Patents by Inventor Kenneth Darrell Berlin

Kenneth Darrell Berlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHROMAN-SUBSTITUTED, TETRAHYDROQUINOLINE-SUBSTITUTED AND THIOCHROMAN-SUBSTITUTED HETEROAROTINOIDS AS ANTI-CANCER AGENTS
    Publication number: 20210163415
    Abstract: Chemical compounds that inhibit cancer cell growth are provided. The compounds are heteroarotinoids and derivatives thereof with oxygen, nitrogen or sulfur in chroman systems, tetrahydroquinoline systems, and tetrahydrothiochroman systems.
    Type: Application
    Filed: February 4, 2021
    Publication date: June 3, 2021
    Applicant: THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY
    Inventors: KENNETH DARRELL BERLIN, RICHARD A. BUNCE, KRISHNA KUMAR GNANASEKARAN, FIELD M. WATTS, JR., DONGHUA HOWARD ZHOU
  • Chroman-substituted, tetrahydroquinoline-substituted and thiochroman-substituted heteroarotinoids as anti-cancer agents
    Patent number: 10947198
    Abstract: Chemical compounds that inhibit cancer cell growth are provided. The compounds are heteroarotinoids and derivatives thereof with oxygen, nitrogen or sulfur in chroman systems, tetrahydroquinoline systems, and tetrahydrothiochroman systems.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: March 16, 2021
    Assignee: THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY
    Inventors: Kenneth Darrell Berlin, Richard A. Bunce, Krishna Kumar Gnanasekaran, Field M. Watts, Jr., Donghua Howard Zhou
  • CHROMAN-SUBSTITUTED, TETRAHYDROQUINOLINE-SUBSTITUTED AND THIOCHROMAN-SUBSTITUTED HETEROAROTINOIDS AS ANTI-CANCER AGENTS
    Publication number: 20200062711
    Abstract: Chemical compounds that inhibit cancer cell growth are provided. The compounds are heteroarotinoids and derivatives thereof with oxygen, nitrogen or sulfur in chroman systems, tetrahydroquinoline systems, and tetrahydrothiochroman systems.
    Type: Application
    Filed: August 23, 2019
    Publication date: February 27, 2020
    Inventors: KENNETH DARRELL BERLIN, RICHARD A. BUNCE, KRISHNA KUMAR GNANASEKARAN, FIELD M. WATTS, JR., DONGHUA HOWARD ZHOU
  • Heteroarotinoids containing urea or thiourea linker
    Patent number: 6586460
    Abstract: Compounds, known as heteroarotinoids, having varying abilities to inhibit growth of certain cancerous cells, induce normal cell differentiation, and induce apoptosis or death of cancerous cells, of the general formula: in which: Ar and Ar′ denote aryl substituents, and wherein at least one of said aryl substituents comprises an aromatic ring having at least one heteroatom in a fused, partially saturated ring; W denotes O or S; and Q denotes H or i-C3H7.
    Type: Grant
    Filed: April 2, 2001
    Date of Patent: July 1, 2003
    Assignees: The Board of Regents for Oklahoma State University, The Board of Regents for University of Oklahoma
    Inventors: Kenneth Darrell Berlin, Doris M. Benbrook, Eldon C. Nelson
  • N-alkyl and N-acyl derivatives of 3,7-Diazabicyclo-?3.3.1!nonanes and selected salts thereof as multi-class antiarrhythmic agents
    Patent number: 5786481
    Abstract: 3,7-Diazabicyclo?3.3!nonanes and selected derivatives thereof of the general formula: ##STR1## wherein Q=S; Z=CH.sub.2 ; and Y equals an N-acyl or N-alkyl group are disclosed as multiclass antiarrhythmic agents.
    Type: Grant
    Filed: October 19, 1995
    Date of Patent: July 28, 1998
    Assignee: The Board of Regents, Oklahoma State University
    Inventors: Kenneth Darrell Berlin, Gregory Lynn Garrison, Subbiah Sangiah, Cyril Roy Clarke, Chun-Lin Chen, Ralph Lazzara, Benjamin Jacob Scherlag, Eugene Stuart Patterson, George Edward Burrows
  • Azasteroids compounds and derivatives
    Patent number: 3987055
    Abstract: Azasteroids and certain derivatives each of a five ring system containing at least one aromatic nucleus and at least one nitrogen atom. The ring system is fused to a tetrahydrotetralin system or a tetrahydrophenanthrene system. The compounds have solubility in water and disclose antimicrobial, antifertility and potentiate the activity of antibiotics and certain anticancer agents.
    Type: Grant
    Filed: September 11, 1974
    Date of Patent: October 19, 1976
    Assignee: The Board of Regents for the Oklahoma Agricultural & Mechanical Colleges acting for and on behalf of Oklahoma State University of Agriculture and Applied Science
    Inventors: Kenneth Darrell Berlin, Norman Nevill Durham, Claude Desjardins