Patents by Inventor Kenneth DeSilets

Kenneth DeSilets has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7282362
    Abstract: A feeding tray for retaining a liquid nutrient liquid is provided for use with a multiwell filter plate. The feeding tray includes a flat support surface surrounded by walls which retain liquid on the support surface. The flat support surface includes protrusions positioned to contact the membrane portion of a multiplicity of wells of the multiwell filter plate when the multiwell filter plate is removed from the feeding tray. These protrusions remove residual liquids from the bottom of each filter well thereby minimizing cross contamination in subsequent processing steps. Additionally, it may contain one or more baffles, in lieu of or in addition to the protrusions for controlling liquid movement during handling.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: October 16, 2007
    Assignee: Millipore Corporation
    Inventors: Aldo Pitt, Donald Rising, Kenneth DeSilets
  • Patent number: 7166257
    Abstract: A multiwell test apparatus formed of a multiwell filter plate having a plurality of wells and a first feeding plate and a second receiver plate is provided. The wells of the multiwell filter plate each have an open bottom surface to which a membrane is attached, at least one first access hole providing access to the feeding/receiver plate below, a pair of alignment pins designed to fit alignment holes in the feeding/receiver plates in a particular arrangement. The first feeding plate is a single well plate or a multiwell plate used solely for feeding. The second receiver plate is a multiwell plate having the same number of wells as the filter plate and aligned so as to receive the wells of the filter plate therein used as the assaying plate. The use of alignment holes in the feeding/receiver plates and alignment posts in the filter plate ensure precise alignment of the plates when together.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: January 23, 2007
    Assignee: Millipore Corporation
    Inventors: Kenneth DeSilets, Jeanne Phillips, Donald B. Rising
  • Publication number: 20060286003
    Abstract: Multiwell filter comprising a filter plate having a plurality of wells, each including a support. Each well has a corresponding adjacent access port providing access to the corresponding feeding/receiver plate well, e.g. via a pipette. When the filter plate is positioned over a feeding/receiver plate having a plurality of wells, each well of the feeding/receiving plate aligns with and communicates with a corresponding filter plate well. Each access port provides access to a respective well in the feeding/receiver plate, and the wells in the filter plate are not centrally located with respect to the feeding/receiver plate wells, but are shifted in the x and y directions relative to the receiver wells in an amount effective for reducing or eliminating capillary holdup in the gap between the filter wells and the feeding/receiver wells. The wells in the feeding/receiver plate preferably are formed in a U-shaped bottom below each access port.
    Type: Application
    Filed: June 16, 2005
    Publication date: December 21, 2006
    Inventors: Kenneth Desilets, Christopher Scott
  • Patent number: 7148060
    Abstract: A feeding tray for retaining a nutrient medium is provided for use with a multiwell filter plate. The feeding tray includes an inclined support surface surrounded by walls that retain nutrient medium on the support surface. The support surface is inclined away from an area for introducing nutrient medium into the feeding tray toward an area for draining the feeding tray of nutrient medium.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: December 12, 2006
    Assignee: Millipore Corporation
    Inventors: Aldo Pitt, Donald Rising, Kenneth DeSilets
  • Patent number: 7135149
    Abstract: A multiwell test apparatus comprising a multiwell filter plate and having wells that fit within the wells of a single or multiwell receiver plate is provided. The multiwell filter plate also is provided with posts which fit into holes of the receiver plate. The posts and holes are shaped to fix the position of the wells of the multiwell filter plate within the well(s) of the receiver plate and to permit controlled lateral movement of the multiwell filter plate when it is partially removed from the receiver plate so that excess liquid on the wells of the multiwell filter plate can be directed into the well(s) of the receiver plate.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: November 14, 2006
    Assignee: Millipore Corporation
    Inventors: Kenneth DeSilets, Donald Rising
  • Patent number: 7135148
