Abstract: Systems, computer program products, and methods are described herein for combinatorial data outlier detection via database query statement generation. A table comprising rows and columns is received, wherein each column comprises records and a corresponding data element. A datatype to be assigned to each data element is determined, based on each column and using a first machine learning model. Conditions are generated for columns corresponding to each data element. The conditions are combined into a predetermined number of condition combinations, wherein the condition combinations comprise combinatorial sequencing of the conditions. A query statement is generated for each of the condition combinations. The table in queried with each query statement to determine query results. A data element quantity and a record quantity in the query results are determined for each query statement.

Abstract: A shrink wrapping apparatus, and associated process, includes a housing (turbine) having a wall forming a passage dimensioned to receive the associated container assembly and associated sleeve. The passage has an inlet and an outlet spaced therefrom. A steam/hot air path communicates with the passage to provide steam from an associated steam source to at least a portion of the passage in order to shrink wrap the associated sleeve on the associated container assembly as the container assembly and sleeve move through the passage. The apparatus also includes a stop member for engaging the associated container assembly and holding in the passage for a predetermined amount of time.

Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.

Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.

Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.

Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders anti -gen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

Abstract: A shrink wrapping apparatus, and associated process, includes a housing (turbine) having a wall forming a passage dimensioned to receive the associated container assembly and associated sleeve. The passage has an inlet and an outlet spaced therefrom. A steam/hot air path communicates with the passage to provide steam from an associated steam source to at least a portion of the passage in order to shrink wrap the associated sleeve on the associated container assembly as the container assembly and sleeve move through the passage. The apparatus also includes a stop member for engaging the associated container assembly and holding in the passage for a predetermined amount of time.

Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

Abstract: A mechanical joint for transferring rotational motion between shafts at an angle and related assemblies. The assemblies can include both fixed and adjustable-angle joint housings for providing high torques in hard to reach areas. Other assemblies include improvements in inboard marine drives that correct the prop angle to generally align with the direction of travel of the boat and outboard marine drives with improved drive trains.

Abstract: A shrink wrapping apparatus, and associated process, includes a housing (turbine) having a wall forming a passage dimensioned to receive the associated container assembly and associated sleeve. The passage has an inlet and an outlet spaced therefrom. A steam/hot air path communicates with the passage to provide steam from an associated steam source to at least a portion of the passage in order to shrink wrap the associated sleeve on the associated container assembly as the container assembly and sleeve move through the passage. The apparatus also includes a stop member for engaging the associated container assembly and holding in the passage for a predetermined amount of time.

Abstract: A shrink wrapping apparatus, and associated process, includes a housing (turbine) having a wall forming a passage dimensioned to receive the associated container assembly and associated sleeve. The passage has an inlet and an outlet spaced therefrom, and the inlet is located vertically above the outlet such that the associated container assembly and associated sleeve move from the inlet toward the outlet. A steam path communicates with the passage to provide steam from an associated steam source to at least a portion of the passage in order to shrink wrap the associated sleeve on the associated container assembly as the container assembly and sleeve move downwardly through the passage and the steam naturally rises upwardly through the passage.

Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.

Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders anti-gen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.

Abstract: A shrink wrapping apparatus, and associated process, includes a housing (turbine) having a wall forming a passage dimensioned to receive the associated container assembly and associated sleeve. The passage has an inlet and an outlet spaced therefrom. A steam/hot air path communicates with the passage to provide steam from an associated steam source to at least a portion of the passage in order to shrink wrap the associated sleeve on the associated container assembly as the container assembly and sleeve move through the passage. The apparatus also includes a stop member for engaging the associated container assembly and holding in the passage for a predetermined amount of time.

Abstract: A secured storage apparatus includes a sleeve that receives a container/cap assembly therein. The sleeve includes a lock that selectively secures the container/cap assembly and the cap cannot be removed from the container when the assembly is locked in the sleeve. In one arrangement, the cap and sleeve include ribs that prevent rotation of the cap relative to the sleeve. In another arrangement, the container and cap of the assembly freely rotate together in assembled relation within the sleeve, but the cap cannot be rotated relative to the container and/or pushed axially relative to the container.

Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y177 mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.