Patents by Inventor Kenko Uchida
Kenko Uchida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7879290Abstract: An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.Type: GrantFiled: February 21, 2008Date of Patent: February 1, 2011Assignee: Hitachi, Ltd.Inventors: Hideyuki Noda, Satoshi Ozawa, Masahiro Okanojo, Kenko Uchida
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Patent number: 7798981Abstract: A living body inspection apparatus including an oscillation coil which passes an AC current, a detection coil which detects an AC magnetic field generated from the detection coil, an amplification circuit which amplifies a voltage generated by the magnetic field induced by the detection coil, a detecting unit for detecting the output signal of the amplification circuit, a low pass filter to which the output signal of the detecting unit is input, a unit for setting the oscillation coil and detection coil in first and second regions of the living body, a recording unit for recording the output of the low pass filter while the first region and the second region of the living body are moving and a displaying unit for displaying the data recorded in the recording unit or results of analysis of the recorded data.Type: GrantFiled: November 7, 2008Date of Patent: September 21, 2010Assignee: Hitachi, Ltd.Inventors: Akihiko Kandori, Tsuyoshi Miyashita, Keiji Tsukada, Kenko Uchida, Hideo Kawaguchi, Minoru Sakairi
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Publication number: 20100167281Abstract: It is intended to provide an assay for the presence, absence or amount of a nucleic-acid fragment having a certain nucleotide sequence, for example, a polyA length, a difference in the number of repetition of a direct repeat sequence (e.g., microsatellite), single nucleotide substitution (or single nucleotide polymorphism), and nucleotide sequence insertion or deletion, and to provide a genetic testing using the same. The present invention relates to a nucleotide analysis method, comprising: hybridizing at least two probes to a nucleic-acid fragment; ligating the at least two probes using ligase; exchanging, to ATP, pyrophosphoric acid produced through the ligation reaction; and detecting chemiluminescence reaction dependent on the ATP.Type: ApplicationFiled: February 19, 2009Publication date: July 1, 2010Inventors: Maiko Tanabe, Chihiro Uematsu, Hirokazu Nishida, Kenko Uchida
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Patent number: 7737268Abstract: Disclosure is a method of separately recovering deoxyribonucleic acid and ribonucleic acid from a biological sample solution. They are separated and recovered from a single biological sample by controlling pH values, temperature, and/or concentration of cationic ions of a nucleic acid sample solution containing a caotropic agent. It is possible to easily and safely separate and recover deoxyribonucleic acid and ribonucleic acid from the single biological sample.Type: GrantFiled: May 19, 2004Date of Patent: June 15, 2010Assignee: Hitachi High-Technologies CorporationInventors: Norihito Kuno, Kenko Uchida
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Publication number: 20090189063Abstract: During the structural analysis of a protein or peptide by tandem mass spectroscopy, a peptide ion derived from a protein that has already been measured and that is expressed in great quantities is avoided as a tandem mass spectroscopy target. A peptide derived from a minute amount of protein, which has heretofore been difficult to analyze, can be automatically determined as a tandem mass spectroscopy target within the real time of measurement. Data concerning a protein that has already been measured and a peptide derived from the protein is automatically stored in an internal database. The stored data is collated with measured data with high accuracy to determine an isotope peak. In this way, the process of selecting a peptide peak that has not been measured as the target for the next tandem analysis can be performed within the real time of measurement and a redundant measurement of peptides derived from the same protein can be avoided.Type: ApplicationFiled: December 8, 2008Publication date: July 30, 2009Inventors: Akihiro Sano, Atsumu Hirabayashi, Yasushi Terui, Kinya Kobayashi, Kiyomi Yoshinari, Kenko Uchida, Toshiyuki Yokosuka
