Abstract: A novel growth arrest homeobox gene has been discovered and the nucleotide sequences have been determined in both the rat and the human. The expression of the novel homeobox gene inhibits vascular smooth muscle cell growth. The growth arrest homeobox gene hereinafter referred to as the “Gax gene” and its corresponding proteins are useful in the study of vascular smooth muscle cell proliferation and in the treatment of blood vessel diseases that result from excessive smooth muscle cell proliferation, particularly after balloon angioplasty.

Abstract: A novel growth arrest homeobox gene has been discovered and the nucleotide sequences have been determined in both the rat and the human. The expression of the novel homeobox gene inhibits vascular smooth muscle cell growth. The growth arrest homeobox gene hereinafter referred to as the “Gax gene” and its corresponding proteins are useful in the study of vascular smooth muscle cell proliferation and in the treatment of blood vessel diseases that result from excessive smooth muscle cell proliferation, particularly after balloon angioplasty.

Abstract: This invention relates to methods and compositions for modulating endothelial cell viability, endothelial cell migration, and angiogenesis. In particular the invention relates to GSK3 molecules, agents that modify the kinase activity of these molecules, and use of the foregoing in modulating the endothelial cell viability, endothelial cell migration, and angiogenesis.

Abstract: A method of site-specifically delivering a therapeutic agent to a target location within a body cavity, vasculature or tissue. The method comprises the steps of providing a medical device having a substantially saturated solution of therapeutic agent associated therewith; introducing the medical device into the body cavity, vasculature or tissue; releasing a volume of the solution of therapeutic agent from the medical device at the target location at a pressure of from about 0 to about 5 atmospheres for a time of up to about 5 minutes; and withdrawing the medical device from the body cavity, vasculature or tissue. In another aspect, the present invention includes a system for delivering a therapeutic agent to a body cavity, vasculature or tissue, comprising a medical device having a substantially saturated solution of the therapeutic agent associated therewith.

Abstract: A novel growth arrest homeobox gene has been discovered and the nucleotide sequences have been determined in both the rat and the human. The expression of the novel homeobox gene inhibits vascular smooth muscle cell growth. The growth arrest homeobox gene hereinafter referred to as the “Gax gene” and its corresponding proteins are useful in the study of vascular smooth muscle cell proliferation and in the treatment of blood vessel diseases that result from excessive smooth muscle cell proliferation, particularly after balloon angioplasty.

Abstract: Methods and compositions for reducing or preventing the proliferation of vascular smooth muscle cells are provided. The method involves the step of administering an isolated GATA-6 molecule to a subject to prevent or reduce vascular smooth muscle cell proliferation. The isolated GATA-6 molecule can be a GATA-6 nucleic acid or a GATA-6 protein.

Abstract: A method for treating vascular injury, particularly vascular injury resulting from restenosis following angioplasty, and vascular remodeling is provided. The method involves administering to subjects in need of such treatment an effective amount of a Fas ligand molecule.

Abstract: A novel growth arrest homeobox gene has been discovered and the nucleotide sequences have been determined in both the rat and the human. The expression of the novel homeobox gene inhibits vascular smooth muscle cell growth. The growth arrest homeobox gene hereinafter referred to as the "Gax gene" and its corresponding proteins are useful in the study of vascular smooth muscle cell proliferation and in the treatment of blood vessel diseases that result from excessive smooth muscle cell proliferation, particularly after balloon angioplasty.

Abstract: The present invention relates to replication defective recombinant viruses which contain at least one inserted gene encoding all or part of the protein GAX or of a variant of this protein, and to their therapeutic use, in particular for treating post-angioplastic restenosis.

Abstract: A radio frequency (RF) carrier wave is successively divided and the divided parts are non-linearly, phase modulated in response to a modulating signal. The modulating signal is linearized so that the output of the circuit is linear with the modulating signal and then drives differential drivers to control voltage controlled phase shifters in pairs to differentially phase shift the divided RF signals. These phase shifted signals may be efficiently amplified in non-linear, Class C, RF power amplifiers. After amplification the signals are differentially re-combined in an inverse binary tree of hybrid combiners to produce a synthesis output signal. This synthesis output signal is equivalent to the amplitude modulation, and the amplification, of the RF input signal. By operation of the circuit apparatus in accordance with the invention, amplitude modulation at wide bandwidths including hundreds of megahertz may typically be accomplished on microwave RF signals of high power levels including several kilowatts.

Abstract: A series of bits which represent the intensity values of elements of a facsimile picture are preprocessed to eliminate runs of length one, and then applied to a predictive encoder which treats values for alternate pels in two distinct ways. Specifically, the value of every odd pel is predicted, based upon the intensity values of some surrounding picture elements. Each prediction is compared with the true intensity value to yield an error signal. The encoder is also arranged to generate a reference signal which indicates whether the confidence in each prediction for odd pels is high or low. The error values for odd pels within a predefined reordering interval are then sorted or reordered into two groups, dependent upon the reference value. On the other hand, the intensity values of even pels are predicted only when the values cannot be precisely determined from the two previous and subsequent values; the error values for even pels are assembled into a third group.

Abstract: A facsimile signal encoding technique reduces the amount of information needed to represent a picture by (a) generating an error signal (on line 1120) which indicates whether an intensity value prediction corresponds to the true intensity value, (b) generating a reference signal (on line 1005) indicating whether the confidence in each prediction is high or low, (c) reordering the error signal values (logic 1010) into high and low confidence groups in accordance with the reference signal, and (d) assigning code words (encoder 1016) to represent the run lengths of the reordered data. Advantageously, different code dictionaries are selected (line 1019) for code assignment in each of the groups, each dictionary being tailored to the type of runs expected in each group. Also, code words for certain runs may be dropped, and the lengths of other runs may be combined (by logic 1015) before run length coding, again increasing encoder efficiency. A receiver (FIGS. 16-18) for decoding the run lengths is described.

Abstract: The present invention relates to replication defective recombinant viruses which contain at least one inserted gene encoding all or part of the protein GAX or of a variant of this protein, and to their therapeutic use, in particular for treating post-angioplastic restenosis.