Patents by Inventor Kenneth Buechler

Kenneth Buechler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7393647
    Abstract: This invention pertains to methods for detecting B. anthracis and antibodies to B. anthracis, the causative agent of anthrax, in a subject.
    Type: Grant
    Filed: May 27, 2003
    Date of Patent: July 1, 2008
    Assignee: Biosite Incorporated
    Inventors: Gunars Edwin Valkirs, Kenneth Buechler
  • Publication number: 20080124747
    Abstract: This invention pertains to methods for detecting B. anthracis and antibodies to B.
    Type: Application
    Filed: May 27, 2003
    Publication date: May 29, 2008
    Inventors: Gunars Edwin Valkirs, Kenneth Buechler
  • Patent number: 7374888
    Abstract: This invention pertains to methods for detecting B. anthracis and antibodies to B. anthracis, the causative agent of anthrax, in a subject.
    Type: Grant
    Filed: January 8, 2003
    Date of Patent: May 20, 2008
    Assignee: Biosite Incorporated
    Inventors: Gunars Edwin Valkirs, Kenneth Buechler
  • Publication number: 20080050832
    Abstract: The present invention relates to methods and compositions for prognosis in severe immune response syndrome. Values calculated from CCL23, CRP, and NGAL assay measurements are used to indicate the risk of sepsis progression and/or to identify patients at high risk from infections.
    Type: Application
    Filed: March 23, 2007
    Publication date: February 28, 2008
    Inventors: Kenneth Buechler, Joseph Anderberg, Paul McPherson
  • Publication number: 20080008696
    Abstract: The present invention provides methods for the identification and use of diagnostic markers for differential diagnosis of diseases. In various aspects, the invention relates to methods and compositions able to determine the presence or absence of one, and preferably a plurality, of diseases that exhibit one or more similar or identical symptoms. Such methods and compositions can be used to provide assays and assay devices for use in determining the disease underlying one or more non-specific symptoms exhibited in a clinical setting.
    Type: Application
    Filed: April 19, 2007
    Publication date: January 10, 2008
    Inventors: Denis Hochstrasser, Jean-Charles Sanchez, Pierre Lescuyer, Laure Allard, Kenneth Buechler
  • Publication number: 20070269836
    Abstract: The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out venous thromboembolic disease, pulmonary embolism, and/or deep vein thrombosis, and for risk stratification in such conditions.
    Type: Application
    Filed: June 9, 2006
    Publication date: November 22, 2007
    Inventors: Paul McPherson, Kenneth Buechler
  • Publication number: 20070218498
    Abstract: The present invention relates to materials and procedures for evaluating patients suffering from cardiovascular conditions, particularly acute coronary syndromes. In particular, an assay configured to measure the level of soluble FLT-1 in a patient sample, alone or in combination with one or more other markers, provides diagnostic and/or prognostic information. While applicable to diseases and conditions in which inflammation is generally manifested, the methods and compositions described herein are particularly applicable to acute coronary syndromes, including conditions selected from the group consisting of stable angina, unstable angina, non-ST-elevation non-Q wave myocardial infarction, ST-elevation non-Q wave MI, and transmural (Q-wave) MI.
    Type: Application
    Filed: August 29, 2006
    Publication date: September 20, 2007
    Inventors: Kenneth Buechler, Paul McPherson
  • Publication number: 20070196880
    Abstract: A method to facilitate recovery troponin I and/or troponin T from a sample comprising addition of troponin C to the sample or to a surface from which the troponin I and/or troponin T are recovered.
    Type: Application
    Filed: February 9, 2007
    Publication date: August 23, 2007
    Inventors: Kenneth Buechler, Paul McPherson
  • Publication number: 20070154970
    Abstract: The invention relates in part to the use of independent assay controls (IACs) for the optical communication between an assay device and an instrument in monitoring and performing assays, preferably immunoassays.
    Type: Application
    Filed: February 16, 2007
    Publication date: July 5, 2007
    Inventors: Kenneth Buechler, Joseph Anderberg, Paul McPherson
  • Publication number: 20070092911
    Abstract: The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out SIRS, or for differentiating sepsis, severe sepsis, septic shock and/or MODS from each other and/or from non-infectious SIRS.
    Type: Application
    Filed: October 3, 2006
    Publication date: April 26, 2007
    Inventors: Kenneth Buechler, Joseph Anderberg, Paul McPherson
  • Publication number: 20060228748
    Abstract: Water soluble hybrid phthalocyanine derivatives useful in competitive and noncompetitive assays immunoassays, nucleic acid and assays are disclosed and claimed having (1) at least one donor subunit with a desired excitation peak, and (2) at least one acceptor subunit with a desired emission peak, wherein said derivative(s) is/are capable of intramolecular energy transfer from said donor subunit to said acceptor subunit. Such derivatives also may contain an electron transfer subunit. Axial ligands may be covalently bound to the metals contained in the water soluble hybrid phthalocyanine derivatives. Ligands, ligand analogues, polypeptides, proteins and nucleic acids can be linked to the axial ligands of the dyes to form dye conjugates useful in immunoassays and nucleic acid assays.