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Publication number: 20090111114Abstract: A method to extract RNA with high purity from biological materials containing RNA in a safe, rapid, and simple procedure and a method to analyze it are provided. The procedure includes the steps of mixing a biological material containing RNA with a predetermined concentration of a chaotropic agent and a predetermined concentration of an organic solvent, allowing the mixed solution to contact a nucleic acid-binding solid phase, washing the nucleic-acid binding solid-phase to which RNA is bound, and eluting RNA from the nucleic-acid binding solid-phase having the bound RNA. Furthermore, the obtained RNA is analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR) or the like.Type: ApplicationFiled: October 14, 2008Publication date: April 30, 2009Inventors: Yoshihiro Yamashita, Toshinari Sakurai, Norihito Kuno, Kenko Uchida, Toshiaki Yokobayashi
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Publication number: 20090069663Abstract: A living body inspection apparatus including an oscillation coil which passes an AC current, a detection coil which detects an AC magnetic field generated from the detection coil, an amplification circuit which amplifies a voltage generated by the magnetic field induced by the detection coil, a detecting unit for detecting the output signal of the amplification circuit, a low pass filter to which the output signal of the detecting unit is input, a unit for setting the oscillation coil and detection coil in first and second regions of the living body, a recording unit for recording the output of the low pass filter while the first region and the second region of the living body are moving and a displaying unit for displaying the data recorded in the recording unit or results of analysis of the recorded data.Type: ApplicationFiled: November 7, 2008Publication date: March 12, 2009Inventors: Akihiko Kandori, Tsuyoshi Miyashita, Keiji Tsukada, Kenko Uchida, Hideo Kawaguchi, Minoru Sakairi
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Publication number: 20090020555Abstract: The present invention provides an apparatus for efficiently transporting or dispensing transport objects including not only particles but also liquid samples. A liquid in a first liquid transport pipe (3) is fed at a liquid feed velocity (V1), and a liquid droplet is formed toward an open end of a second liquid transport pipe (4) disposed with an air gap (11) in between. The particle is released into the liquid droplet, so that the particle is enclosed in the liquid droplet. Suction with a liquid feed velocity (V2) is applied to the inside of the second liquid transport pipe. Since the relationship between V1 and V2 is V1<V2, the liquid droplet, after reaching the open end (10) of the second liquid transport pipe, is sheared off by suction, thereby forming a liquid section in the second liquid transport pipe.Type: ApplicationFiled: March 7, 2006Publication date: January 22, 2009Inventors: Hideyuki Noda, Yoshinobu Kohara, Kenko Uchida
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Patent number: 7473892Abstract: During the structural analysis of a protein or peptide by tandem mass spectroscopy, a peptide ion derived from a protein that has already been measured and that is expressed in great quantities is avoided as a tandem mass spectroscopy target. A peptide derived from a minute amount of protein, which has heretofore been difficult to analyze, can be automatically determined as a tandem mass spectroscopy target within the real time of measurement. Data concerning a protein that has already been measured and a peptide derived from the protein is automatically stored in an internal database. The stored data is collated with measured data with high accuracy to determine an isotope peak. In this way, the process of selecting a peptide peak that has not been measured as the target for the next tandem analysis can be performed within the real time of measurement and a redundant measurement of peptides derived from the same protein can be avoided.Type: GrantFiled: May 20, 2004Date of Patent: January 6, 2009Assignee: Hitachi High-Technologies CorporationInventors: Akihiro Sano, Atsumu Hirabayashi, Yasushi Terui, Kinya Kobayashi, Kiyomi Yoshinari, Kenko Uchida, Toshiyuki Yokosuka
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Patent number: 7455648Abstract: A living body inspection apparatus including an oscillation coil which passes an AC current, a detection coil which detects an AC magnetic field generated from the detection coil, an amplification circuit which amplifies a voltage generated by the magnetic field induced by the detection coil, a detecting unit for detecting the output signal of the amplification circuit, a low pass filter to which the output signal of the detecting unit is input, a unit for setting the oscillation coil and detection coil in first and second regions of the living body, a recording unit for recording the output of the low pass filter while the first region and the second region of the living body are moving and a displaying unit for displaying the data recorded in the recording unit or results of analysis of the recorded data.Type: GrantFiled: March 1, 2004Date of Patent: November 25, 2008Assignee: Hitachi, Ltd.Inventors: Akihiko Kandori, Tsuyoshi Miyashita, Keiji Tsukada, Kenko Uchida, Hideo Kawaguchi, Minoru Sakairi