    Abstract: A multiwell filter plate of a multiwell test apparatus is provided to effect addition or removal of liquid from a feeding tray positioned below the multiwell filter tray. Access holes extending through a plate of the multiwell filter plate are provided so that a syringe can be extended through the access holes.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: November 14, 2006
    Assignee: Millipore Corporation
    Inventors: Kenneth DeSilets, Donald Rising, Jeanne Phillips
  • Patent number: 7018588
    Abstract: A multiwell test apparatus formed of a multiwell filter plate having a plurality of wells and a first feeding plate and a second receiver plate is provided. The wells of the multiwell filter plate each have an open bottom surface to which a membrane is attached, at least one first access hole providing access to the feeding/receiver plate below, a pair of alignment pins designed to fit alignment holes in the feeding/receiver plates in a particular arrangement. The first feeding plate is a single well plate or a multiwell plate used solely for feeding. The second receiver plate is a multiwell plate having the same number of wells as the filter plate and aligned so as to receive the wells of the filter plate therein used as the assaying plate. The use of alignment holes in the feeding/receiver plates and alignment posts in the filter plate ensure precise alignment of the plates when together.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: March 28, 2006
    Assignee: Millipore Corporation
    Inventors: Kenneth DeSilets, Jeanne Phillips, Donald B. Rising
  • Publication number: 20050266577
    Abstract: The combination of a supported UF membrane having low non-specific binding (NSB) and high protein retention of the tested chemical entity (CE) in a device that is SBS complaint. The membrane is heat sealed to form one or more integral wells that are used to reduce NSB and improve protein retention and provides a simple, flexible way to reduce CE, such as drug and drug candidate (and other small molecule) NSB so that drug binding studies may more closely predict the behavior of these compounds in vivo.
    Type: Application
    Filed: August 2, 2005
    Publication date: December 1, 2005
    Applicant: Millipore Corporation
    Inventors: John Lynch, Michele Dumon, Alan Weiss, Kenneth Desilets, Stephane Olivier
  • Publication number: 20050236317
    Abstract: The present invention relates to a multiwell filtration plate system formed of a multiwell filter plate, an underdrain, preferably having spouts as the outlet from the underdrain and a collection device such as a collection plate and the use of a mechanical device such as a fixture in the form of a post, a ramp, a rib, a spout protector ring and the like formed in the collection plate wells or on the outside of the underdrain or both for contacting a forming pendant drop formed on the spout of the underdrain and transferring it to the collection plate well.
    Type: Application
    Filed: February 18, 2005
    Publication date: October 27, 2005
    Applicant: Millipore Corporation
    Inventors: Kenneth Desilets, Marc Emerick, Christopher Scott, Steven Sheridan
  • Publication number: 20050163666
    Abstract: A multiwell test apparatus formed of a multiwell filter plate having a plurality of wells and a first feeding plate and a second receiver plate is provided. The wells of the multiwell filter plate each have an open bottom surface to which a membrane is attached, at least one first access hole providing access to the feeding/receiver plate below, a pair of alignment pins designed to fit alignment holes in the feeding/receiver plates in a particular arrangement. The first feeding plate is a single well plate or a multiwell plate used solely for feeding. The second receiver plate is a multiwell plate having the same number of wells as the filter plate and aligned so as to receive the wells of the filter plate therein used as the assaying plate. The use of alignment holes in the feeding/receiver plates and alignment posts in the filter plate ensure precise alignment of the plates when together.
    Type: Application
    Filed: March 17, 2005
    Publication date: July 28, 2005
    Inventors: Kenneth Desilets, Jeanne Phillips, Donald Rising
  • Publication number: 20050095175
    Abstract: Underdrain design for a multiwell device that when fixed to the device (either as an integral or removable component thereof), allows for adequate venting during filtration, minimizes or prevents air lock, and has improved structural integrity. Also disclosed is a laboratory device designed particularly for a multiplate format that includes a plate or tray having a plurality of wells, and an underdrain in fluid communication with each of the plurality of wells. The underdrain can be a separate, removable piece, or can be an integral unitary structure with the plate or tray forming a one-piece design. The design is preferably in compliance with SBS format.
