Patents by Inventor Kenji Uchimura
Kenji Uchimura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7935792Abstract: A polypeptide of N-acetylglucosamine-6-O-sulfotransferase and a DNA encoding the peptide are provided. The polypeptide is (a) or (b) below: (a) a polypeptide having the amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide which includes an amino acid sequence including substitution, deletion, insertion or transposition of one or a few amino acids in the amino acid sequence of (a) and which has an enzymatic activity to transfer a sulfate group from a sulfate group donor to a hydroxyl group at 6 position of an N-acetylglucosamine residue located at a non-reducing end of an oligosaccharide represented the formula I: GlcNAc?1-3Gal?1-4GlcNAc??(I) where GlcNAc represents an N-acetyl-glucosamine residue, Gal represents a galactose residue, ? 1-3 represents a ? 1-3 glycosidic linkage, and ? 1-4 represents a ? 1-4 glycosidic linkage.Type: GrantFiled: August 19, 2008Date of Patent: May 3, 2011Assignee: Aichi PrefectureInventor: Kenji Uchimura
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Publication number: 20100137564Abstract: A polypeptide of N-acetylglucosamine-6-O-sulfotransferase and a DNA encoding the peptide are provided. The polypeptide is (a) or (b) below: (a) a polypeptide having the amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide which includes an amino acid sequence including substitution, deletion, insertion or transposition of one or a few amino acids in the amino acid sequence of (a) and which has an enzymatic activity to transfer a sulfate group from a sulfate group donor to a hydroxyl group at 6 position of an N-acetylglucosamine residue located at a non-reducing end of an oligosaccharide represented the formula I: GlcNAc?1-3Gal?1-4GlcNAc??(I) where GlcNAc represents an N-acetyl-glucosamine residue, Gal represents a galactose residue, ? 1-3 represents a ? 1-3 glycosidic linkage, and ? 1-4 represents a ? 1-4 glycosidic linkage.Type: ApplicationFiled: August 19, 2008Publication date: June 3, 2010Applicant: Aichi PrefectureInventors: Kenji Uchimura, Hideki Muramatsu, Kenji Kadomatsu, Reiji Kannagi, Osami Habuchi, Takashi Muramatsu
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Publication number: 20100015632Abstract: The present invention provides a method for examining colorectal cancer and colorectal adenoma, which enables to detect colorectal cancer patients and patients at high risk of colorectal cancer at a high probability and is useful for diagnosis of colorectal cancer and colorectal adenoma, and provides the examination reagents thereof. There are significant differences in the distribution of GlcNAc-6-sulfotransferase isozymes, sulfation enzymes of sugar residues, among non-cancer colorectal tissues, colorectal cancer tissues and colorectal adenoma tissues. Furthermore, colorectal cancers and adenomas are detected specifically by assaying a definite range of GlcNAc-6-sulfated sugar residues in tissues from patients or feces samples. MECA-79 antibody (Pharmingen, catalog No.Type: ApplicationFiled: September 28, 2009Publication date: January 21, 2010Applicant: Japan Science and Technology AgencyInventors: Reiji Kannagi, Mineko Izawa, Takashi Muramatsu, Kenji Uchimura, Hideaki Hosokawa
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Patent number: 7601348Abstract: The present invention provides a method for examining colorectal cancer and colorectal adenoma, which enables to detect colorectal cancer patients and patients at high risk of colorectal cancer at a high probability and is useful for diagnosis of colorectal cancer and colorectal adenoma, and provides the examination reagents thereof. The present inventors discovered that there are significant differences in the distribution of GlcNAc-6-sulfotransferase isozymes, sulfation enzymes of sugar residues, among non-cancer colorectal tissues, colorectal cancer tissues and colorectal adenoma tissues. Furthermore the inventors applied the discovery to diagnosis and found that colorectal cancers and adenomas are detected specifically by assaying a definite range of GlcNAc-6-sulfated sugar residues in tissues from patients or feces samples. MECA-79 antibody (Pharmingen, catalog No.Type: GrantFiled: July 9, 2004Date of Patent: October 13, 2009Assignees: Japan Science & Technology Agency, Local Government of Aichi Prefecture, Wako Pure Chemical Industries, Ltd.Inventors: Reiji Kannagi, Mineko Izawa, Takashi Muramatsu, Kenji Uchimura, Hideaki Hosokawa
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Publication number: 20070196874Abstract: The present invention provides a method for examining colorectal cancer and colorectal adenoma, which enables to detect colorectal cancer patients and patients at high risk of colorectal cancer at a high probability and is useful for diagnosis of colorectal cancer and colorectal adenoma, and provides the examination reagents thereof. The present inventors discovered that there are significant differences in the distribution of GlcNAc-6-sulfotransferase isozymes, sulfation enzymes of sugar residues, among non-cancer colorectal tissues, colorectal cancer tissues and colorectal adenoma tissues. Furthermore the inventors applied the discovery to diagnosis and found that colorectal cancers and adenomas are detected specifically by assaying a definite range of GlcNAc-6-sulfated sugar residues in tissues from patients or feces samples. MECA-79 antibody (Pharmingen, catalog No.Type: ApplicationFiled: July 9, 2004Publication date: August 23, 2007Inventors: Reiji Kannagi, Mineko Izawa, Takashi Muramatsu, Kenji Uchimura, Hideaki Hosokawa
