Patents by Inventor Kenneth Anthony

Kenneth Anthony has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250094433
    Abstract: Systems, computer program products, and methods are described herein for combinatorial data outlier detection via database query statement generation. A table comprising rows and columns is received, wherein each column comprises records and a corresponding data element. A datatype to be assigned to each data element is determined, based on each column and using a first machine learning model. Conditions are generated for columns corresponding to each data element. The conditions are combined into a predetermined number of condition combinations, wherein the condition combinations comprise combinatorial sequencing of the conditions. A query statement is generated for each of the condition combinations. The table in queried with each query statement to determine query results. A data element quantity and a record quantity in the query results are determined for each query statement.
    Type: Application
    Filed: September 14, 2023
    Publication date: March 20, 2025
    Applicant: BANK OF AMERICA CORPORATION
    Inventors: Matthew Grant Baber, Dipesh Bhattarai, Andreas Alexander Boeker, Abir Mustafa Chowdhury, Thomas Gorham, Meghan Elise Johansson, Kathryn Wyke Ruse, Mary Ivette Reyes, Kenneth Anthony Smith, II, Bryan Mitchell Wood
  • Patent number: 12103724
    Abstract: A shrink wrapping apparatus, and associated process, includes a housing (turbine) having a wall forming a passage dimensioned to receive the associated container assembly and associated sleeve. The passage has an inlet and an outlet spaced therefrom. A steam/hot air path communicates with the passage to provide steam from an associated steam source to at least a portion of the passage in order to shrink wrap the associated sleeve on the associated container assembly as the container assembly and sleeve move through the passage. The apparatus also includes a stop member for engaging the associated container assembly and holding in the passage for a predetermined amount of time.
    Type: Grant
    Filed: February 14, 2023
    Date of Patent: October 1, 2024
    Inventor: Kenneth Anthony Loritz
  • Patent number: 11976117
    Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: May 7, 2024
    Assignee: McMaster University
    Inventors: Jonathan Lorne Bramson, Christopher W. Helsen, Joanne Alicia Hammill, Kenneth Anthony Mwawasi
  • Patent number: 11970545
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Grant
    Filed: March 22, 2023
    Date of Patent: April 30, 2024
    Assignee: McMaster University
    Inventors: Christopher W. Helsen, Jonathan Bramson, Anna Dvorkin-Gheva, Galina F. Denisova, Ksenia Bezverbnaya, Kenneth Anthony Mwawasi
  • Patent number: 11878035
    Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
    Type: Grant
    Filed: March 22, 2023
    Date of Patent: January 23, 2024
    Assignees: Triumvira Immunologics USA, Inc., McMaster University
    Inventors: Jonathan Lorne Bramson, Christopher W. Helsen, Joanne Alicia Hammill, Kenneth Anthony Mwawasi
  • Publication number: 20230265207
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Application
    Filed: March 22, 2023
    Publication date: August 24, 2023
    Inventors: Christopher W. Helsen, Jonathan Bramson, Anna Dvorkin-Gheva, Galina F. Denisova, Ksenia Bezverbnaya, Kenneth Anthony Mwawasi
  • Publication number: 20230210905
    Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
    Type: Application
    Filed: March 22, 2023
    Publication date: July 6, 2023
    Inventors: Jonathan Lorne Bramson, Christopher W. Helsen, Joanne Alicia Hammill, Kenneth Anthony Mwawasi
  • Publication number: 20230212258
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders anti -gen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Application
    Filed: March 22, 2023
    Publication date: July 6, 2023
    Inventors: Jonathan Bramson, Christopher W. Helsen, Galina Denisova, Rajanish Giri, Kenneth Anthony Mwawasi
  • Publication number: 20230182946
    Abstract: A shrink wrapping apparatus, and associated process, includes a housing (turbine) having a wall forming a passage dimensioned to receive the associated container assembly and associated sleeve. The passage has an inlet and an outlet spaced therefrom. A steam/hot air path communicates with the passage to provide steam from an associated steam source to at least a portion of the passage in order to shrink wrap the associated sleeve on the associated container assembly as the container assembly and sleeve move through the passage. The apparatus also includes a stop member for engaging the associated container assembly and holding in the passage for a predetermined amount of time.
