Patents by Inventor Kenneth C. Rupert

Kenneth C. Rupert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetrahydro-benzodiazepinones
    Patent number: 10053431
    Abstract: Disclosed are compounds of Formula I, or pharmaceutically acceptable salts thereof, wherein W, X, Y, Z, R1, R2, R3, R4 and R5 are as described in this application, and methods of using said compounds in the treatment of cancer.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: August 21, 2018
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Shaoqing Chen, Andrew F. Donnell, Robert Francis Kester, Kang Le, Yan Lou, Christophe Michoud, Stacy Remiszewski, Kenneth C. Rupert, Martin Weisel
  • TETRAHYDRO-BENZODIAZEPINONES
    Publication number: 20160272596
    Abstract: Disclosed are compounds of Formula I, or pharmaceutically acceptable salts thereof, wherein W, X, Y, Z, R1, R2, R3, R4 and R5 are as described in this application, and methods of using said compounds in the treatment of cancer.
    Type: Application
    Filed: November 14, 2014
    Publication date: September 22, 2016
    Inventors: Shaoqing Chen, Andrew F. Donnell, Robert Francis Kester, Kang Le, Yan Lou, Christophe Michoud, Stacy Remiszewski, Kenneth C. Rupert, Martin Weisel
  • Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods
    Patent number: 7759356
    Abstract: This invention provides novel arylindenopyridines and arylindenopyrimidines of the formula: wherein R1, R2, R3, R4, and X are as defined above, and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing adenosine A2a receptors. This invention also provides therapeutic and prophylactic methods using the instant compounds and pharmaceutical compositions.
    Type: Grant
    Filed: October 23, 2008
    Date of Patent: July 20, 2010
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Geoffrey R. Heintzelman, James Lawrence Bullington, Kenneth C. Rupert
  • Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods
    Patent number: 7754730
    Abstract: This invention provides novel arylindenopyridines and arylindenopyrimidines of the formula: wherein R1, R2, R3, R4, and X are as defined above, and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing adenosine A2a receptors. This invention also provides therapeutic and prophylactic methods using the instant compounds and pharmaceutical compositions.
    Type: Grant
    Filed: November 16, 2006
    Date of Patent: July 13, 2010
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Geoffrey R. Heintzelman, James Lawrence Bullington, Kenneth C. Rupert
  • ARYLINDENOPYRIDINES AND ARYLINDENOPYRIMIDINES AND RELATED THERAPEUTIC AND PROPHYLACTIC METHODS
    Publication number: 20090054429
    Abstract: This invention provides novel arylindenopyridines and arylindenopyrimidines of the formula: wherein R1, R2, R3, R4, and X are as defined above, and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing adenosine A2a receptors. This invention also provides therapeutic and prophylactic methods using the instant compounds and pharmaceutical compositions.
    Type: Application
    Filed: October 23, 2008
    Publication date: February 26, 2009
    Inventors: Geoffrey R. Heintzelman, James Lawrence Bullington, Kenneth C. Rupert
  • Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods
    Patent number: 7468373
    Abstract: This invention provides novel arylindenopyridines and arylindenopyrimidines of the formula: wherein R1, R2, R3, R4, and X are as defined above, and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing adenosine A2a receptors. This invention also provides therapeutic and prophylactic methods using the instant compounds and pharmaceutical compositions.
    Type: Grant
    Filed: June 29, 2005
    Date of Patent: December 23, 2008
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Geoffrey R. Heintzelman, James Lawrence Bullington, Kenneth C. Rupert
  • Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods
    Patent number: 7345052
    Abstract: This invention provides novel arylindenopyridines and arylindenopyrimidines of the formula: wherein R1, R2, R3, R4, and X are as defined above, and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing adenosine A2a receptors. This invention also provides therapeutic and prophylactic methods using the instant compounds and pharmaceutical compositions.
    Type: Grant
    Filed: June 29, 2005
    Date of Patent: March 18, 2008
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Geoffrey R. Heintzelman, James Lawrence Bullington, Kenneth C. Rupert
  • Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods
    Publication number: 20040127510
    Abstract: This invention provides novel arylindenopyridines and arylindenopyrimidines of the formula: 1
    Type: Application
    Filed: October 3, 2003
    Publication date: July 1, 2004
    Inventors: Geoffrey R. Heintzelman, James Lawrence Bullington, Kenneth C. Rupert
  • Dihydropyridine soft drugs, and related compositions and methods
    Publication number: 20030225120
    Abstract: This invention relates to novel dihydropyridine soft drugs of the formula &PHgr;OOR1, where &PHgr; is a dihydropyridine moiety. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibroncho-constriction activity. Use of such soft drug analogs permits the administration of greater doses of the claimed dihydropyridine compounds without intolerable systemic effects. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders, while avoiding unwanted systemic effects.
