Abstract: This technology relates to a process and associated apparatus for use in spray freeze drying a fluid substance such as fruit juice, pharmaceuticals, nutraceuticals, tea and coffee. The method includes the steps of: holding a chamber at a temperature and pressure below the triple-point of the liquid substance; injecting and/or atomizing the liquid substance into the chamber through at least one injection port to generate a frozen liquid substance portion having a predetermined particle size and a first evaporated liquid substance portion; collecting the FLS portion as a layer on a conveying surface; and exposing the collected layer of FLS portion to a heating means thereby inducing sublimation and generation of a second evaporated liquid substance portion and a product, wherein the conveying surface conveys the collected FLS portion at a rate which achieves substantially a monolayer thickness of the FLS portion to accumulate on the conveying surface.

Abstract: An apparatus and method for mounting a plurality of display monitors is disclosed, wherein the apparatus is provided at a user's desk or workstation. The apparatus can be easily moved toward and away from the user such that all the monitors mounted on the apparatus move in unison in the direction indicated by the user. Accordingly, the apparatus accommodates the visual preferences of virtually all users of the desk or workstation so that eye and skeletal muscle fatigue are reduced.

Abstract: The invention relates to a spray freeze dryer apparatus and method of using same for use in drying or concentrating a raw material which at ambient conditions has a solid and an aqueous portion. The dryer includes a chamber and a chamber pressure reduction device; an inlet nozzle or nozzles through which the raw material is injected into the chamber; and a collection surface or surfaces which collect a frozen portion of the raw material. The chamber is kept at a pressure below the triple-point pressure of the aqueous portion of the raw material. Several additional features are described to control the thickness of the layer on the collection surface.

Abstract: This invention relates to a process and/or method and associated apparatus for use in spray freeze drying a fluid substance such as fruit juice, pharmaceuticals, nutraceuticals, tea and coffee. A fluid substance is sprayed (atomised) and reduces in temperature to below its eutectic temperature; thereby inducing a phase change of fluids in the fluid substance. The atomised fluid substance (AFS) is then subjected to a vacuumous drying chamber in which the AFS is subjected to an energy source to assist sublimation of fluid from the AFS as it is conveyed through the chamber. Such an energy source can provide a temperature gradient through which the AFS passes and is exposed to, all carried out so as to preferably minimise or reduce the likelihood of degradation of the substance being dried (reducing the fluid content).

Abstract: Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed.

Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.

Abstract: Disclosed are CRTH2 inhibitors represented by Structural Formula (I): The values for the variables of Structural Formula (I) are provided herein.

Abstract: An apparatus and method for mounting a plurality of display monitors is disclosed, wherein the apparatus is provided at a user's desk or workstation. The apparatus can be easily moved toward and away from the user such that all the monitors mounted on the apparatus move in unison in the direction indicated by the user. Accordingly, the apparatus accommodates the visual preferences of virtually all users of the desk or workstation so that eye and skeletal muscle fatigue are reduced.

Abstract: The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula I are provided: or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions for the inhibition of Chemokine Receptors and also for the treatment of various diseases, conditions, or disorders, including acute or chronic inflammatory disease, cancer, and osteolytic bone disorders.

Abstract: The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula I are provided: or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions for the inhibition of Chemokine Receptors and also for the treatment of various diseases, conditions, or disorders, including acute or chronic inflammatory disease, cancer or osteolytic bone disorders.

Abstract: Disclosed herein are compounds represented by Structural Formula (I): (I), wherein the variables are defined herein. Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2 (“CRTH2”) for the treatment of inflammatory disorders.

Abstract: The invention provides compounds having the formula: wherein R1 is halogen. The invention also provides compositions comprising the compounds, and methods of treating diseases or disorders that comprise administering one or more of the compounds to a subject in need thereof. The disclosed compounds have CCR1 antagonist activity.

Abstract: The present invention includes compositions and methods for the use of an encapsulation additive having between about 0.1 to about 30 percent isolated and purified vitelline protein B to provide for mixed and extended release formulations.

Abstract: Disclosed herein are compounds represented by Structural Formula (I) and (I-A): Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2, or simply “CRTH2” for the treatment of inflammatory disorders. The variables in Structural Formula (I) and (I-A) are defined herein.

Abstract: The invention relates to compounds having the formula (I). Preferred compounds are antagonists of C—C chemokine receptor 8. The invention also relates to a method for treating a subjected having an inflammatory disorder or viral disorder comprising administering to a subject in need thereof an effective amount of a compound of the invention.

Abstract: A wind screen device for an outdoor grill is provided, which comprises a horizontal bottom plate and a series of vertical side plates. The vertical side plates contact each other and the bottom plate to form an enclosure or windscreen. The enclosure is capable of housing a variety of types and sizes of outdoor cooking units, thereby screening out the wind from the outdoor cooking unit. The rigid plates are hooked together by split rings, which are threaded through slotted holes located near the edges of the plates. The side plates are held in place by angled clips when the windscreen device is assembled. The side plates are also capable of being alternately folded down with all of the plates stacked together for storage. The windscreen device includes an additional opening in one of its side plates, which is designed to admit a gas hose therethrough.

Abstract: Disclosed are novel compounds having the formula or a physiologically acceptable salt, amide, ester or prodrug thereof. The compounds can be used to modulate (antagonize, agonize) chemokine receptor function. Also disclosed is a method for treating a patient having an inflammatory disease and/or viral infection comprising administering an effective amount of a compound of Formula I. In particular embodiments, the invention is a method for treating a patient infected with HIV.

Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof.

Abstract: A mirror door comprising a door with opposed faces, one of which has a recess therein, and a mirror seated within the recess. The mirror has a light reflective front face and a rear face disposed against the door, and is cooperatively dimensioned with the recess to locate its periphery adjacent the periphery of the recess. The mirror is secured in the recess of the door by two adhesives. The first rigid adhesive is disposed between the peripheral portions of the rear face of the mirror and the door recess, and the second adhesive is disposed between the mirror and door inwardly of the peripheral portions. The first adhesive is relatively rigid in comparison to the second adhesive to mount the mirror on the door in a fixed position, and the second adhesive is relatively flexible to accommodate differential expansion between the door and mirror and to dampen impact forces acting between the door and mirror. A method for making a mirror door is also provided.