Abstract: An automatic pool cleaner is provided of the type for random travel over submerged floor and side wall surfaces of a swimming pool or the like to dislodge and collect debris. The pool cleaner includes an electric-powered traction drive system for rotatably driving cleaner wheels, and an electric-powered water management system including a water supply pump and related manifold unit for venturi-vacuuming and collection of settled debris within a porous filter bag. A directional control system including an on-board compass monitors turning movements of the pool cleaner during normal random travel operation, and functions to regulate the traction drive system in a manner to prevent, e.g., excess twisting of a conduit such as a power cable tethered to the pool cleaner.

Abstract: Cloning and characterization of a full length cDNA encoding Sp110 (speckled 110), a novel 110 kDa polypeptide, is disclosed. It is disclosed that Sp110 is a component of the nuclear body, is expressed in leukocytes, and is also expressed in other types of cells, including endothelial cells, smooth muscle cells, liver cells and heart cells, after contact with certain cytokines. The disclosure also includes the following: Sp140 recruits Sp110 to the nuclear body, Sp110 functions as an activator of gene transcription, and Sp110 serves as a nuclear hormone receptor co-activator. Sp110 DNAs, polypeptides, antibodies are disclosed. Also disclosed are Sp110-related screening methods and clinical diagnostic methods.

Abstract: Methods for enhancing the therapeutic or prophylactic effectiveness of an inhaled therapeutic gas are disclosed. The methods include administering to a mammal by inhalation a therapeutically effective amount of gaseous nitric oxide or carbon monoxide, and administering to the mammal a composition containing a compound that sensitizes soluble guanylate cyclase.