    Type: Application
    Filed: June 6, 2006
    Publication date: October 12, 2006
    Inventors: Kenneth Buechler, Joseph Noar, Lema Tadesse
  • Publication number: 20060063204
    Abstract: The present invention relates to methods for the diagnosis and evaluation of acute coronary syndromes. In particular, patient test samples are analyzed for the presence and amount of members of a panel of markers comprising one or more specific markers for myocardial injury and one or more non-specific markers for myocardial injury. A variety of markers are disclosed for assembling a panel of markers for such diagnosis and evaluation. In various aspects, the invention provides methods for the early detection and differentiation of stable angina, unstable angina, and myocardial infarction. Invention methods provide rapid, sensitive and specific assays that can greatly increase the number of patients that can receive beneficial treatment and therapy, reduce the costs associated with incorrect diagnosis, and provide important information about the prognosis of the patient.
    Type: Application
    Filed: August 17, 2005
    Publication date: March 23, 2006
    Inventors: Gunars Valkirs, Jeffrey Dahlen, Kenneth Buechler, Howard Kirchick
  • Publication number: 20060051825
    Abstract: The present invention describes compositions and methods designed to determine the presence or amount of BNP or fragments thereof in a sample. In particular, the invention provides materials that may be configured to bind canine BNP in a sandwich assay format. The present invention provides, inter alia, assays designed to rapidly and accurately measure BNP-related species in non-human animals.
    Type: Application
    Filed: September 7, 2005
    Publication date: March 9, 2006
    Inventors: Kenneth Buechler, Joseph Buechler
  • Publication number: 20050282884
    Abstract: The present invention describes carbamic acid ester-derived and valeric acid ester-derived polyfunctional cross-linker molecules, and methods for their synthesis and use. The inclusion of polymeric moieties such as poly(alkylene oxide) in the cross-linkers of the present invention can provide advantageous solubility properties in aqueous environments. Such cross-linkers may be used to form conjugates for use in a variety of assay formats.
    Type: Application
    Filed: July 19, 2005
    Publication date: December 22, 2005
    Inventors: Kenneth Buechler, Mariusz Banaszczyk, Joseph Noar
  • Publication number: 20050255484
    Abstract: The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. A variety of markers are disclosed for assembling a panel for such diagnosis and evaluation. In various aspects, the invention provides methods for early detection and differentiation of stroke types and transient ischemic attacks, for determining the prognosis of a patient presenting with stroke symptoms, and identifying a patient at risk for cerebral vasospasm. Invention methods provide rapid, sensitive and specific assays to greatly increase the number of patients that can receive beneficial stroke treatment and therapy, and reduce the costs associated with incorrect stroke diagnosis.
    Type: Application
    Filed: June 23, 2004
    Publication date: November 17, 2005
    Inventors: Gunars Valkirs, Jeffrey Dahlen, Howard Kirchick, Kenneth Buechler
  • Publication number: 20050181416
    Abstract: The present invention describes carbamic acid ester-derived and valeric acid ester-derived polyfunctional cross-linker molecules, and methods for their synthesis and use. The inclusion of polymeric moieties such as poly(alkylene oxide) in the cross-linkers of the present invention can provide advantageous solubility properties in aqueous environments. Such cross-linkers may be used to form conjugates for use in a variety of assay formats.
    Type: Application
    Filed: March 14, 2005
    Publication date: August 18, 2005
    Inventors: Kenneth Buechler, Mariusz Banaszczyk, Joseph Noar
  • Publication number: 20050164238
    Abstract: The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out SIRS, or for differentiating sepsis, severe sepsis, and/or septic shock from each other and/or from non-infectious SIRS.
    Type: Application
    Filed: September 27, 2004
    Publication date: July 28, 2005
    Inventors: Gunars Valkirs, Jeffrey Dahlen, Howard Kirchick, Kenneth Buechler
  • Publication number: 20050164317
    Abstract: Assay systems and specialized antibodies for the detection and quantitation of troponin I and troponin T in body fluids as an indicator of myocardial infarction. Since troponin I and T exist in various conformations in the blood, the ratios of the monomeric troponin I an T and the binary and ternary complexes, as well as which form of troponin present in the blood, may be related to the metabolic state of the heart. Disclosed is a system to determine the presence of a troponin form or a group of troponin forms in a sample of whole blood, serum or plasma. Disclosed is a stabilized composition of troponin; the stabilized composition can comprise a stabilized composition of troponin I, wherein the troponin I is oxidized, the troponin I can be unbound or the troponin I can be in a complex.
    Type: Application
    Filed: May 21, 2004
    Publication date: July 28, 2005
    Inventors: Kenneth Buechler, Paul McPherson
  • Publication number: 20050148029
    Abstract: The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out SIRS, or for differentiating sepsis, severe sepsis, septic shock and/or MODS from each other and/or from non-infectious SIRS.
    Type: Application
    Filed: December 23, 2004
    Publication date: July 7, 2005
    Inventors: Kenneth Buechler, Joseph Anderberg, Paul McPherson
  • Publication number: 20050147531
    Abstract: Assay device structures for a device where fluid flows from a one region to another. The device structures comprising one or more capillarity-inducing structures; where the capillarity-inducing structure induces capillary force along an axis that is essentially perpendicular to the axis along which capillary force induced in another region of the device.
    Type: Application
    Filed: December 24, 2003
    Publication date: July 7, 2005
    Inventor: Kenneth Buechler