Abstract: A convenient, rapid, and highly sensitive protein detection method is provided. According to the present invention, an easily water-soluble compound of formula I is provided: [wherein, R1 and R2 are same or different, each of which is an aryl or heteroaryl group substituted with one or more anionic substituents].

Abstract: The object of the present invention is to inject smoothly a precursor to be a support and make an excellent support in which a boundary between a separation gel and a concentration gel after the injection is not ill-defined in the cassette which is made by combining two plates made of a synthetic resin, and in order to achieve the object, the present invention provides an electrophoresis cassette made by combining plates made of a synthetic resin which has a cavity for forming a support, wherein the surface of the plate which contacts with the support is covered with a SiOx film, and the SiOx film has a contact angle to water of 30° or less, and preferably 10° or less.

Abstract: The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; R2 is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, an optionally substituted aryl group, an optionally substituted heterocycloalkyl group, or an optionally substituted aromatic heterocyclic group; T is an oxygen atom, a sulfur atom, a sulfonyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof.

Abstract: A method of separating a protein by gel electrophoresis, which comprises a staining step for bringing a protein-containing sample into contact with a staining liquid containing a staining agent, a surfactant and a buffer solution, and an electrophoresis step for subjecting the protein-containing sample after the staining step to gel electrophoresis. According to the present invention, using a staining liquid containing a surfactant such as SDS and the like, a protein-containing sample can be stained in a short time, and can develop color with high sensitivity. In addition, since an excess staining agent migrates earlier than protein by electrophoresis, a washing operation is not necessary. Furthermore, by staining, after the first dimension electrophoresis, with a staining liquid containing a surfactant such as SDS and the like, the second dimension electrophoresis can be performed immediately.

Abstract: Aimed at readily and exactly separate 8-hydroxy-2?-deoxyguanosine (8-OHdG) contained in a sample, a column packing material used for separating 8-OHdG, which contains a packing material composed of a material having a straight-chain hydrocarbon group having 6 or more and 30 or less carbon atoms as a functional group, and having a carbon content over the surface of carrier of 18% or less by element ratio, wherein the packing material contains 1 cumulative percent or more and 20 cumulative percent or less, on the particle-count basis, of particles having a circle-equivalent diameter, measured using a flow-type particle image analyzer, of 0.5 ?m or larger and 10 ?m or smaller, is used.

Abstract: As a method for considering the adverse influence of the stresses caused form the pad, two sorts of methods are provided. As one method, while delay variation values of cells caused by an adverse influence of stresses are calculated, the calculated delay variation values are applied to the cells so as to perform a timing analysis, and the like by considering the adverse influence of the stresses. Then, in order that a flip chip type LSI is designed by employing a result of the above-described analysis in such a manner that the adverse influence of the stresses applied from the pad is not given to vias, wiring lines, and cells located under the pad, such a physical structure that no via is arranged under the pad is employed.

Abstract: With the use of a chip (4) for electrophoresis and transfer including a transfer membrane (1) and an electrophoretic gel that is integrated with the transfer membrane (1), separation of a sample by electrophoresis and transfer of the sample separated to the transfer membrane (1) are carried out consecutively. This allows molecules separated on the gel by electrophoresis to be accurately transferred to the transfer membrane.

Abstract: A method for analyzing proteins with the use of electrophoresis is provided, which makes it possible to rapidly and conveniently analyze a great variety of proteins with high sensitivity. The method for analyzing a protein in a sample comprises setting a sample in a carrier for electrophoresis, performing electrophoresis for the sample using a buffer for electrophoresis in which a labeling compound represented by formula I: wherein R1 is an aryl group or a heteroaryl group that may be substituted, R2 is a heterocyclic group that may be substituted, and n is an integer between 1 and 5, is dissolved, and then detecting a complex of the compound of formula I and the protein via spectrophotometrical measurement.

Abstract: An applicator to be used with first and second liquid-containing syringes comprises an applicator main body for receiving the syringes, a gas flow path adapted to be connected to a gas supply for supplying a gas, a nozzle through which is discharged the gas and the liquids in the syringes, an operation part adapted to be pressed to operate pushers of the syringes, and an opening and closing mechanism in the operation part for shutting off/opening the gas flow path. The opening and closing mechanism is operable to open the gas flow path in synchronization with the pressing operation by the operation part.

Abstract: A device for electrophoresis applies a voltage to a medium in contact with a plurality of electric conductors so that a potential of adjacent conductors is within a certain range. This allows preventing decline in electrophoresis speed. A device for electrophoresis and transfer includes an electrode having a plurality of electrode regions being insulated one another and arranged in a specific direction. This allows providing a practical and easy-to-use device for electrophoresis and transfer. A device for transfer alters an applied voltage or applied voltage duration to a certain position to another position. This allows improving transfer efficiency.

Abstract: A sprayer includes a nozzle through which gas is to be ejected with positiveness and uniformity. The sprayer is provided with a nozzle having inner tubes through the interior of which liquid is to pass and an outer tube receiving the inner tubes therein and allowing gas to pass through a space defined with the inserted inner tubes. The inner tubes have respective liquid orifices through which liquids are to be ejected. The outer tube is arranged therein with the liquid orifices and a gas orifice for ejecting gas. When the nozzle is viewed from front, the outer peripheries of the liquid orifices each assume a circular form while the inner peripheries of the gas orifices are differently shaped to provide plural point contact between the outer periphery of the liquid orifice and the inner periphery of the gas orifice.

