Patents by Inventor Kenneth E. Bernstein

Kenneth E. Bernstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR TREATMENT OF ALZHEIMER'S DISEASE
    Publication number: 20130295062
    Abstract: The present invention relates to methods and compositions for use in the treatment of neurological disorders, such as Alzheimer's disease and dementia. In one embodiment, the present invention provides a method of treatment of Alzheimer's disease in an individual by administering a composition overexpressing ACE to the individual. In another embodiment, the method of treatment comprises administering a composition comprising a therapeutically effective dosage of ACE.
    Type: Application
    Filed: January 18, 2012
    Publication date: November 7, 2013
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Kenneth E. Bernstein, Maya Koronyo, Sebastien Fuchs, Yosef Koronyo
  • USE OF ANGIOTENSIN CONVERTING ENZYME (ACE) DOMAIN SPECIFIC INHIBITORS TO INHIBIT OR ENHANCE CYTOKINE PRODUCTION AND ALTER IMMUNE RESPONSE
    Publication number: 20120088730
    Abstract: The present invention relates to the discovery that the two ACE domains can have very different effects on cytokine expression. In one embodiment, the present invention provides a method of regulating and/or treating a condition in a subject by administering a therapeutically effective dosage of site specific ACE inhibitor. In another embodiment, the condition is inflammation and/or immune response.
    Type: Application
    Filed: June 2, 2010
    Publication date: April 12, 2012
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Kenneth E. Bernstein, Chentao Lin
  • METHODS OF TREATMENT FOR PULMONARY FIBROSIS
    Publication number: 20110104175
    Abstract: The invention relates to compositions and methods for treating fibrosing lung diseases, reducing pulmonary cytokine production in animals, treating bleomycin induced lung disease and treating cancer. Specifically, the present subject matter incorporates inactivation of the N-terminal site of an angiotensin-converting enzyme and/or administration of AcSDKP.
    Type: Application
    Filed: June 3, 2009
    Publication date: May 5, 2011
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Kenneth E. Bernstein, Sebastien Fuchs
  • SELF-INDUCED DELETION OF DNA
    Publication number: 20080295192
    Abstract: The present invention is directed to a method for deleting DNA sequences in a tissue specific manner. In one embodiment, DNA sequences are specifically deleted in germline tissue. In a second embodiment, DNA sequences are specifically deleted in desired somatic tissue. The present invention is further directed to a nucleic acid molecule for use in the method. More specifically, a nucleic acid molecule is provide by the present invention which comprises (a) a recombinase site, (b) a tissue-specific promoter, (c) a recombinase gene, (d) a foreign DNA, and (e) a recombinase site. The nucleic acid molecule may further comprise a gene which is desired to be incorporated into and expressed in a transgenic organism. The method can be used in both plants and animals, and has many applications as described herein.
    Type: Application
    Filed: June 7, 2007
    Publication date: November 27, 2008
    Applicant: UNIVERSITY OF UTAH
    Inventors: Kirk R. Thomas, Kenneth E. Bernstein, Michaeline Bunting, Joy Greer, Mario Capecchi