    Type: Application
    Filed: March 19, 2003
    Publication date: December 4, 2003
    Inventors: John H. Dodd, James L. Bullington, Daniel A. Hall, James R. Henry, Kenneth C. Rupert
  • Substituted 2-aryl-3-(heteroaryl)-imidazo[1,2-a]pyrimidines, and related pharmaceutical compositions and methods
    Patent number: 6610697
    Abstract: This invention relates to a series of imidazopyrimidines of Formula I, and pharmaceutical compositions containing them. The compounds of the invention inhibit the production of a number of inflammatory cytokines and are useful in the treatment and prevention of diseases associated with the overproduction thereof.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: August 26, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: John H. Dodd, James R. Henry, Kenneth C. Rupert
  • Dihydropyridine soft drugs, and related compositions and methods
    Patent number: 6562824
    Abstract: This invention relates to novel dihydropyridine soft drugs of the formula &PHgr;OOR1, where &PHgr; is a dihydropyridine moiety. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibroncho-constriction activity. Use of such soft drug analogs permits the administration of greater doses of the claimed dihydropyridine compounds without intolerable systemic effects. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasim, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders, while avoiding unwanted systemic effects.
    Type: Grant
    Filed: May 2, 2001
    Date of Patent: May 13, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: John H. Dodd, James L. Bullington, Daniel A. Hall, James R. Henry, Kenneth C. Rupert
  • Oxathiepino[6,5-b]dihydropyridines, and related compositions and methods
    Patent number: 6476022
    Abstract: This invention provides novel oxathiepino[6,5-b]dihydropyridines. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: November 5, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: John H. Dodd, James R. Henry, Kenneth C. Rupert, James L. Bullington, Daniel A. Hall
  • Benzo-fused dithiepino[6,5-b]pyridines, and related compositions and methods
    Patent number: 6472530
    Abstract: This invention provides novel dithiepino[6,5-b]pyridines of the following formulae: These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: October 29, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: John H. Dodd, Kenneth C. Rupert, James L. Bullington, Daniel A. Hall
  • Substituted pyrrolobenzimidazoles for treating inflammatory diseases
    Patent number: 6469174
    Abstract: This invention provides compounds, and pharmaceutically acceptable salts thereof, having the structure shown below, as well as related pharmaceutical compositions, and methods of treatment and synthesis.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: October 22, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: John H. Dodd, James R. Henry, Kenneth C. Rupert
  • Dihydropyridine soft drugs, and related compositions and methods
    Publication number: 20020133018
    Abstract: This invention relates to novel dihydropyridine soft drugs of the formula &PHgr;OOR1, where &PHgr; is a dihydropyridine moiety. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibroncho-constriction activity. Use of such soft drug analogs permits the administration of greater doses of the claimed dihydropyridine compounds without intolerable systemic effects. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasim, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders, while avoiding unwanted systemic effects.
    Type: Application
    Filed: May 2, 2001
    Publication date: September 19, 2002
    Inventors: John H. Dodd, James L. Bullington, Daniel A. Hall, James R. Henry, Kenneth C. Rupert
  • Benzosulfones and related compositions and methods
    Patent number: 6410553
    Abstract: This invention provides novel benzosulfones of the following formulae: These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders.
    Type: Grant
    Filed: December 28, 2000
    Date of Patent: June 25, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: John H. Dodd, Kenneth C. Rupert, James L. Bullington, Daniel A. Hall
  • Benzoether and related compositions and methods
    Patent number: 6410552
    Abstract: This invention provides novel benzoethers of the following formulae: These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders.
    Type: Grant
    Filed: December 28, 2000
    Date of Patent: June 25, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: John H. Dodd, James R. Henry, Kenneth C. Rupert, James L. Bullington, Daniel A. Hall
  • Benzoether and related compositions and methods
    Publication number: 20020049325
    Abstract: This invention provides novel benzoethers of the following formulae: 1
    Type: Application
    Filed: December 28, 2000
    Publication date: April 25, 2002
    Inventors: John H. Dodd, James R. Henry, Kenneth C. Rupert, James L. Bullington, Daniel A. Hall
  • Benzosulfones and related compositions and methods
    Publication number: 20020049326
    Abstract: This invention provides novel benzosulfones of the following formulae: 1
    Type: Application
    Filed: December 28, 2000
    Publication date: April 25, 2002
    Inventors: John H. Dodd, Kenneth C. Rupert, James L. Bullington, Daniel A. Hall
  • Substituted pyrrolobenzimidazoles for treating inflammatory diseases
    Patent number: 6147096
    Abstract: This invention provides compounds, and pharmaceutically acceptable salts thereof, having the structure shown below, as well as related pharmaceutical compositions, and methods of treatment and synthesis.
    Type: Grant
    Filed: February 25, 1999
    Date of Patent: November 14, 2000
    Assignee: Ortho McNeil Pharmaceutical, Inc.
    Inventors: John H. Dodd, James R. Henry, Kenneth C. Rupert