disclosed is a substrate treating apparatus provided with a treating block. The treating block includes a wet transportation region adjoining a batch treatment region and a single-wafer transportation region. The wet transportation region contains a second posture turning mechanism provided on an extension line of a line of six batch process tanks and configured to turn a posture of substrates, on which immersion treatment is performed, from vertical to horizontal, a belt conveyor mechanism configured to receive the substrates in a horizontal posture one by one from the second posture turning mechanism and transport the substrates to the single-wafer transportation region, and a liquid supplying unit configured to supply a liquid to wet the substrates, transported by the belt conveyor mechanism, with the liquid.

Abstract: A sealing member that forms a combustion gas flow path of a gas turbine includes a first body portion having a cooling passage. The first body portion includes a first end portion forming one end portion in a circumferential direction, a second end portion forming the other end portion on an opposite side in the circumferential direction, and an intermediate portion formed between the first and second end portions. The cooling passage includes an intermediate portion cooling passage inclined at a first angle with respect to an axial direction, a first end portion cooling passage provided in the first end portion and inclined at a second angle with respect to the axial direction, and a second end portion cooling passage provided in the second end portion and inclined at a third angle with respect to the axial direction, and the second and third angles are smaller than the first angle.

Abstract: An objective of the present disclosure is to provide: anticancer agents having an immune cell-activating effect, a cytotoxic activity, or an antitumor activity, but having a low effect on non-tumor tissues such as normal tissues and having few side effects; combination therapies using those anticancer agents and other anticancer agents; and pharmaceutical combinations for use in those combination therapies. Anticancer agents expected to be applied to various types of cancers, which have an immune cell-activating effect, a cytotoxic activity, or an antitumor activity while having a low effect on non-tumor tissues such as normal tissues and having few side effects by using as an active ingredient an anti-CD137 antigen-binding molecule of the present disclosure, the binding activity of which to CD137 changes depending on various substances (for example, low molecular weight compounds) in target tissues, are provided.

Abstract: The present invention provides methods for treating or preventing cancer by administering an anticancer agent and an antigen-binding molecule comprising a domain that binds to a molecule expressed on the surface of a cell having an immune response-suppressing function and a T cell receptor complex-binding domain. The present invention also provides pharmaceutical compositions for treating or preventing cancer, each comprising a combination of the anticancer agent and the antigen-binding molecule.

Abstract: It was discovered that the use of an antigen-binding molecule having a cancer-specific antigen-binding domain, and a TNF superfamily-binding domain or a TNF receptor superfamily-binding domain enables agonist activity against a factor belonging to the TNF superfamily or the TNF receptor superfamily to be exhibited only in the presence of cancer-specific antigen-expressing cells, thus leading to activation of immune cells and thereby maintain anti-tumor activity while avoiding side effects such as hepatotoxicity. It was also discovered that concomitant use of the antigen-binding molecule with an antigen-binding molecule having a cancer-specific antigen-binding domain and a T cell receptor complex-binding domain can avoid side effects while increasing the anti-tumor activity.

Abstract: It was discovered that the use of an antigen-binding molecule having a cancer-specific antigen-binding domain, and a TNF superfamily-binding domain or a TNF receptor superfamily-binding domain enables agonist activity against a factor belonging to the TNF superfamily or the TNF receptor superfamily to be exhibited only in the presence of cancer-specific antigen-expressing cells, thus leading to activation of immune cells and thereby maintain anti-tumor activity while avoiding side effects such as hepatotoxicity. It was also discovered that concomitant use of the antigen-binding molecule with an antigen-binding molecule having a cancer-specific antigen-binding domain and a T cell receptor complex-binding domain can avoid side effects while increasing the anti-tumor activity.

Abstract: It was discovered that antigen-binding molecules comprising (1) a domain that binds to a molecule expressed on the surface of cells having immune response-suppressing functions and (2) a T cell receptor complex-binding domain, crosslink T cells with the cells having immune response-suppressing functions and induce damage to the cells having immune response-suppressing functions to thereby exhibit more superior antitumor effects than conventional antigen-binding molecules. It was also discovered that combined use of the antigen-binding molecules and other anticancer agents further increases the antitumor effects.

