Abstract: A substrate processing method includes: (A) preparing a substrate, on which a high-dielectric film having a higher permittivity than a SiO2 film is formed; (B) supplying, to the substrate, a metal solution containing a second metal element having a higher electronegativity or a lower valence than a first metal element contained in the high-dielectric film; and (C) forming a doping layer, in which the first metal element is substituted with the second metal element, on a surface of the high-dielectric film.

Abstract: According to an aspect of the present invention, there is provided a filter including: a belt shaped frame formed of a resin, an opening being provided inside the frame; a pair of link portions formed on the frame at both distal ends thereof to be engagable with each other; and a filtering member provided in the opening, wherein the frame is formed to have a flat plate shape or a curved shape that has a center angle equal to or less than 180 degrees in a state where the pair of link portions are not engaged, and wherein a plurality of grooves are formed on at least one surface of the frame at intervals along the longitudinal direction.

Abstract: A Process for production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which comprises using as a starting compound as a (phenylthio)acetic acid derivative or salts thereof represented by the general formula: wherein X1 represents a halogen atom, is useful as a safe process for mass production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which is useful as a remedy for disease of central and peripheral nerve.

Abstract: Disclosed is an organic amine salt of 6-fluoro-3-hydroxy-2-pyrazinecarbonitrile, which is excellent in crystallinity and useful as a production intermediate for 6-fluoro-3-hydroxy-2-pyrazinecarboxamide.

Abstract: A 6-(halomethyl)-1,2-benzisoxazol-3(2H)-one derivative represented by the formula: wherein R5 is a methyl group that is substituted with one or more optionally substituted phenyl groups, or an optionally substituted oxygen-containing heterocyclic group; and X is a halogen atom.

Abstract: A 6-(halomethyl)-1,2-benzisoxazol-3(2H)-one derivative represented by the formula: wherein R5 is a methyl group that is substituted with one or more optionally substituted phenyl groups, or an optionally substituted oxygen-containing heterocyclic group; and X is a halogen atom.

Abstract: A preparation method using as an intermediate 6-(halomethyl)-1,2-benzisoxazol-3(2H)-one derivative represented by general formula wherein R5 is a methyl group that is substituted with one or more optionally substituted phenyl groups, or an optionally substituted oxygen-containing heterocyclic group; X represents a halogen atom, can be used as a method for safely and easily preparing 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid, which is useful as an antirheumatic agent, with a high yield.

Abstract: The crystal of 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid having peaks at the position of 14.0, 16.0, 23.3, 23.7 and 26.3° and the crystal of 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid having peaks at the position of 14.6, 23.1, 24.7, 25.6 and 26.0° on 2? of diffraction angle in a powder X-ray diffraction pattern have a small specific volume, are hard to be charged with electricity, are easily handled and are useful for an active pharmaceutical ingredient of excellent anti-rheumatic agents.

Abstract: A Process for production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which comprises using as a starting compound as a (phenylthio)acetic acid derivative or salts thereof represented by the general formula: wherein X1 represents a halogen atom, is useful as a safe process for mass production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which is useful as a remedy for disease of central and peripheral nerve.

Abstract: A Process for production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which comprises using as a starting compound as a (phenylthio)acetic acid derivative or salts thereof represented by the general formula: wherein X1 represents a halogen atom, is useful as a safe process for mass production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which is useful as a remedy for disease of central and peripheral nerve.

Abstract: Disclosed is an organic amine salt of 6-fluoro-3-hydroxy-2-pyrazinecarbonitrile, which is excellent in crystallinity and useful as a production intermediate for 6-fluoro-3-hydroxy-2-pyrazinecarboxamide.

Abstract: The crystal of 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid having peaks at the position of 14.0, 16.0, 23.3, 23.7 and 26.3° and the crystal of 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid having peaks at the position of 14.6, 23.1, 24.7, 25.6 and 26.0° on 2? of diffraction angle in a powder X-ray diffraction pattern have a small specific volume, are hard to be charged with electricity, are easily handled and are useful for an active pharmaceutical ingredient of excellent anti-rheumatic agents.

