Abstract: The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: wherein each symbol is as defined in the SPECIFICATION.

Abstract: The invention provides a cut-out method capable of suppressing production of a byproduct, wherein the object RNA oligonucleotide is not cleaved from a universal linker, which is produced in cutting out the object RNA oligonucleotide from the universal support, and capable of increasing the yield of the object RNA oligonucleotide. The RNA oligonucleotide cut-out method includes a step of bringing a universal support supporting an RNA oligonucleotide in contact with an aqueous solution containing alkylamine and a monovalent inorganic salt.

Abstract: An information processing apparatus includes a packet preprocessing unit configured to generate a packet process request when a packet is received; a CPU core configured to process the packet in response to the packet process request; a hardware element configured to generate a message including information identifying a predetermined event, in response to the predetermined event occurring in accordance with the processing of the packet, the hardware element being provided in the CPU core; and a message recording unit configured to record the message generated by the hardware element together with a count value of a timer.

Abstract: A performance profiling apparatus includes: a plurality of counters provided for a routine included in a program; a storage section configured to store an instruction of the program and an identification information indicating the routine of the program; a processor configured to read the instruction from the storage section and to execute a process according to the instruction; and a counter controller configured to, at the time of reading the instruction of the processor, receive the identification information of the instruction which is output from the storage section with the instruction and to instruct a first counter designated by the identification information to count up.

Abstract: The invention provides a cut-out method capable of suppressing production of a byproduct, wherein the object RNA oligonucleotide is not cleaved from a universal linker, which is produced in cutting out the object RNA oligonucleotide from the universal support, and capable of increasing the yield of the object RNA oligonucleotide. The RNA oligonucleotide cut-out method includes a step of bringing a universal support supporting an RNA oligonucleotide in contact with an aqueous solution containing alkylamine and a monovalent inorganic salt.

Abstract: The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: wherein each symbol is as defined in the SPECIFICATION.

Abstract: In a multicore system in which a plurality of CPUs each including a cache memory share one main memory, a write buffer having a plurality of stages of buffers each holding data to be written to the main memory and an address of a write destination is provided between the cache memory and the main memory, and at the time of a write to the write buffer from the cache memory, an address of a write destination and the addresses stored in the buffers are compared, and when any of the buffers has an agreeing address, data is overwritten to this buffer, and the buffer is logically moved to a last stage.

Abstract: An information processing apparatus includes a packet preprocessing unit configured to generate a packet process request when a packet is received; a CPU core configured to process the packet in response to the packet process request; a hardware element configured to generate a message including information identifying a predetermined event, in response to the predetermined event occurring in accordance with the processing of the packet, the hardware element being provided in the CPU core; and a message recording unit configured to record the message generated by the hardware element together with a count value of a timer.

Abstract: The present invention provides a porous resin bead of a copolymer composed of a monovinyl monomer unit and a crosslinking vinyl monomer unit, which has a group capable of binding with a carboxy group by a dehydration condensation reaction, wherein the amount of the crosslinking vinyl monomer is 18.5-55 mol % of the total monomer, and the median pore size of the porous resin bead is 60-300 nm.

Abstract: The present invention provides a solid-phase support for oligonucleotide synthesis for synthesizing long chain oligonucleotide, RNA oligonucleotide and modified oligonucleotide at high synthetic quantity and high purity with a low loading amount of a linker. Provided is a solid-phase support for oligonucleotide synthesis comprising a porous resin bead having a monovinyl monomer unit, a crosslinkable vinyl monomer unit and a polyethylene glycol unit and a cleavable linker loaded on its surface, the porous resin bead having a group capable of binding to a carboxy group by a dehydration condensation reaction on its surface, the cleavable linker having a carboxy group, wherein the carboxy group of the cleavable linker is bound to the group capable of binding to a carboxy group, by a dehydration condensation reaction, and a loading amount of the cleavable linker is 1 to 80 ?mol/g relative to the weight of the porous resin bead.

Abstract: When an invalidation request is inputted from another processing device, a cache controller registers a set of an invalidation request address which the invalidation request has and an identifier of the other processing device which outputted the invalidation request in an invalidation history table. When a central processing unit attempts to read data at a first address not stored in a cache memory, if the first address is registered in the invalidation history table, the cache controller outputs a coherent read request containing the first address to the other processing device indicated by the identifier of the other processing device which outputted the invalidation request corresponding to the first address, or if the first address is not registered in the invalidation history table, the cache controller outputs a coherent read request containing the first address to all other processing devices.