Abstract: The present invention provides a compact automatic fire extinguishing equipment that can be installed near an object of fire extinguishing for which there is limited space therearound for a long term in a state of maintenance-free and that can extinguish a fire immediately on the occasion of a fire. The fire extinguishing equipment consists of a fire extinguishing agent 14 and a sealed container 12 filled with the fire extinguishing agent 14. And the fire extinguishing agent 14 is comprised with a compound that is liquid at 25 degrees Celsius (room temperature) at least and that has a boiling point of at least 75 degrees Celsius or less, having fire extinguishing effect. The container 12 is formed with lamination of gas barrier layer 16 and the thermoplastic resin layer 20, and the gas barrier layer 16 consists of ethylene-vinyl-alcohol copolymer resin (ethylene vinyl alcohol copolymer: EVOH).

Abstract: The present invention is based on the finding that combined use of a multispecific antibody comprising: (1) a cancer-specific antigen-binding domain, (2) a CD3-binding domain, and (3) a domain comprising an Fc region having decreased Fc? receptor-binding activity with a tumor necrosis factor (TNF) receptor superfamily agonist antibody can reduce side effects such as liver injury observed when the agonist antibody is prescribed alone, and achieve effective therapeutic effects.

Abstract: The present invention provides an automatic fire extinguishing device that can detect a fire at the temperature lower than 120 degrees Celsius and that can be installed for a long term in a state of maintenance-free. The fire extinguishing device consists of a pressure resistant container filled with the extinguishant and the pressurization agent, the container valve attached to the opening of the pressure resistant container, the fire detection tube connected to the container valve. And the fire detection tube is formed with the lamination of the tubular base resin layer and the gas barrier layer, the base resin layer is made of the thermoplastic resin and the gas barrier layer is made of ethylene vinyl alcohol copolymer resin (EVOH resin).

Abstract: It was discovered that the use of an antigen-binding molecule having a cancer-specific antigen-binding domain, and a TNF superfamily-binding domain or a TNF receptor superfamily-binding domain enables agonist activity against a factor belonging to the TNF superfamily or the TNF receptor superfamily to be exhibited only in the presence of cancer-specific antigen-expressing cells, thus leading to activation of immune cells and thereby maintain anti-tumor activity while avoiding side effects such as hepatotoxicity. It was also discovered that concomitant use of the antigen-binding molecule with an antigen-binding molecule having a cancer-specific antigen-binding domain and a T cell receptor complex-binding domain can avoid side effects while increasing the anti-tumor activity.

Abstract: The present invention provides a compact automatic fire extinguishing equipment that can be installed near an object of fire extinguishing for which there is limited space therearound for a long term in a state of maintenance-free and that can extinguish a fire immediately on the occasion of a fire. The fire extinguishing equipment consists of a fire extinguishing agent 14 and a sealed container 12 filled with the fire extinguishing agent 14. And the fire extinguishing agent 14 is comprised with a compound that is liquid at 25 degrees Celsius (room temperature) at least and that has a boiling point of at least 75 degrees Celsius or less, having fire extinguishing effect. The container 12 is formed with lamination of gas barrier layer 16 and the thermoplastic resin layer 20, and the gas barrier layer 16 consists of ethylene-vinyl-alcohol copolymer resin (ethylene vinyl alcohol copolymer: EVOH).

Abstract: The present invention provides an automatic fire extinguishing device that can detect a fire at the temperature lower than 120 degrees Celsius and that can be installed for a long term in a state of maintenance-free. The fire extinguishing device consists of a pressure resistant container filled with the extinguishant and the pressurization agent, the container valve attached to the opening of the pressure resistant container, the fire detection tube connected to the container valve. And the fire detection tube is formed with the lamination of the tubular base resin layer and the gas barrier layer, the base resin layer is made of the thermoplastic resin and the gas barrier layer is made of ethylene vinyl alcohol copolymer resin (EVOH resin).

