Patents by Inventor Kenneth Ain

Kenneth Ain has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transcriptional repression of sodium-iodide symporter in thyroid carcinoma
    Patent number: 8252912
    Abstract: The present disclosure relates to a sodium iodide symporter (NIS)-repressor binding site (NRBS) consisting of a DNA molecule spanning from ?645 to ?605 nucleotides (SEQ ID NO:4) or from ?648 to ?620 nucleotides (SEQ ID NO:5) upstream from the translation start site of human NIS gene. The disclosure further relates to a method of restoring iodide transport to a human thyroid carcinoma cell, including: the steps of: i) contacting the cell expressing and forming a NIS repressor protein complex capable of binding to the NRBS of the disclosure with a modulator of said complex, and ii) administering to the cell radiolabeled iodide.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: August 28, 2012
    Assignee: University of Kentucky Research Foundation
    Inventors: Kenneth Ain, Wei Li
  • SODIUM-IODIDE SYMPORTER GENE REPRESSOR BINDING SITE
    Publication number: 20110229408
    Abstract: The present disclosure relates to a sodium iodide symporter (NIS)-repressor binding sites (NRBS) consensus sequence consisting of a DNA molecule having the sequence 5?-T/C(G/A)GCCT(T/C)A(G/A)TTTCCCCA(T/C)CTGT-3?(the “consensus NRBS”). The disclosure further relates to methods of restoring iodide transport in dedifferentiated thyroid cancer cells by interfering with formation or function of the NIS repressor.
    Type: Application
    Filed: March 16, 2010
    Publication date: September 22, 2011
    Inventors: Kenneth AIN, Wei Li
  • HUMAN CONSENSUS SODIUM-IODIDE SYMPORTER REPRESSOR (NIS-REPRESSOR) BINDING SITE
    Publication number: 20110229878
    Abstract: The present disclosure relates to a Sodium-Iodide Symporter-repressor (NIS-repressor) binding site (NRBS) consensus sequence consisting of a DNA molecule having the sequence: 5?-T/C(G/A)GCCT(T/C)A(G/A)TTTCCCCA(T/C)CTGT-3.? The disclosure further relates to methods of screening compounds and other molecules that bind to or inhibits the NIS-repressor or inhibits or interferes with the binding of NIS-repressor to the NIS-repressor binding site.
    Type: Application
    Filed: March 9, 2011
    Publication date: September 22, 2011
    Inventors: Kenneth AIN, Wei Li
  • Transcriptional repression of sodium-iodide symporter in thyroid carcinoma
    Publication number: 20090191584
    Abstract: The present disclosure relates to a sodium iodide symporter (NIS)-repressor binding site (NRBS) consisting of a DNA molecule spanning from ?645 to ?605 nucleotides (SEQ ID NO:4) or from ?648 to ?620 nucleotides (SEQ ID NO:5) upstream from the translation start site of human NIS gene. The disclosure further relates to a method of restoring iodide transport to a human thyroid carcinoma cell, including: the steps of: i) contacting the cell expressing and forming a NIS repressor protein complex capable of binding to the NRBS of the disclosure with a modulator of said complex, and ii) administering to the cell radiolabeled iodide.
    Type: Application
    Filed: April 21, 2008
    Publication date: July 30, 2009
    Inventors: Kenneth Ain, Wei Li