Patents by Inventor Kenneth B. Walsh

Kenneth B. Walsh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High throughput assay for discovering new inhibitors of the GIRK1/4 channel
    Patent number: 8323911
    Abstract: In certain embodiments of the present disclosure, a method for determining an inhibitor of acetylcholine-activated potassium channel is described. The method includes incubating a cardiac cell in a solution comprising a test compound. The method further includes adding a muscarine (M2) receptor agonist to the cardiac cell in the solution and monitoring the cardiac cell for a change in membrane potential. A statistically insignificant change in the membrane potential following addition of the muscarine (M2) receptor to the solution signifies that the test compound is a K+ channel blocker that inhibits opening of the acetylcholine-activated potassium channel.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: December 4, 2012
    Assignee: University of South Carolina
    Inventor: Kenneth B. Walsh
  • High Throughput Assay for Discovering New Inhibitors of the GIRK1/4 Channel
    Publication number: 20110281278
    Abstract: In certain embodiments of the present disclosure, a method for determining an inhibitor of acetylcholine-activated potassium channel is described. The method includes incubating a cardiac cell in a solution comprising a test compound. The method further includes adding a muscarine (M2) receptor agonist to the cardiac cell in the solution and monitoring the cardiac cell for a change in membrane potential. A statistically insignificant change in the membrane potential following addition of the muscarine (M2) receptor to the solution signifies that the test compound is a K+ channel blocker that inhibits opening of the acetylcholine-activated potassium channel.
    Type: Application
    Filed: May 13, 2011
    Publication date: November 17, 2011
    Applicant: University of South Carolina
    Inventor: Kenneth B. Walsh