Patents by Inventor Kenneth A. Iczkowski

Kenneth A. Iczkowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymorphism in the macrophage migration inhibitory factor (MIF) gene as marker for prostate cancer
    Patent number: 7745121
    Abstract: The present invention relates to the risk assessment, detection, diagnosis, or prognosis of prostate cancer. More specifically, this invention relates to the detection of certain polymorphism in the promoter region of the MIF gene to determine the risk, detect, diagnose, or prognosticate prostate cancer. Applicants have discovered that the presence of a ?173C and/or ?749 (CATT)7 or more repeat predispose an individual to prostate cancer.
    Type: Grant
    Filed: May 23, 2006
    Date of Patent: June 29, 2010
    Assignee: The Department of Veterans Affairs
    Inventors: Katherine Siegler, Kenneth Iczkowski, Richard Bucala, Pedro L. Vera
  • Cd44 Variants As Therapeutic Targets
    Publication number: 20080171042
    Abstract: The present invention involves diagnostic and treatment methods for prostate cancer. We have shown that prostate cancer cells overexpress variant isoforms of CD44 (CD44v7-10). Overexpression is observed at the messenger RNA and protein levels. The present invention includes using diagnostic procedures such as RT-PCR and in situ hybridization to distinguish prostate cancer cells from benign prostate tissue. In addition, the present invention involves RNA interference (RNAi) targeted to a region of CD44v7-10 and to Muc18 as a treatment method for PC. We have shown that RNAi targeted to CD44v7-10 and to Muc 18 decreased invasiveness of two PC cell lines. Therapeutic methods of the present invention include gene therapy with RNAi, antisense, or ribozymes targeted against CD44v7-10 or Muc18 in cancer cells in vivo.
    Type: Application
    Filed: May 9, 2005
    Publication date: July 17, 2008
    Applicant: University of Florida Research Foundation, Inc.
    Inventors: Kenneth A. Iczkowski, Archangel Levi Omara-Opyene
  • Polymorphism in the macrophage migration inhibitory factor (MIF) gene as marker for prostate cancer
    Publication number: 20070048763
    Abstract: The present invention relates to the risk assessment, detection, diagnosis, or prognosis of prostate cancer. More specifically, this invention relates to the detection of certain polymorphism in the promoter region of the MIF gene to determine the risk, detect, diagnose, or prognosticate prostate cancer. Applicants have discovered that the presence of a ?173C and/or ?749 (CATT)7 or more repeat predispose an individual to prostate cancer.
    Type: Application
    Filed: May 23, 2006
    Publication date: March 1, 2007
    Inventors: Katherine Siegler, Kenneth Iczkowski, Richard Bucala, Pedro Vera