    Type: Application
    Filed: February 14, 2023
    Publication date: June 15, 2023
    Inventor: Kenneth Anthony Loritz
  • Patent number: 11643472
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: May 9, 2023
    Assignee: McMaster University
    Inventors: Christopher W. Helsen, Jonathan Bramson, Anna Dvorkin-Gheva, Galina F. Denisova, Ksenia Bezverbnaya, Kenneth Anthony Mwawasi
  • Patent number: 11629760
    Abstract: A mechanical joint for transferring rotational motion between shafts at an angle and related assemblies. The assemblies can include both fixed and adjustable-angle joint housings for providing high torques in hard to reach areas. Other assemblies include improvements in inboard marine drives that correct the prop angle to generally align with the direction of travel of the boat and outboard marine drives with improved drive trains.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: April 18, 2023
    Assignee: Angle X, Inc.
    Inventor: Kenneth Anthony Lock
  • Patent number: 11603227
    Abstract: A shrink wrapping apparatus, and associated process, includes a housing (turbine) having a wall forming a passage dimensioned to receive the associated container assembly and associated sleeve. The passage has an inlet and an outlet spaced therefrom. A steam/hot air path communicates with the passage to provide steam from an associated steam source to at least a portion of the passage in order to shrink wrap the associated sleeve on the associated container assembly as the container assembly and sleeve move through the passage. The apparatus also includes a stop member for engaging the associated container assembly and holding in the passage for a predetermined amount of time.
    Type: Grant
    Filed: November 18, 2020
    Date of Patent: March 14, 2023
    Inventor: Kenneth Anthony Loritz
  • Patent number: 11548673
    Abstract: A shrink wrapping apparatus, and associated process, includes a housing (turbine) having a wall forming a passage dimensioned to receive the associated container assembly and associated sleeve. The passage has an inlet and an outlet spaced therefrom, and the inlet is located vertically above the outlet such that the associated container assembly and associated sleeve move from the inlet toward the outlet. A steam path communicates with the passage to provide steam from an associated steam source to at least a portion of the passage in order to shrink wrap the associated sleeve on the associated container assembly as the container assembly and sleeve move downwardly through the passage and the steam naturally rises upwardly through the passage.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: January 10, 2023
    Inventor: Kenneth Anthony Loritz
  • Publication number: 20220331364
    Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
    Type: Application
    Filed: June 30, 2022
    Publication date: October 20, 2022
    Inventors: Jonathan Lorne Bramson, Christopher W. Helsen, Joanne Alicia Hammill, Kenneth Anthony Mwawasi
  • Publication number: 20220332790
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders anti-gen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Application
    Filed: June 23, 2022
    Publication date: October 20, 2022
    Inventors: Jonathan Bramson, Christopher W. Helsen, Galina Denisova, Rajanish Giri, Kenneth Anthony Mwawasi
  • Patent number: 11406667
    Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
    Type: Grant
    Filed: August 4, 2021
    Date of Patent: August 9, 2022
    Assignees: Triumvira Immunologies USA, Inc., McMaster University
    Inventors: Jonathan Lorne Bramson, Christopher W. Helsen, Joanne Alicia Hammill, Kenneth Anthony Mwawasi
  • Publication number: 20220153464
    Abstract: A shrink wrapping apparatus, and associated process, includes a housing (turbine) having a wall forming a passage dimensioned to receive the associated container assembly and associated sleeve. The passage has an inlet and an outlet spaced therefrom. A steam/hot air path communicates with the passage to provide steam from an associated steam source to at least a portion of the passage in order to shrink wrap the associated sleeve on the associated container assembly as the container assembly and sleeve move through the passage. The apparatus also includes a stop member for engaging the associated container assembly and holding in the passage for a predetermined amount of time.
    Type: Application
    Filed: November 18, 2020
    Publication date: May 19, 2022
    Inventor: Kenneth Anthony Loritz
  • Patent number: 11261012
    Abstract: A secured storage apparatus includes a sleeve that receives a container/cap assembly therein. The sleeve includes a lock that selectively secures the container/cap assembly and the cap cannot be removed from the container when the assembly is locked in the sleeve. In one arrangement, the cap and sleeve include ribs that prevent rotation of the cap relative to the sleeve. In another arrangement, the container and cap of the assembly freely rotate together in assembled relation within the sleeve, but the cap cannot be rotated relative to the container and/or pushed axially relative to the container.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: March 1, 2022
    Inventor: Kenneth Anthony Loritz
  • Patent number: 11198737
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y177 mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: December 14, 2021
    Assignee: McMaster University
    Inventors: Christopher W. Helsen, Jonathan Bramson, Anna Dvorkin-Gheva, Galina F. Denisova, Ksenia Bezverbnaya, Kenneth Anthony Mwawasi
  • Publication number: 20210369780
    Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
    Type: Application
    Filed: August 4, 2021
    Publication date: December 2, 2021
    Inventors: Jonathan Lorne Bramson, Christopher W. Helsen, Joanne Alicia Hammill, Kenneth Anthony Mwawasi