Abstract: This disclosure is directed to systems and techniques for detecting change in patient health based upon patient data. In one example, a medical system comprising processing circuitry communicably coupled to a glucose sensor and configured to generate continuous glucose sensor measurements of a patient. The processing circuitry is further configured to: extract at least one feature from the continuous glucose sensor measurements over at least one time period, wherein the at least one feature comprises one or more of an amount of time within a pre-determined glucose level range, a number of hypoglycemia events, a number of hyperglycemia events, or one or more statistical metrics corresponding to the continuous glucose sensor measurements; apply a machine learning model to the at least one extracted feature to produce data indicative of a risk of a cardiovascular event; and generate output data based on the risk of the cardiovascular event.

Abstract: There is disclosed an electro-stimulation device having co-operating male/female locking engagement between an internal electrode connector and an externally facing contact electrode. This arrangement aids easy assembly of the electrostimulation device especially when using a unitary device body to form a self-contained device. The device may be arranged to deliver constant target current to a muscle for electro-stimulation of that muscle. The device may be a completely self-contained device with no external means for the adjustment and control of the electro-stimulation delivered to the muscle during treatment.

Abstract: There is disclosed an electro-stimulation device having co-operating male/female locking engagement between an internal electrode connector and an externally facing contact electrode. This arrangement aids easy assembly of the electrostimulation device especially when using a unitary device body to form a self-contained device. The device may be arranged to deliver constant target current to a muscle for electro-stimulation of that muscle. The device may be a completely self-contained device with no external means for the adjustment and control of the electro-stimulation delivered to the muscle during treatment.