Abstract: A performance profiling apparatus includes: a plurality of counters provided for a routine included in a program; a storage section configured to store an instruction of the program and an identification information indicating the routine of the program; a processor configured to read the instruction from the storage section and to execute a process according to the instruction; and a counter controller configured to, at the time of reading the instruction of the processor, receive the identification information of the instruction which is output from the storage section with the instruction and to instruct a first counter designated by the identification information to count up.

Abstract: In a multicore system in which a plurality of CPUs each including a cache memory share one main memory, a write buffer having a plurality of stages of buffers each holding data to be written to the main memory and an address of a write destination is provided between the cache memory and the main memory, and at the time of a write to the write buffer from the cache memory, an address of a write destination and the addresses stored in the buffers are compared, and when any of the buffers has an agreeing address, data is overwritten to this buffer, and the buffer is logically moved to a last stage.

Abstract: The invention provides a universal linker capable of synthesizing nucleic acid having a hydroxy group at the 3? terminal, a universal support carrying the linker, and a synthesis method of nucleic acid using the universal support. The linker contains a compound represented by the formula wherein each symbol is as defined in the specification.

Abstract: The present invention relates to a porous resin bead containing a first aromatic monovinyl compound-divinyl compound-(meth)acrylonitrile-second aromatic monovinyl compound copolymer, in which the second aromatic monovinyl compound contains a group capable of binding with a carboxyl group by dehydration condensation reaction, and in which the porous resin bead has a swelling volume in acetonitrile of from 3 to 6 ml/g.

Abstract: The invention provides a universal linker capable of synthesizing nucleic acid having a phosphate group at the 3? terminal, a universal support carrying the linker, and a synthesis method of nucleic acid using the universal support. The linker for solid phase synthesis of nucleic acid contains a compound represented by at least one of the following formulae wherein each symbol is as defined in the specification.

Abstract: The present invention relates to a porous resin bead containing a first aromatic monovinyl compound-divinyl compound-(meth)acrylonitrile-second aromatic monovinyl compound copolymer, in which the second aromatic monovinyl compound contains a group capable of binding with a carboxyl group by dehydration condensation reaction, and in which the porous resin bead has a dry volume of from 2 to 3 ml/g.

Abstract: The present invention provides a solid-phase support for oligonucleotide synthesis for synthesizing long chain oligonucleotide, RNA oligonucleotide and modified oligonucleotide at high synthetic quantity and high purity with a low loading amount of a linker. Provided is a solid-phase support for oligonucleotide synthesis comprising a porous resin bead having a monovinyl monomer unit, a crosslinkable vinyl monomer unit and a polyethylene glycol unit and a cleavable linker loaded on its surface, the porous resin bead having a group capable of binding to a carboxy group by a dehydration condensation reaction on its surface, the cleavable linker having a carboxy group, wherein the carboxy group of the cleavable linker is bound to the group capable of binding to a carboxy group, by a dehydration condensation reaction, and a loading amount of the cleavable linker is 1 to 80 ?mol/g relative to the weight of the porous resin bead.

Abstract: The present invention provides porous resin beads containing an aromatic monovinyl compound-divinyl compound-(meth)acrylamide derivative copolymer. Preferably, the copolymer further contains as a structural unit a second aromatic monovinyl compound having a functional group capable of binding to a carboxyl group by a dehydrating condensation reaction.

Abstract: The present invention relates to a method for producing a porous resin particle containing an aromatic vinyl compound-aromatic divinyl compound copolymer having a hydroxyl group, the method including: dissolving a monomer mixture containing an aromatic vinyl compound, an aromatic divinyl compound and a (meth)acrylic acid ester having one hydroxyl group within the molecule thereof, and a polymerization initiator in an organic solvent to obtain a solution containing the monomer mixture and the polymerization initiator; suspending the solution in water in the presence of a dispersion stabilizer; and performing a suspension copolymerization. The method of the invention is capable of easily producing a porous resin particle containing an aromatic vinyl compound-aromatic divinyl compound copolymer having a hydroxyl group, that is used as a support for solid phase synthesis and enables efficient nucleic acid synthesis.