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Publication number: 20080261294Abstract: An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.Type: ApplicationFiled: February 21, 2008Publication date: October 23, 2008Inventors: Hideyuki Noda, Satoshi Ozawa, Masahiro Okanojo, Kenko Uchida
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Publication number: 20080239311Abstract: In order to provide a fluorescence detection apparatus having a high sensitivity, a high processing capacity and a competitive edge in cost, the fluorescence detection apparatus according to this invention irradiate the sample with light so that the aspect ratio of the form of the irradiated region by light on the arrangement surface of the sample may be 1±0.1. The preferable form of irradiate region is not limited to one and varies to some extent depending on the item to be optimized. The form of irradiated region may be, for example, a circle, an equilateral triangle, a square, a regular hexagon and the like.Type: ApplicationFiled: March 19, 2008Publication date: October 2, 2008Inventors: Tsuyoshi SONEHARA, Takashi Anazawa, Kenko Uchida, Tomoyuki Sakai
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Publication number: 20070292897Abstract: There is provided a simple, inexpensive reaction analysis kit and system capable of performing highly sensitive, quantitative measurement. A chemical luminescence reaction is employed and a sensor element is used to detect the reaction in a highly sensitive manner. That is, a reaction detection plate is used to transmit a signal detected in the sensor element via a reader coil and a reader and then analyze the reaction. The reaction detection plate has a) a membrane, b) a first antibody impregnated section that is disposed such that it faces the membrane and holds a first labeled antibody that specifically binds to a substance to be analyzed, c) a second antibody immobilized section that is provided in part of the membrane and has an immobilized second antibody, the second antibody specifically binding to the substance to be analyzed, and d) a sensor element that is disposed such that it faces the second antibody immobilized section and includes a light detector and a signal transceiver.Type: ApplicationFiled: June 15, 2007Publication date: December 20, 2007Inventors: Yoshiaki Yazawa, Takashi Anazawa, Kenko Uchida
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Publication number: 20070207064Abstract: The invention provides a method in which an annular or spiral droplet holder formed of wire is used to hold a droplet in a state of being hung therefrom or being contained therein. A means for moving the droplet holder is added to the droplet holder to enable droplet transfer. To merge two droplets, they are brought into contact. To drip the droplet held by a droplet holder formed of wire, the droplet holder is deformed using an external force. A light path which passes through a droplet is set to enable optical measurement. The present invention enables inexpensive, simple droplet transfer. An inexpensive, simple configuration for handling droplets in the fields of chemical analysis, biochemical analysis, and automatic blood analysis can be realized according to the present invention.Type: ApplicationFiled: February 16, 2007Publication date: September 6, 2007Inventors: Yoshinobu Kohara, Masataka Shirai, Hideyuki Noda, Tomoyuki Sakai, Kenko Uchida
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Patent number: 7231241Abstract: Disclosed is a probe for biomeasurement by use of light capable of adjusting positions of incident points and detection points without changing the distance between the incident point and the detection point in accordance with the size of a subject's head, and an optical bioinstrumentation for living body using the probe. The distances between the incident points and the detection points are approximately the same. A gap is formed by removing part of connecting members, rotatable about the incident point and the detection point, around the subject head top portion. The size of the probe is changed by changing the distance between the incident points or the detection points around the gap.Type: GrantFiled: March 3, 2005Date of Patent: June 12, 2007Assignee: Hitachi, Ltd.Inventors: Yukiko Hirabayashi, Kenko Uchida
