Patents by Inventor Kenneth Charles Keiler

Kenneth Charles Keiler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IDENTIFICATION OF INHIBITORS OF A BACTERIAL STRESS RESPONSE
    Publication number: 20150361435
    Abstract: A system, a composition, a method and a kit for identifying anti-bacterial agents are provided. The invention described herein is useful in identifying inhibitors of any bacterial stress response. Moreover, the invention can be applied to any sRNA and its target, any transcription factor and its target, and any transcription factor/sRNA pair (i.e., a transcription factor that regulates a sRNA). In particular, the present invention provides a system, a composition, a method and a kit for the identification of cyclic peptides that block the ?E pathway in Escherichia coli.
    Type: Application
    Filed: August 21, 2015
    Publication date: December 17, 2015
    Inventors: Sarah Ellen ADES, Kenneth Charles KEILER
  • IDENTIFICATION OF INHIBITORS OF A BACTERIAL STRESS RESPONSE
    Publication number: 20150141325
    Abstract: A system, a composition, a method and a kit for identifying anti-bacterial agents are provided. The invention described herein is useful in identifying inhibitors of any bacterial stress response. Moreover, the invention can be applied to any sRNA and its target, any transcription factor and its target, and any transcription factor/sRNA pair (i.e., a transcription factor that regulates a sRNA). In particular, the present invention provides a system, a composition, a method and a kit for the identification of cyclic peptides that block the ?E pathway in Escherichia coli.
    Type: Application
    Filed: December 19, 2014
    Publication date: May 21, 2015
    Inventors: Sarah Ellen Ades, Kenneth Charles Keiler
  • F2 derivatives as antibacterial agents
    Patent number: 8975288
    Abstract: A compound or its pharmaceutically acceptable salt, as well as a pharmaceutical, composition containing that compound or salt dissolved or dispersed in a pharmaceutically acceptable carrier, and a method of using that compound or salt in an antibacterial treatment. A contemplated compound corresponds in structure to structural Formula I or a pharmaceutically acceptable salt of that compound, wherein V is O or NR9, Y is halogen, OR10, C1-C4 hydrocarbyl or NHR10, Z is NR2—X—R1 or CH2—R8, n is 1-6, X is H, S(O)2, C(O), C(O)NR7, C(NH)NR7 or C(O)O, and R1, R2, R7, R8, R9 and R10 are defined within.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 10, 2015
    Assignee: The Penn State Research Foundation
    Inventors: Kenneth Charles Keiler, John Nandwa Alumasa
  • Identification of inhibitors of a bacterial stress response
    Patent number: 8962550
    Abstract: A system, a composition, a method and a kit for identifying anti-bacterial agents are provided. The invention described herein is useful in identifying inhibitors of any bacterial stress response. Moreover, the invention can be applied to any sRNA and its target, any transcription factor and its target, and any transcription factor/sRNA pair (i.e., a transcription factor that regulates a sRNA). In particular, the present invention provides a system, a composition, a method and a kit for the identification of cyclic peptides that block the ?E pathway in Escherichia coli.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: February 24, 2015
    Assignee: The Penn State Research Foundation
    Inventors: Sarah Ellen Ades, Kenneth Charles Keiler
  • F2 DERIVATIVES AS ANTIBACTERIAL AGENTS
    Publication number: 20140275192
    Abstract: A compound or its pharmaceutically acceptable salt, as well as a pharmaceutical, composition containing that compound or salt dissolved or dispersed in a pharmaceutically acceptable carrier, and a method of using that compound or salt in an antibacterial treatment. A contemplated compound corresponds in structure to structural Formula I or a pharmaceutically acceptable salt of that compound, wherein V is O or NR9, Y is halogen, OR10, C1-C4 hydrocarbyl or NHR10, Z is NR2—X—R1 or CH2—R8, n is 1-6, X is H, S(O)2, C(O), C(O)NR7, C(NH)NR7 or C(O)O, and R1, R2, R7, R8, R9 and R10 are defined within.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Inventors: Kenneth Charles Keiler, John Nandwa Alumasa
  • Identification of Inhibitors of a Bacterial Stress Response
    Publication number: 20120157375
    Abstract: A system, a composition, a method and a kit for identifying anti-bacterial agents are provided. The invention described herein is useful in identifying inhibitors of any bacterial stress response. Moreover, the invention can be applied to any sRNA and its target, any transcription factor and its target, and any transcription factor/sRNA pair (i.e., a transcription factor that regulates a sRNA). In particular, the present invention provides a system, a composition, a method and a kit for the identification of cyclic peptides that block the ?E pathway in Escherichia coli.
    Type: Application
    Filed: December 16, 2011
    Publication date: June 21, 2012
    Inventors: Sarah Ellen Ades, Kenneth Charles Keiler