Abstract: Elements of drop-stitch material are formed into different structures. In a platform, two legs support a horizontal platform. All are of drop-stitch material, which can be inflated to sufficient pressure for it to be rigid. Valves between the legs and platform allow air to flow between the legs and the platform. Another design is a luggage or cargo carrier for vehicles with a base, top and front walls formed of interconnected drop-stitch material. When the drop-stitch material is inflated, the material forms a cavity which receives luggage or other items. Sidewalls create an enclosed space. elements of the drop-stitch material can form other structures such as a truck shell with openings through the material to acts as windows or a door.

Abstract: The disclosure provides novel methods and compositions for gene editing. In particular, the disclosure relates to compositions and methods of making modified nucleic acid donor templates for highly efficient and precise gene editing.

Abstract: Protecting oligonucleotides are provided. Protecting oligonucleotides with 5? and/or 3? conjugated moieties are provided. Protecting oligonucleotides with chemical modifications are provided. Methods of using the protecting oligonucleotides for genome editing with a CRISPR nuclease and kits for performing the same are also provided.

Abstract: Chemically modified Neisseria meningitidis (Nme) crRNAs, tracrRNAs, and sgRNAs are provided. Methods of using the Nme crRNAs, tracrRNAs, and sgRNAs for genome editing with a Nme CRISPR nuclease and kits for performing the same are also provided.

Abstract: Chemically modified crRNAs and tracrRNAs are provided. crRNAs and tracrRNAs with 5? and/or 3? conjugated moieties are provided. crRNAs and tracrRNAs with modifications in the repeat region of the crRNA or the anti-repeat region of the tracrRNA are provided. Methods of using the crRNAs and tracrRNAs for genome editing with a CRISPR nuclease and kits for performing the same are also provided.

Abstract: Chemically modified crRNAs and tracrRNAs are provided. crRNAs and tracrRNAs with 5? and/or 3? conjugated moieties are provided. crRNAs and tracrRNAs with modifications in the repeat region of the crRNA or the anti-repeat region of the tracrRNA are provided. Methods of using the crRNAs and tracrRNAs for genome editing with a CRISPR nuclease and kits for performing the same are also provided.

Abstract: The disclosure provides novel methods and compositions for gene editing. In particular, the disclosure relates to compositions and methods of making modified nucleic acid donor templates for highly efficient and precise gene editing.

Abstract: Drilling fluids, drilling fluid additives and methods for oil well drilling feature quaternary ammonium salts and act to reduce accretion of bituminous material on metal surfaces of drilling equipment.

Abstract: A wearable sports wallet comprises a lightweight washable band which may be worn around a wrist or ankle during recreational and athletic activities. The band comprises a compartment for receiving and storing small personal items therein and closure means for securing items within the compartment.

Abstract: A removable connector for use between angled, immovable high pressure lines is disclosed. One embodiment of the connector utilizes a tubular elbow portion having a mating flange on each end and an adapter which mates with one of the elbow flanges. The remaining elbow flange mates with a flange at the end of one of the high pressure lines and the free end of the adapter mates with a flange at the end of the other high pressure line. The mating flange surfaces are frusto-conical in shape and corresponding frusto-conical seal rings are placed between the mating surfaces. The elbow and adapter are adapted to have their respective ends placed at the pipe flanges and their bodies rotated toward each other until their opposite ends mate with each other. The flanges are then bolted together and tightened to ensure sealing engagement and bring the elbow and adapter into alignment with the pipes.

Abstract: A method and apparatus for testing through the connector of a circuit card. The apparatus includes a block, which may be tapered, to offset the force applied when engaging the connector. The block is adjustably mounted to accommodate testing of different-sized circuit cards.

Abstract: A method and apparatus for testing through the connector of a circuit card. The apparatus includes a block, which may be tapered, to offset the force applied when engaging the connector. The block is adjustably mounted to accommodate testing of different-sized circuit cards.

Abstract: A removable connector for use between angled, immovable high pressure lines is disclosed. The connector utilizes a tubular elbow portion having a mating flange on each end and an adapter which mates with one of the elbow flanges. The remaining elbow flange mates with a flange at the end of one of the high pressure lines and the free end of the adapter mates with a flange at the end of the other high pressure line. The mating flange surfaces are frusto-conical in shape and corresponding frusto-conical seal rings are placed between the mating surfaces. The elbow and adapter are adapted to have their respective ends placed at the pipe flanges and their bodies rotated toward each other until their opposite ends mate with each other. The flanges are then bolted together and tightened to ensure sealing engagement and bring the elbow and adapter into alignment with the pipes.

Abstract: A tester having as an interconnect structure a pair of resilient, elastomeric, vise-like interconnect grips having conductive tracings thereon. This interconnect structure provides electrical conduction between the conductive tabs of an adapter card under test and the tester.

Abstract: The protective shield for a hypodermic syringe includes a tubular body which overlies the needle of the syringe when the shield is in the forward position. The protective shield has an opening therein to permit exposure of the needle when the shield is in the retracted position. A detent engages the syringe and the shield to limit relative motion therebetween and to releasably lock the shield in its end positions.

Abstract: An electronic telephone network suitable for use with a two-wire telephone line includes a low-output dynamic microphone coupled to a preamplifier. The output signal of the preamplifier is coupled through a first equalization network which is responsive to an equalization signal which is related to the DC line current to equalize the frequency and amplitude spectrum of the transmitted signal irrespective of the telephone line length or loss. The output of the equalization network is applied to a line-driver amplifier, and as a first input to an electronic signal separator or hybrid. The output of the line-driver is coupled to the two-wire line, and as a second input through the separator by way of an attenuator. The output of the separator is coupled to a receive amplifier by way of a second equalization network which is also responsive to the equalization signal to equalize the frequency spectrum of the receive signal as a function of line length.