Patents by Inventor Kenneth Browne
Kenneth Browne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220073546Abstract: A versatile reagent with a non-nucleotide monomeric unit comprising an enantiomeric center and having a ligand, and first and second coupling groups that are linked to the non-nucleotide monomeric unit. Such a reagent permits preparation of versatile nucleotide/non-nucleotide polymers, having any desired sequence of nucleotide and non-nucleotide monomeric units, each of the latter of which bear a desired ligand. These polymers can, for example, be used as probes which can exhibit enhanced sensitivity and/or which are capable of detecting a genus of nucleotides each species of which has a common target nucleotide sequence of interest bridged by different sequences not of interest.Type: ApplicationFiled: September 27, 2019Publication date: March 10, 2022Applicant: BRENTANO BIOTECHNOLOGY ASSOCIATESInventor: Kenneth A. BROWNE
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Publication number: 20210255180Abstract: Methods, compositions and kits for quantitatively determining specified amounts of 11dhTxB2 in microliter to milliliter quantities of a given sample, wherein, the sample is a biological fluid. Specifically, the biological fluid is a quantity of 1 ml or less of urine from a human subject. The methods may be in the form of consolidated assays that can be run in a high throughput, automation format, such as an enzyme-linked immunosorbent assay (ELISA). Further, the ELISA may be modified into a chemiluminescence assay in order to increase sensitivity and linear range and to reduce the reaction time.Type: ApplicationFiled: June 25, 2019Publication date: August 19, 2021Inventors: Xiaolin Li, Kenneth A. Browne, Ziye Liu
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Publication number: 20180216172Abstract: Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection.Type: ApplicationFiled: December 15, 2017Publication date: August 2, 2018Inventors: Daniel L. Kacian, Kenneth A. Browne
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Patent number: 9856527Abstract: Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection.Type: GrantFiled: May 23, 2016Date of Patent: January 2, 2018Assignee: GEN-PROBE INCORPORATEDInventors: Daniel L. Kacian, Kenneth A. Browne
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Publication number: 20160258009Abstract: Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection.Type: ApplicationFiled: May 23, 2016Publication date: September 8, 2016Inventors: Daniel L. KACIAN, Kenneth A. BROWNE
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Patent number: 9371556Abstract: The present invention relates to reagents for use in deactivating nucleic acids and methods of making and using the same.Type: GrantFiled: March 4, 2005Date of Patent: June 21, 2016Assignee: GEN-PROBE INCORPORATEDInventors: Norman C. Nelson, Kenneth A. Browne, Lizhong Dai, James Russell, Mark E. Filipowsky, Margarita B. Kaminsky, Daniel L. Kacian
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Patent number: 9347098Abstract: Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection.Type: GrantFiled: December 8, 2014Date of Patent: May 24, 2016Assignee: GEN-PROBE INCORPORATEDInventors: Daniel L. Kacian, Kenneth A. Browne
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Publication number: 20150093753Abstract: Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection.Type: ApplicationFiled: December 8, 2014Publication date: April 2, 2015Inventors: Daniel L. Kacian, Kenneth A. Browne
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Patent number: 8932817Abstract: Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection.Type: GrantFiled: October 28, 2013Date of Patent: January 13, 2015Assignee: Gen-Probe IncorporatedInventors: Daniel L. Kacian, Kenneth A. Browne
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Publication number: 20140239223Abstract: The disclosure relates to formulations for use in deactivating nucleic acids and methods of making and using the same.Type: ApplicationFiled: May 2, 2014Publication date: August 28, 2014Applicant: GEN-PROBE INCORPORATEDInventors: Norman C. NELSON, Kenneth A. BROWNE
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Publication number: 20140231710Abstract: The disclosure relates to formulations for use in deactivating nucleic acids and methods of making and using the same.Type: ApplicationFiled: April 24, 2014Publication date: August 21, 2014Applicant: GEN-PROBE INCORPORATEDInventors: Norman C. NELSON, Kenneth A. BROWNE, Lizhong DAI, James RUSSELL, Mark E. FILIPOWSKY, Margarita B. KAMINSKY, Daniel L. KACIAN
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Patent number: 8765652Abstract: The present invention relates to reagents for use in deactivating nucleic acids and methods of making and using the same.Type: GrantFiled: June 25, 2012Date of Patent: July 1, 2014Assignee: Gen-Probe IncorporatedInventors: Norman C. Nelson, Kenneth A. Browne, Lizhong Dai, James Russell, Mark E. Filipowsky, Margarita B. Kaminsky, Daniel L. Kacian