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Publication number: 20050208631Abstract: A polypeptide of N-acetylglucosamine-6-O-sulfotransferase and a DNA encoding the peptide are provided. The polypeptide is (a) or (b) below: (a) a polypeptide consisting of an amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide which comprises an amino acid sequence including substitution, deletion, insertion or transposition of one or few amino acids in the amino acid sequence of (a) and which has an enzymatic activity to transfer a sulfate group from a sulfate group donor to a hydroxyl group at 6 position of an N-acetylglucosamine residue located at a non-reducing end of an oligosaccharide represented by the formula I: GlcNAc?1-3Gal ?1-4GlcNAc??(I) wherein GlcNAc represents an N-acetylglucosamine residue, Gal represents a galactose residue, ?1-3 represents a ?1-3 glycosidic linkage, and ?1-4 represents a ?1-4 glycosidic linkage.Type: ApplicationFiled: October 15, 2004Publication date: September 22, 2005Inventors: Kenji Uchimura, Hideki Muramatsu, Kenji Kadomatsu, Reiji Kannagi, Osami Habuchi, Takashi Muramatsu
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Publication number: 20050142644Abstract: Apolypeptide of N-acetylglucosamine-6-O-sulfotransferase and a DNA encoding the peptide are provided. The polypeptide is (a) or (b) below: (a) a polypeptide consisting of an amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide which comprises an amino acid sequence including substitution, deletion, insertion or transposition of one or few amino acids in the amino acid sequence of (a) and which has an enzymatic activity to transfer a sulfate group from a sulfate group donor to a hydroxyl group at 6 position of an N-acetylglucosamine residue located at a non-reducing end of an oligosaccharide represented by the formula I: GlcNAc?1-3Gal?1-4GlcNAc ??(I) wherein GlcNAc represents an N-acetylglucosamine residue, Gal represents a galactose residue, ?1-3 represents a ?1-3 glycosidic linkage, and ?1-4 represents a ?1-4 glycosidic linkage.Type: ApplicationFiled: October 15, 2004Publication date: June 30, 2005Inventors: Kenji Uchimura, Hideki Muramatsu, Kenji Kadomatsu, Reiji Kannagi, Osami Habuchi, Takashi Muramatsu
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Publication number: 20030008366Abstract: Apolypeptide of N-acetylglucosamine-6-O-sulfotransferase and a DNA encoding the peptide are provided.Type: ApplicationFiled: August 5, 2002Publication date: January 9, 2003Inventors: Kenji Uchimura, Hideki Muramatsu, Kenji Kadomatsu, Reiji Kannagi, Osami Habuchi, Takashi Muramatsu
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Patent number: 6455289Abstract: Apolypeptide of N-acetylglucosamine-6-O-sulfotransferase and a DNA encoding the peptide are provided. The polypeptide is (a) or (b) below: (a) a polypeptide consisting of an amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide which comprises an amino acid sequence including substitution, deletion, insertion or transposition of one or few amino acids in the amino acid sequence of (a) and which has an enzymatic activity to transfer a sulfate group from a sulfate group donor to a hydroxyl group at 6 position of an N-acetylglucosamine residue located at a non-reducing end of an oligosaccharide represented by the formula I: GlcNAc&bgr;1-3Gal&bgr;1-4GlcNAc (I) wherein GlcNAc represents an N-acetylglucosamine residue, Gal represents a galactose residue, &bgr;1-3 represents a &bgr;1-3 glycosidic linkage, and &bgr;1-4 represents a &bgr;1-4 glycosidic linkage.Type: GrantFiled: December 23, 1999Date of Patent: September 24, 2002Assignee: Seikagaku CorporationInventors: Kenji Uchimura, Hideki Muramatsu, Kenji Kadomatsu, Reiji Kannagi, Osami Habuchi, Takashi Muramatsu
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Patent number: 6037159Abstract: Apolypeptide of N-acetylglucosamine-6-O-sulfotransferase and a DNA encoding the peptide are provided. The polypeptide is (a) or (b) below:(a) a polypeptide consisting of an amino acid sequence represented by SEQ ID NO: 2; or(b) a polypeptide which comprises an amino acid sequence including substitution, deletion, insertion or transposition of one or few amino acids in the amino acid sequence of (a) and which has an enzymatic activity to transfer a sulfate group from a sulfate group donor to a hydroxyl group at 6 position of an N-acetylglucosamine residue located at a non-reducing end of an oligosaccharide represented by the formula I:GlcNAc.beta.1-3Gal.beta.1-4GlcNAc (I)wherein GlcNAc represents an N-acetylglucosamine residue, Gal represents a galactose residue, .beta.1-3 represents a .beta.1-3 glycosidic linkage, and .beta.1-4 represents a .beta.1-4 glycosidic linkage.Type: GrantFiled: March 5, 1999Date of Patent: March 14, 2000Assignee: Seikagaku CorporationInventors: Kenji Uchimura, Hideki Muramatsu, Kenji Kadomatsu, Reiji Kannagi, Osami Habuchi, Takashi Muramatsu