    Type: Application
    Filed: October 8, 2004
    Publication date: May 5, 2005
    Inventors: Kenneth Desilets, Stephane Olivier, Christopher Scott
  • Publication number: 20050051471
    Abstract: The present invention provides an underdrain having an improved spout. The underdrain has particular utility in the construction of both single-well and microarray filtration devices. In a principal embodiment, the underdrain is characterized by its incorporation of a straight-walled, roughly-textured spout, the spout being provided with microhole(s) at a terminal end thereof for the discharge of fluid conducted through the underdrain. An array comprising several of such underdrains can be mated with a corresponding array of wells, with separation material (e.g., membrane material) provided therebetween. The resultant microarray filtration device can be used for conducting several fluid assays contemporaneously with, for example, good “pendant drop” control and low “cross-talk”.
    Type: Application
    Filed: September 4, 2003
    Publication date: March 10, 2005
    Inventors: Joseph Lane, Louis Bonhomme, Douglas Boucher, Richard Burnham, Kenneth Desilets, Luc Lirot, Stephane Olivier, Steven Sheridan
  • Publication number: 20030008387
    Abstract: A feeding tray for retaining a nutrient medium is provided for use with a multiwell filter plate. The feeding tray includes an inclined support surface surrounded by walls that retain nutrient medium on the support surface. The support surface is inclined away from an area for introducing nutrient medium into the feeding tray toward an area for draining the feeding tray of nutrient medium.
    Type: Application
    Filed: June 11, 2002
    Publication date: January 9, 2003
    Applicant: Millipore Corporation
    Inventors: Aldo Pitt, Donald Rising, Kenneth DeSilets
  • Publication number: 20020189374
    Abstract: A multiwell test apparatus formed of a multiwell filter plate having a plurality of wells and a first feeding plate and a second receiver plate is provided. The wells of the multiwell filter plate each have an open bottom surface to which a membrane is attached, at least one first access hole providing access to the feeding/receiver plate below, a pair of alignment pins designed to fit alignment holes in the feeding/receiver plates in a particular arrangement. The first feeding plate is a single well plate or a multiwell plate used solely for feeding. The second receiver plate is a multiwell plate having the same number of wells as the filter plate and aligned so as to receive the wells of the filter plate therein used as the assaying plate. The use of alignment holes in the feeding/receiver plates and alignment posts in the filter plate ensure precise alignment of the plates when together.
    Type: Application
    Filed: June 11, 2002
    Publication date: December 19, 2002
    Inventors: Kenneth DeSilets, Jeanne Phillips, Donald B. Rising
  • Publication number: 20020192119
    Abstract: A multiwell filter plate of a multiwell test apparatus is provided to effect addition or removal of liquid from a feeding tray positioned below the multiwell filter tray. Access holes extending through a plate of the multiwell filter plate are provided so that a syringe can be extended through the access holes.
    Type: Application
    Filed: June 11, 2002
    Publication date: December 19, 2002
    Inventors: Kenneth DeSilets, Donald Rising, Jeanne Phillips
  • Publication number: 20020192811
    Abstract: A feeding tray for retaining a liquid nutrient liquid is provided for use with a multiwell filter plate. The feeding tray includes a flat support surface surrounded by walls which retain liquid on the support surface. The flat support surface includes protrusions positioned to contact the membrane portion of a multiplicity of wells of the multiwell filter plate when the multiwell filter plate is removed from the feeding tray. These protrusions remove residual liquids from the bottom of each filter well thereby minimizing cross contamination in subsequent processing steps. Additionally, it may contain one or more baffles, in lieu of or in addition to the protrusions for controlling liquid movement during handling.
    Type: Application
    Filed: June 11, 2002
    Publication date: December 19, 2002
    Applicant: Millipore Corporation
    Inventors: Aldo Pitt, Donald Rising, Kenneth DeSilets
  • Publication number: 20020192120
    Abstract: A multiwell test apparatus comprising a multiwell filter plate and having wells that fit within the wells of a single or multiwell receiver plate is provided. The multiwell filter plate also is provided with posts which fit into holes of the receiver plate. The posts and holes are shaped to fix the position of the wells of the multiwell filter plate within the well(s) of the receiver plate and to permit controlled lateral movement of the multiwell filter plate when it is partially removed from the receiver plate so that excess liquid on the wells of the multiwell filter plate can be directed into the well(s) of the receiver plate.
    Type: Application
    Filed: June 11, 2002
    Publication date: December 19, 2002
    Inventors: Kenneth DeSilets, Donald Rising