Abstract: Provided is a thin film magnetic head capable of suppressing an occurrence of a track erase, decreasing an influence on a magnetoresistive element caused by a magnetic flux generated from a thin film coil, and further decreasing the parasitic capacity. The thin film magnetic head has, in order in a stacked direction, a first magnetic shield layer, a magnetoresistive element, a second magnetic shield layer, a third magnetic shield layer, a main magnetic pole layer and a return yoke layer. A width in a track width direction of at least one of the first and the second magnetic shield layers is smaller than widths in a track width direction of the third magnetic shield layer and the return yoke layer.

Abstract: A thin-film magnetic head includes a first magnetic layer, a flat, spiral-shaped coil, a toroidal-shaped insulating layer covering the coil, and a second magnetic layer touching the insulating layer and disposed to sandwich part of the coil between itself and the first magnetic layer. The second magnetic layer has a recessed portion that enters a space inside the insulating layer. In the recessed portion, the bottom surface of the second magnetic layer includes a first flat portion a part of which touches the top surface of the first magnetic layer, while the top surface of the second magnetic layer includes a second flat portion located in the space and substantially parallel to the first flat portion. In a cross section that divides each of the first and second magnetic layers into two equal portions, the second flat portion is 0.

Abstract: A sprayer includes first and second syringes that respectively supply first and second liquids, at least one orifice at which the first and second liquids, or a mixture of such liquids, are ejected, and first and second passages through which the first and second liquids are respectively fed toward the nozzle. At least one of the passages is provided with a deformable volume changer adapted to deform to change the internal capacity or volume. A deformer operates to deform the volume changer, and the volume of the volume changer is ultimately allowed to expand so as to have a larger volume in a state in which liquid ejection ceases as compared to during ejection.

Abstract: A magnetic head incorporates: a medium facing surface; a coil; a pole layer; first and second shields disposed to sandwich the pole layer therebetween; a first gap layer disposed between the first shield and the pole layer; a second gap layer disposed between the second shield and the pole layer; and a substrate. The first shield is located closer to the substrate than the second shield. The first shield has a first layer and a second layer disposed between the first layer and the first gap layer.

Abstract: A magnetic head incorporates: a medium facing surface; a coil; a pole layer; first and second shields disposed to sandwich the pole layer therebetween; a first gap layer disposed between the first shield and the pole layer; a second gap layer disposed between the second shield and the pole layer; and a substrate. The first shield is located closer to the substrate than the second shield. The magnetic head further incorporates an antireflection film disposed between the first shield and the first gap layer or between the first gap layer and the pole layer. The pole layer is formed by frame plating.

Abstract: An operational amplifier with a broad applicable band and little disturbing noise which is capable of preventing oscillation even when used in connection with a negative feedback path. The operational amplifier amplifies a difference between two input voltage signals to a non-inverting input terminal and an inverting input terminal and outputs the amplified difference to an output terminal. The operational amplifier includes an input voltage/current conversion stage which outputs, to the non-inverting input terminal and the inverting input terminal, a current signal having a difference current component in accordance with the difference between the two input voltage signals; a current amplification stage which performs current amplification on the current signal outputted from the input voltage/current conversion stage; and an output buffer stage which converts, into a voltage signal, the output current signal from the current amplification stage and applies the voltage signal to the output terminal.

Abstract: Urea derivatives represented by the following general formula (I): which have an agonism of V2 receptor, are useful as agents for the treatment or prevention of diabetes insipidus, nocturia, nocturnal enuresis, overactive bladder or the like.

Abstract: For reducing various adverse effects due to provision of a low-pass filter, while suppressing an oscillation generated therein, there is provide a feedback circuit, having at least one operational amplifier, having a low-pass filter in an output portion thereof, for feeding a signal from the output portion back thereto, including: a first feedback circuit portion for negatively feeding a signal from an input terminal of the low-pass filter back to an inverted input terminal of the operational amplifier; and a second feedback circuit portion for negatively feeding a signal from an output terminal of the low-pass filter back to the inverted input terminal of the operational amplifier.

Abstract: A present invention provides aromatic amide derivatives which have an agonism of V2 receptor, are useful as agents for the treatment or prevention of diabetes insipidus, nocturia, nocturnal enuresis, overactive bladder or the like, and are represented by the general formula (I): wherein R1 represents a hydrogen atom or a C1-6 alkyl group which may have a substituent, R2 is a hydrogen atom or a C1-6 alkyl group, R3 is a hydrogen atom, a C1-6 alkyl group or the like, R4, R5 and R6 are independently a hydrogen atom, a halogen atom or the like, R7 is a hydrogen atom, a heteroaryl group which may have a substituent, a C3-8 cycloalkyl group, an amino group which may have a substituent or a C1-6 alkoxy group which may have a substituted group; M1 is a single bond, a C1-4 alkylene group or the like Y is N or CRF (in the formula, RF represents a hydrogen atom, a C1-6 alkyl group or the like or a pharmaceutically acceptable salt thereof, or a prodrug thereof, or pharmaceutical compositions comprising the same an