Abstract: A preparation method using as an intermediate 6-(halomethyl)-1,2-benzisoxazol-3(2H)-one derivative represented by general formula wherein R5 is a methyl group that is substituted with one or more optionally substituted phenyl groups, or an optionally substituted oxygen-containing heterocyclic group; X represents a halogen atom, can be used as a method for safely and easily preparing 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid, which is useful as an antirheumatic agent, with a high yield.

Abstract: According to an aspect of the present invention, there is provided a filter including: a belt shaped frame formed of a resin, an opening being provided inside the frame; a pair of link portions formed on the frame at both distal ends thereof to be engagable with each other; and a filtering member provided in the opening, wherein the frame is formed to have a flat plate shape or a curved shape that has a center angle equal to or less than 180 degrees in a state where the pair of link portions are not engaged, and wherein a plurality of grooves are formed on at least one surface of the frame at intervals along the longitudinal direction.

Abstract: A Process for production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which comprises using as a starting compound as a (phenylthio)acetic acid derivative or salts thereof represented by the general formula: wherein X1 represents a halogen atom, is useful as a safe process for mass production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which is useful as a remedy for disease of central and peripheral nerve.

Abstract: Process for producing a 7-bromoquinolone-carboxylic acid derivative of the following formula or its salt by reacting a 2,4-dibromo-3-hydroxybenzoic acid ester compound of the formula R7a-x to obtain a 3-alkoxy-2,4-dibromobenzoic acid ester, subjecting the 3-alkoxy-2,4-dibromobenzoic acid ester to elimination reaction of the carboxyl-protecting group to obtain a 3-alkoxy-2,4-dibromobenzoic acid, subjecting the 3-alkoxy-2,4-dibromobenzoic acid to ketoesterification reaction to obtain a 3-alkoxy-2,4-dibromobenyolacetic acid ester, reacting the 3-alkoxy-2,4-dibromobenzoylacetic acid ester with an orthoester or an acetal, then reacting the reaction product with a compound of the formula R2— NH or its salt to obtain a 2-(3-alkoxy-2,4-dibromobenzoyl)-3-substituted aminoacrylic acid ester and subjecting the 2-(3-alkoxy-2,4-dibromobenzoyl)-3-substituted aminoacrylic acid ester to ring-closing reaction, and products thereof.

Abstract: A clip which is inserted and engaged in an attaching hole includes a proximal portion for abutting against one surface around a peripheral edge of the attaching hole, a stem extending from the proximal portion and adapted to be inserted in the attaching hole, and a pair of resiliently retaining pieces extending from a distal end portion of the stem toward the proximal portion in the form of an anchor and adapted to engage an edge of the attaching hole in another surface. At least one projection is formed on a side wall of the stem opposing the resiliently retaining piece, and an amount of deflection of the resiliently retaining piece is restricted by the projection.

Abstract: An allowable angle of a float valve member with respect to a valve case is so set that a deformed direction, as caused by a gate position at a injection molding time, of a inner circumference of a communication hole of the valve case with respect to a roundness and a deformed direction, as caused by a gate position at a injection molding time, of an outer circumference of a crest portion of the float valve member with respect to the roundness may be substantially aligned. Between the valve case and the float valve member, there is an interposed angle regulating unit for preventing the angle of the float valve member with respect to the valve case from varying over the allowable angle.

Abstract: A clip which is inserted and engaged in an attaching hole includes: a proximal portion 6 for abutting against one surface around a peripheral edge of the attaching hole; a stem extending from the proximal portion and adapted to be inserted in the attaching hole; and a pair of resiliently retaining pieces extending from a distal end portion of the stem toward the proximal portion in the form of an anchor and adapted to engage an edge of the attaching hole in another surface. At least one projection is formed on a side wall of the stem opposing the resiliently retaining piece, and an amount of deflection of the resiliently retaining piece is restricted by the projection.

Abstract: A resin member has a first barrel member 30, which can be welded to the fuel tank, and a second barrel member having a higher melting temperature than the first barrel member. The first barrel member is joined to the outer circumference of the second barrel member and protrudes at one axial end. The second barrel member protrudes at the other axial end. A bolt is inserted from one end where the first barrel member protrudes through the second barrel member out of an end face where the second barrel member protrudes. The first barrel member of the resin member is welded to the fuel tank. The bolt is inserted into a mounting hole of the heat insulation plate and securely fastened. A flange spreading diametrically is preferably formed on a protruding end face of the second barrel member.