Abstract: An imidazole derivative represented by formula (I): wherein Q is: A is hydrogen, halogen, or a substituted or unsubstituted C1-4 alkyl group; E is independently selected from a C1-6 alkyl group; R2 and R3 are independently selected from C1-6 alkyls; X1 and X2 are independently selected from O and S; Y is selected from a substituted or unsubstituted arylene group and a substituted or unsubstituted divalent 5- or 6-membered monocyclic or 8- to 10-membered condensed heterocyclic group; Z is —CON(—Ra)—, —CO—, —OOO—, —NRa—C(?NH)NRb—, —NRa—C(?N—CN)NRb—, —N(—Ra)COO—, —C(?NH)—, —SO2—, —SO2N(—Ra)—, —SO2NR1—, —N(—Ra)CO—, —N(—Ra)CON(—Rb)—, —N(COR1)CO—, —N(—Ra)SO2—, —N(SO2R1)SO2—, —N(—Ra)— or —N(—Ra)SO2N(—Rb)—; R1 is independently a hydrogen atom, a hydroxyl group, or substituted or unsubstituted group selected from C1-6 alkyl group, heterocyclic group, aryl group, C3-8 cycloalkyl group and C3-8 cycloalkenyl group; or salt or prodrug thereof.

Abstract: According to the present invention, a compound represented by formula (I): wherein Q is: A is a hydrogen atom, a halogen atom, —ORa or a C1-4 alkyl group which may be substituted by one or more halogen atoms; E is independently selected from a C1-6 alkyl group; m is selected from integers from 0 to 3; R2 and R3 are independently selected from a C1-6 alkyl group; X1 and X2 are independently selected from O and S; Y is selected from an arylene group and a divalent 5- or 6-membered monocyclic or 8- to 10-membered condensed heterocyclic group, wherein the arylene group and the heterocyclic group may be substituted by 1 to 3 substituents independently selected from E1; E1 is independently selected from a hydroxyl group, a halogen atom, a C1-4 alkyl group, a cyano group, a C1-4 alkoky group, a carbamoyl group, a C1-4 alkylcarbamoyl group, a di(C1-4 alkyl)carbamoyl group, an amino group, a C1-4 alkylamino group, a di(C1-4 alkylamino group, a sulfamoyl group, a C1-4 alkylsulfamoyl group and a di(C1-4 alkyl)su

Abstract: A plurality of pixel portions (12) are formed on a silicon substrate (11). A photoelectric converter portion (10) constituting each of the pixel portions (12) is electrically isolated by an element isolation portion (13) comprising an insulating film formed on the silicon substrate (11). The photoelectric converter portion (10) partitioned by the element isolation portion (13) is so formed that a crystal orientation of the sides in contact with the element isolation portion (13) corresponds to a <00-1> direction. This makes it possible to reduce dark current caused by stress in the vicinity of the interface of the element isolation portion (13) and maintain high sensitivity even if the pixel portions (12) are made smaller in size.

Abstract: An antenna apparatus includes a base member that has an antenna unit and a loop pattern. The loop pattern is wound in such a manner that a magnetic field of the loop pattern is generated along the same direction as that of the antenna unit. Additionally, the loop pattern is formed by a plurality of loops connected parallel to each other.

Abstract: An object of the present invention is to provide an embossed crepe paper which can clearly be formed into fine embossed shapes, and is excellent in the fluffy feel and therefore excellent in such as absorbency for fats. As a means of achieving this object, the method for manufacturing an embossed crepe paper, according to the present invention, is a method for manufacturing an embossed crepe paper comprising a step of embossing a raw crepe paper, wherein: a raw paper having a basis weight of 6 to 28 g/m2 is used as the raw crepe paper; and the embossing step includes the steps of: (a) supplying the raw crepe paper with water in an amount of 0.1 to 100 weight % based on the basis weight to thereby put the raw crepe paper in a wet condition; (b) embossing the wet-conditioned raw crepe paper; and (c) drying the embossed wet-conditioned raw crepe paper.

Abstract: An object of the present invention is to provide an embossed crepe paper which can clearly be formed into fine embossed shapes, and is excellent in the fluffy feel and therefore excellent in such as absorbency for fats. As a means of achieving this object, the method for manufacturing an embossed crepe paper, according to the present invention, is a method for manufacturing an embossed crepe paper comprising a step of embossing a raw crepe paper, wherein: a raw paper having a basis weight of 6 to 28 g/m2 is used as the raw crepe paper; and the embossing step includes the steps of: (a) supplying the raw crepe paper with water in an amount of 0.1 to 100 weight % based on the basis weight to thereby put the raw crepe paper in a wet condition; (b) embossing the wet-conditioned raw crepe paper; and (c) drying the embossed wet-conditioned raw crepe paper.