Patents by Inventor Kenneth D. Tucker

Kenneth D. Tucker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Autoinducer molecule
    Patent number: 6936447
    Abstract: Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, for Pseudomonas aeruginosa are described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection by Pseudomonas aeruginosa.
    Type: Grant
    Filed: April 3, 2000
    Date of Patent: August 30, 2005
    Assignees: University of Iowa Research Foundation, University of Rochester, Ithaca College
    Inventors: James P. Pearson, Kendall M. Gray, Luciano Passador, Kenneth D. Tucker, Anatol Eberhard, Barbara H. Iglewski, Everett P. Greenberg
  • Substituted 1-benzazepines and derivatives thereof
    Patent number: 6514965
    Abstract: This invention relates to substituted 1-benzazepines and derivatives thereof useful as antibacterial agents, to compositions, including pharmaceutical compositions, comprising such compounds, to processes for making these compounds and to methods of using these compounds for killing bacteria or inhibiting bacterial growth.
    Type: Grant
    Filed: November 7, 2000
    Date of Patent: February 4, 2003
    Assignee: Antex Pharma Inc.
    Inventors: Alenka Tomazic, Liren Huang, Kenneth D. Tucker
  • Autoinducer molecule
    Patent number: 6057288
    Abstract: Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, for Pseudomonas aeruginosa are described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection by Pseudomonas aeruginosa.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: May 2, 2000
    Assignees: University of Iowa, University of Rochester, Ithaca College
    Inventors: James P. Pearson, Kendall M. Gray, Luciano Passador, Kenneth D. Tucker, Anatol Eberhard, Barbara H. Iglewski, Everett P. Greenberg
  • Autoinducer molecule
    Patent number: 5591872
    Abstract: Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, for Pseudomonas aeruginosa are described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection by Pseudomonas aeruginosa.
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: January 7, 1997
    Assignee: The University of Iowa Research Foundation
    Inventors: James P. Pearson, Kendall M. Gray, Luciano Passador, Kenneth D. Tucker, Anatol Eberhard, Barbara H. Iglewski, Everett P. Greenberg
  • Detection, isolation and purification of Clostridium difficile toxin A with toxin receptors
    Patent number: 5098826
    Abstract: A method is provided for detecting the presence of C. difficile toxin A. Stool or other appropriate specimen is contacted with a reagent containing the human X, Y or I-antigens, each of which is a specific receptor for toxin A. The reagent may be intact cells, cell membranes, membrane fractions containing any of these antigens, glycoconjugates, as well as the purified oligosaccharide antigen per se. Binding of toxin A is determined by conventional assay techniques. The method may also be used to isolate and purify toxin A. Conversely, immobilized toxin A may be used to detect, isolate, or purify biological materials of interest expressing the X, Y or I antigens.
    Type: Grant
    Filed: March 9, 1990
    Date of Patent: March 24, 1992
    Assignee: Virginia Tech Intellectual Properties, Inc.
    Inventors: Tracy D. Wilkins, Kenneth D. Tucker