Patents by Inventor Kenneth B. Marcu

Kenneth B. Marcu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for modulating IKK? activity
    Patent number: 8088915
    Abstract: A method for modulating NF-?B dependent gene transcription in a cell comprised of modulating IKK? protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-?B dependent gene transcription.
    Type: Grant
    Filed: October 13, 2010
    Date of Patent: January 3, 2012
    Assignee: Boehringer Ingelheim Pharmaceuticals Inc.
    Inventors: Jun Li, Xiang Li, Jianfei Yang, Kenneth B. Marcu
  • Biologically active alternative form of the IKK&agr; I&kgr;B kinase
    Patent number: 6803204
    Abstract: The present invention provides isolated I&kgr;B kinases that regulate NF&kgr;B gene transcription that lack both a leucine zipper like &agr;-helix domain and helix-loop-helix domain. Also provided are the amino acid sequences of these kinases and the nucleotide sequence encoding these kinases, and other related protein and nucleic acid molecules.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: October 12, 2004
    Assignee: The Research Foundation of State University of New York
    Inventors: Kenneth B. Marcu, Margery A. Connelly
  • Biologically active alternative form of the IKKalpha IkappaB kinase
    Publication number: 20030073111
    Abstract: The present invention provides isolated I&kgr;B kinases that regulate NF&kgr;B gene transcription that lack both a leucine zipper like &agr;-helix domain and helix-loop-helix domain. Also provided are the amino acid sequences of these kinases and the nucleotide sequence encoding these kinases, and other related protein and nucleic acid molecules.
    Type: Application
    Filed: July 3, 2002
    Publication date: April 17, 2003
    Inventors: Kenneth B. Marcu, Margery A. Connelly
  • Biologically active alternative form of the IKK&agr; I&kgr;B kinase
    Patent number: 6489151
    Abstract: The present invention provides isolated I&kgr;B kinases that regulate NF&kgr;B gene transcription that lack both a leucine zipper like &agr;-helix domain and helix-loop-helix domain. Also provided are the amino acid sequences of these kinases and the nucleotide sequence encoding these kinases, and other related protein and nucleic acid molecules.
    Type: Grant
    Filed: March 27, 2000
    Date of Patent: December 3, 2002
    Assignee: The Research Foundation of State University of New York
    Inventors: Kenneth B. Marcu, Margery A. Connelly
  • Y2H14 an IKK binding protein
    Patent number: 6365722
    Abstract: The present invention provides an isolated I&kgr;B kinase binding protein designated Y2H14 and functional equivalents therof. The amino acid sequence of Y2H14, the nucleotide sequence encoding Y2H14, and other related protein and nucleic acid molecules are also provided.
    Type: Grant
    Filed: November 17, 1998
    Date of Patent: April 2, 2002
    Assignee: The Research of State University of New York
    Inventor: Kenneth B. Marcu
  • Y2H35 a strong IKK binding protein
    Patent number: 6214582
    Abstract: The present invention provides an isolated I&kgr;B kinase binding protein designated Y2H35 and functional equivalents therof. The amino acid sequence of Y2H35, the nucleotide sequence encoding Y2H35, and other related protein and nucleic acid molecules are also provided.
    Type: Grant
    Filed: November 16, 1998
    Date of Patent: April 10, 2001
    Assignee: The Research Foundation of State University of NY
    Inventor: Kenneth B. Marcu
  • Biologically active alternative form of the ikka.alpha. I.kappa.B kinase
    Patent number: 6083732
    Abstract: The present invention provides an isolated I.kappa.B kinase designated IKK.alpha..DELTA.C, that regulates NF.kappa.B gene transcription. IKK.alpha..DELTA.C is an I.kappa.B protein kinase having a kinase domain, a leucine zipper like .alpha.-helix domain, and no helix-loop-helix domain. Also provided are the amino acid sequence of IKK.alpha..DELTA.C, the nucleotide sequence encoding IKK.alpha..DELTA.C, and other related protein and nucleic acid molecules. The invention provides antibodies specific for IKK.alpha..DELTA.C and methods of using the IKK.alpha..DELTA.C proteins of the invention in the development of antiinflammatory agents or immunosuppressants.
    Type: Grant
    Filed: September 25, 1998
    Date of Patent: July 4, 2000
    Assignee: The Research Foundation of the State University of New York
    Inventor: Kenneth B. Marcu
  • Y2H56 A strong IKK binding protein
    Patent number: 6066474
    Abstract: The present invention provides an isolated I.kappa.B kinase binding protein designated Y2H56 and functional equivalents therof. The amino acid sequence of Y2H56, the nucleotide sequence encoding Y2H56, and other related protein and nucleic acid molecules are also provided.
    Type: Grant
    Filed: November 18, 1998
    Date of Patent: May 23, 2000
    Assignee: The Research Foundation of State University of New York
    Inventor: Kenneth B. Marcu
  • Y2H61 an IKK binding protein
    Patent number: 5972655
    Abstract: The present invention provides an isolated I.kappa.B kinase binding protein designated Y2H61 and functional equivalents therof. The amino acid sequence of Y2H61, the nucleotide sequence encoding Y2H61, and other related protein and nucleic acid molecules are also provided.
    Type: Grant
    Filed: November 19, 1998
    Date of Patent: October 26, 1999
    Assignee: The Research Foundation of State University of New York
    Inventor: Kenneth B. Marcu