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Publication number: 20060122477Abstract: Disclosed is a probe for biomeasurement by use of light capable of adjusting positions of incident points and detection points without changing the distance between the incident point and the detection point in accordance with the size of a subject's head, and an optical bioinstrumentation for living body using the probe. The distances between the incident points and the detection points are approximately the same. A gap is formed by removing part of connecting members, rotatable about the incident point and the detection point, around the subject head top portion. The size of the probe is changed by changing the distance between the incident points or the detection points around the gap.Type: ApplicationFiled: March 3, 2005Publication date: June 8, 2006Inventors: Yukiko Hirabayashi, Kenko Uchida
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Publication number: 20050123965Abstract: A method to extract RNA with high purity from biological materials containing RNA in a safe, rapid, and simple procedure and a method to analyze it are provided. The procedure includes the steps of mixing a biological material containing RNA with a predetermined concentration of a chaotropic agent and a predetermined concentration of an organic solvent, allowing the mixed solution to contact a nucleic acid-binding solid phase, washing the nucleic-acid binding solid-phase to which RNA is bound, and eluting RNA from the nucleic-acid binding solid-phase having the bound RNA. Furthermore, the obtained RNA is analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR) or the like.Type: ApplicationFiled: November 5, 2004Publication date: June 9, 2005Inventors: Yoshihiro Yamashita, Toshinari Sakurai, Norihito Kuno, Kenko Uchida, Toshiaki Yokobayashi
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Publication number: 20050065422Abstract: A living body inspection apparatus including an oscillation coil which passes an AC current, a detection coil which detects an AC magnetic field generated from the detection coil, an amplification circuit which amplifies a voltage generated by the magnetic field induced by the detection coil, a detecting unit for detecting the output signal of the amplification circuit, a low pass filter to which the output signal of the detecting unit is input, a unit for setting the oscillation coil and detection coil in first and second regions of the living body, a recording unit for recording the output of the low pass filter while the first region and the second region of the living body are moving and a displaying unit for displaying the data recorded in the recording unit or results of analysis of the recorded data.Type: ApplicationFiled: March 1, 2004Publication date: March 24, 2005Inventors: Akihiko Kandori, Tsuyoshi Miyashita, Keiji Tsukada, Kenko Uchida, Hideo Kawaguchi, Minoru Sakairi
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Publication number: 20050063864Abstract: During the structural analysis of a protein or peptide by tandem mass spectroscopy, a peptide ion derived from a protein that has already been measured and that is expressed in great quantities is avoided as a tandem mass spectroscopy target. A peptide derived from a minute amount of protein, which has heretofore been difficult to analyze, can be automatically determined as a tandem mass spectroscopy target within the real time of measurement. Data concerning a protein that has already been measured and a peptide derived from the protein is automatically stored in an internal database. The stored data is collated with measured data with high accuracy to determine an isotope peak. In this way, the process of selecting a peptide peak that has not been measured as the target for the next tandem analysis can be performed within the real time of measurement and a redundant measurement of peptides derived from the same protein can be avoided.Type: ApplicationFiled: May 20, 2004Publication date: March 24, 2005Inventors: Akihiro Sano, Atsumu Hirabayashi, Yasushi Terui, Kinya Kobayashi, Kiyomi Yoshinari, Kenko Uchida
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Publication number: 20040235034Abstract: Disclosure is a method of separately recovering deoxyribonucleic acid and ribonucleic acid from a biological sample solution. They are separated and recovered from a single biological sample by controlling pH values, temperature, and/or concentration of cationic ions of a nucleic acid sample solution containing a caotropic agent. It is possible to easily and safely separate and recover deoxyribonucleic acid and ribonucleic acid from the single biological sample.Type: ApplicationFiled: May 19, 2004Publication date: November 25, 2004Applicant: Hitachi High-Technologies CorporationInventors: Norihito Kuno, Kenko Uchida