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Publication number: 20140072974Abstract: Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection.Type: ApplicationFiled: October 28, 2013Publication date: March 13, 2014Applicant: Gen-Probe IncorporatedInventors: Daniel L. Kacian, Kenneth A. Browne
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Patent number: 8628924Abstract: Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection.Type: GrantFiled: July 21, 2010Date of Patent: January 14, 2014Assignee: Gen-Probe IncorporatedInventors: Daniel L. Kacian, Kenneth A. Browne
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Publication number: 20130040859Abstract: Hybrid luminescent probes emit light of distinct wavelength ranges and intensities upon energy transfer from an in-common, acridinium ester chemiluminophore to a coupled luminophore. The probes include: (1) a target binding region with a base sequence that is substantially complementary to a portion of the target nucleic acid sequence; (2) an acridinium ester (AE) moiety attached to a first region flanking the target binding region; (3) a luminophore coupled to the AE moiety to allow energy transfer from an acridone moiety, produced by a chemical triggering of the AE moiety, to the luminophore; and (4) a quencher moiety attached to a second region flanking the target binding region, such that the first and second flanking regions are on the opposite sides of the target binding region. The probes are particularly useful in homogeneous assays for sensitive, multiplex quantification of nucleic acid target sequences without prior enzymatic amplification.Type: ApplicationFiled: August 1, 2012Publication date: February 14, 2013Applicant: GEN-PROBE INCORPORATEDInventors: Kenneth A. BROWNE, Ian WEEKS, Richard C. BROWN
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Publication number: 20120260951Abstract: The present invention relates to reagents for use in deactivating nucleic acids and methods of making and using the same.Type: ApplicationFiled: June 25, 2012Publication date: October 18, 2012Applicant: GEN-PROBE INCORPORATEDInventors: Norman C. NELSON, Kenneth A. BROWNE, Lizhong DAI, James RUSSELL, Mark E. FILIPOWSKY, Margarita B. KAMINSKY, Daniel L. KACIAN
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Publication number: 20120231459Abstract: A novel method is disclosed for simultaneous detection and quantification of two or more nucleic acid targets, without need for amplification. The method depends on spectral-temporal resolution of chemiluminescence emitted from independent hybridization-induced chemiluminescent signal (HICS) probes. The utility of this method has been demonstrated by use of resolvable N-linked acridinium and 2,7-dimethoxyacridinium ester labeled probes in a homogeneous assay for sensitive and simultaneous independent quantification of several bacterial and fungal target sequences. Compositions and kits for practicing the method of the present invention are also disclosed.Type: ApplicationFiled: April 12, 2012Publication date: September 13, 2012Applicant: GEN-PROBE INCORPORATEDInventors: Kenneth A. BROWNE, Ian WEEKS
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Publication number: 20110020824Abstract: Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection.Type: ApplicationFiled: July 21, 2010Publication date: January 27, 2011Applicant: Gen-Probe IncorporatedInventors: Daniel L. Kacian, Kenneth A. Browne
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Patent number: 7582470Abstract: Compositions, methods and devices for detecting nucleic acids. The invention particularly regards composite arrays of immobilized amplification primers and hybridization probes. Also disclosed are compositions and methods for covalently immobilizing oligonucleotides and other biological molecules to glass and plastic surfaces.Type: GrantFiled: July 17, 2003Date of Patent: September 1, 2009Assignee: Gen-Probe IncorporatedInventor: Kenneth A. Browne
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Patent number: 7419129Abstract: A lid holding device is composed of an elongate sliding member held within a mounting base. The sliding member travels linearly with respect to the mounting base. The sliding member has a retainer clip. The mounting base has a pair of retainer clips connected to wing sections angling outward from the mounting base. The retainer clips engage the rim of a lid to hold it in place. The sliding member can travel to increase the distance between the retainer clips, thus accommodating a wide range of lid diameters.Type: GrantFiled: March 18, 2004Date of Patent: September 2, 2008Assignee: Jaguar Marketing Services, Inc.Inventor: Kenneth Browne Kixmoeller