Abstract: An improved method for attaching a geosynthetic strip to a plurality of fact panels of a retaining wall. The method first begins by providing a plurality of stackable face panels, each face panel having a plurality of connector loops fixed with the back portion of the face panels. Each of the connector loops for a horizontal loop extending outwardly generally perpendicular to the back portion of the face panel. Next, a first tier of face panels is disposed at the bottom of the embankment being erected. Soil is then back-filled behind the first tier of panels to a level of the connector loops disposed within the first tier of face panels. A geosynthetic strip, which extends perpendicularly from the back portion of the face panels into the soil embankment, is positioned so that a plurality of geosynthetic strips aligns with the connection loops.

Abstract: The technology described herein relates to determination of fetal lung maturity, e.g. by non-invasive methods and methods of treatment and assays relating thereto.

Abstract: In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about 50 nm to about 500 nm.

Abstract: In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about 50 nm to about 500 nm.

Abstract: In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about 50 nm to about 500 nm.

Abstract: Disclosed are stable corticosteroid nanoparticulate formulations, methods of making and therapeutic uses thereof.

Abstract: Disclosed are stable corticosteroid nanoparticulate formulations, methods of making and therapeutic uses thereof.

Abstract: In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about 50 nm to about 500 nm.

Abstract: Pseudobase benzo[c]phenanthridines and the pharmaceutically acceptable salts thereof of Formula I are provided herein. The variables R, R1, R2, R3, and R4 are defined herein. Certain pseudobase benzo[c]phenanthridines provided herein act as prodrugs, targeting the parent benzo[c]phenanthridinium alkaloid to hydrophilic or hydrophobic regions in the body. Pharmaceutical compositions comprising a pseudobase benzo[c]phenanthridine and a carrier, excipient, or diluent are provided herein. Methods of treating or preventing microbial, fungal and or viral infections and methods of treating diseases and disorders responsive to protein kinase C modulation, topoisomerase I, and/or topoisomerase II modulation are also provided.

Abstract: Applicants have discovered a method for the stereoselective and regioselective synthesis of 3?-hydroxy, 3?-methyl-5?-pregnan-20-one (ganaxolone) comprising reacting 5?-pregnane-3,20-dione; with an organometallic methylating agent in an inert solvent to provide a compound of the formula

Abstract: In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about 50 nm to about 500 nm.

Abstract: Pseudobase benzo[c]phenanthridines and the pharmaceutically acceptable salts thereof of Formula I are provided herein. The variables R, R1, R2, R3, and R4 are defined herein. Certain pseudobase benzo[c]phenanthridines provided herein act as prodrugs, targeting the parent benzo[c]phenanthridinium alkaloid to hydrophilic or hydrophobic regions in the body. Pharmaceutical compositions comprising a pseudobase benzo[c]phenanthridine and a carrier, excipient, or diluent are provided herein. Methods of treating or preventing microbial, fungal and or viral infections and methods of treating diseases and disorders responsive to protein kinase C modulation, topoisomerase I, and/or topoisomerase II modulation are also provided.

Abstract: A mobile training unit including a transportable cargo container having a transport position and at least one training position, the cargo container including: (a) at least one confined working compartment wholly or substantially within the cargo container dimensions; (b) at least one cargo container wall portion movable between a closed transport position and an open training position; (c) at least one door for entry into and exit from the cargo container; and (d) a tower movable between a transport position within the cargo container dimensions, and a training position extending beyond the cargo container. The mobile training unit in its transport position provides a very convenient unit for easy transportation to different locations where training is necessary or desired. This mobile training unit can at least supply facilities to provide training in relation to confined /enclosed spaces, working at height, fall potential and rescue situations.

Abstract: In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about 50 nm to about 500 nm.

Abstract: In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about 50 nm to about 500 nm.

Abstract: In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about 50 nm to about 500 nm.

Abstract: A surgical clip applier is provided including a housing; at least one handle pivotably connected to the housing; a channel assembly extending distally from the housing; a plurality of clips loaded in the clip carrier; a drive channel translatably supported in the housing and the channel assembly, the drive channel being translated upon actuation of the at least one handle; and a counter mechanism supported in the housing, the counter mechanism including indicia visible through the housing, wherein the indicia corresponds to a quantity of clips loaded in the clip applier, wherein the indicia decrements upon each firing of the clip applier resulting in a reduction in the quantity of clips remaining of the plurality of clips.

Abstract: Applicants have discovered a method for the stereoselective and regioselective synthesis of 3?-hydroxy, 3?-methyl-5?-pregnan-20-one (ganaxolone) comprising reacting 5?-pregnane-3,20-dione; with an organometallic methylating agent in an inert solvent to provide a compound of the formula

Abstract: Disclosed are stable corticosteroid nanoparticulate formulations, methods of making and therapeutic uses thereof.

Abstract: In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about 50 nm to about 500 nm.