Abstract: The present invention provides novel fused bicyclic alkylene linked imidodicarbonimidic diamides. In particular, described herein are N-[2-(indol-3-yl)alkylene]-linked imidodicarbonimidic diamides and N-[2-(pyrrolopyridin-3-yl)alkylene]-linked imidodicarbonimidic diamides (compound of formula (I) or formula (II)), and uses therefor. The compounds of the present invention are believed to be organic cation transporter selective compounds, useful for the treatment of diseases and conditions caused by reduced activity of 5? adenosine monophosphate-activated protein kinase (AMPK).

Abstract: The present invention provides novel fused bicyclic alkylene linked imidodicarbonimidic diamides. In particular, described herein are N-[2-(indol-3-yl)alkylene]-linked imidodicarbonimidic diamides and N-[2-(pyrrolopyridin-3-yl)alkylene]-linked imidodicarbonimidic diamides (compound of formula (I) or formula (II)), and uses therefor. The compounds of the present invention are believed to be organic cation transporter selective compounds, useful for the treatment of diseases and conditions caused by reduced activity of 5? adenosine monophosphate-activated protein kinase (AMPK).

Abstract: The present invention provides novel fused bicyclic alkylene linked imidodicarbonimidic diamides. In particular, described herein are N-[2-(indol-3-yl)alkylene]-linked imidodicarbonimidic diamides and N-[2-(pyrrolopyridin-3-yl)alkylene]-linked imidodicarbonimidic diamides (compound of formula (I) or formula (II)), and uses therefor. The compounds of the present invention are believed to be organic cation transporter selective compounds, useful for the treatment of diseases and conditions caused by reduced activity of 5? adenosine monophosphate-activated protein kinase (AMPK).

Abstract: The present invention provides novel fused bicyclic alkylene linked imidodicarbonimidic diamides. In particular, described herein are N-[2-(indol-3-yl)alkylene]-linked imidodicarbonimidic diamides and N-[2-(pyrrolopyridin-3-yl)alkylene]-linked imidodicarbonimidic diamides (compound of formula (I) or formula (II)), and uses therefor. The compounds of the present invention are believed to be organic cation transporter selective compounds, useful for the treatment of diseases and conditions caused by reduced activity of 5? adenosine monophosphate-activated protein kinase (AMPK).

Abstract: An injector clamp for clamping at least two injectors to an engine head includes a body having at least a first arm and a second arm. Each arm having a first clamping surface and a second clamping surface on opposing sides of the body. A distance between the first clamping surfaces of the first arm and the second arm is different from a distance between the second clamping surfaces of the first arm and the second arm. The body is configurable, for use, in one of: a first position in which the first clamping surfaces from each of the first and second arms can abut with an injector; and a second position in which the second clamping surfaces from each of the first and second arms can abut with an injector.

Abstract: An injector clamp for clamping at least two injectors to an engine head includes a body having at least a first arm and a second arm. Each arm having a first clamping surface and a second clamping surface on opposing sides of the body. A distance between the first clamping surfaces of the first arm and the second arm is different from a distance between the second clamping surfaces of the first arm and the second arm. The body is configurable, for use, in one of: a first position in which the first clamping surfaces from each of the first and second arms can abut with an injector; and a second position in which the second clamping surfaces from each of the first and second arms can abut with an injector.