Patents by Inventor Kenneth C. Metchette

Kenneth C. Metchette has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for rendering amplified nucleic acid subsequently unamplifiable
    Patent number: 5221608
    Abstract: Method for treating nucleic acid that is to be amplified such that the nucleic acid is, after amplification, subsequently unamplifiable. Nucleic acid amplification is performed in a reaction containing means in the presence of an isopsoralen. The reaction is thereafter irradiated to render the amplified nucleic acid substantially unamplifiable.
    Type: Grant
    Filed: October 26, 1989
    Date of Patent: June 22, 1993
    Inventors: George D. Cimino, John E. Hearst, Stephen T. Isaacs, Kenneth C. Metchette, John W. Tessman
  • Activation compounds and methods of synthesis of activation compounds
    Patent number: 5139940
    Abstract: The invention is directed to isopsoralen compound compositions that contain a variety of substitutions which yet permit their binding to nucleic acid polymers. Reaction conditions that activate these bound isopsoralens results in covalent crosslinking to the nucleic acid polymers. The resultant complex is inhibited from being a template for the template-directed enzymatic synthesis of a complementary nucleic acid polymer. Beside the isopsoralens compositions, the invention includes their synthesis, the nucleic acid complex production and detection, and the above inhibitory method of use of the isopsoralens.
    Type: Grant
    Filed: October 26, 1989
    Date of Patent: August 18, 1992
    Inventors: Stephen T. Isaacs, Goerge D. Cimino, Kenneth C. Metchette, John W. Tessman