Patents by Inventor Kenneth E. Palmer

Kenneth E. Palmer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220289798
    Abstract: Provided herein are GRFT variants and methods of using such GRFT variants. The GRFT variants described herein can be PEGylated, which significantly improves the pharmacokinetics and decreases the immunogenicity of the GFRT composition.
    Type: Application
    Filed: September 10, 2020
    Publication date: September 15, 2022
    Applicants: University of Louisville Research Foundation, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Joshua Fuqua, Krystal Hamorsky, Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer
  • Patent number: 11339195
    Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: May 24, 2022
    Inventors: Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer, Lisa C. Rohan, Joshua L. Fuqua, Lindsay F. Kramzer
  • Publication number: 20210299156
    Abstract: A method of administering an anti-nucleolin agent to a patient by delivering the anti-nucleolin agent to the mouth, lungs, throat, nose and eyes of a patient to prevent COVID-19. Compositions for administering an anti-nucleolin agent comprising a container and a formulation including an anti-nucleolin agent. The anti-nucleolin agent may be administered via an inhaler, nasal spray or eye drop.
    Type: Application
    Filed: March 29, 2021
    Publication date: September 30, 2021
    Applicant: Qualigen Inc.
    Inventors: Paula J. Bates, Kenneth E. Palmer, Wajdi Abdul-Ahad, Michael Poirier
  • Publication number: 20200087359
    Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.
    Type: Application
    Filed: November 27, 2019
    Publication date: March 19, 2020
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, University of Louisville Research Foundation, Inc., University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer, Lisa C. Rohan, Joshua L. Fuqua, Lindsay F. Kramzer
  • Patent number: 10501507
    Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: December 10, 2019
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, University of Louisville Research Foundation, Inc., University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer, Lisa C. Rohan, Joshua L. Fuqua, Lindsay F. Kramzer
  • Publication number: 20180016307
    Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.
    Type: Application
    Filed: February 10, 2016
    Publication date: January 18, 2018
    Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Serv, University of Louisville Research Foundation, Inc., University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer, Lisa C. Rohan, Joshua L. Fuqua, Lindsay F. Kramzer
  • Publication number: 20160175426
    Abstract: Polypeptides, compositions, and methods for treatment of papillomavirus (PV) infections including a papillomavirus (PV) minor capsid (L2) polypeptide fragment and a cholera toxin B subunit (CTB) polypeptide are described. Polypeptides and compositions disclosed herein can be administered to the mucosa of a subject, resulting in unexpectedly beneficial production of cross-neutralizing antibodies.
    Type: Application
    Filed: July 16, 2014
    Publication date: June 23, 2016
    Inventors: Kenneth E. Palmer, Nobuyuki Matoba, Joshua Fuqua
  • Patent number: 7939318
    Abstract: Herein-described are various methods for making a vaccine that are made of re-assembled virus like particles (VLP). First, the VLPs are disassembled into encapsidation intermediate populations. Each encapsidation intermediate population undergoes, for instance, chemical conjugation of unique peptide or nucleic moieties to form separate populations. Thereafter, a predetermined amount of each of the several (one or more) different encapsidation intermediates from the different populations is mixed and joined, forming intact VLPs, surrounding a nucleic acid core, that are composed of different encapsidation intermediate such that the reassembled VLP displays more than one peptide or nucleic acid. The nucleic acid can function either as a scaffold alone or can be engineered for the expression of an immunomodulatory protein in a eukaryotic cell.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: May 10, 2011
    Assignee: Kentucky Bioprocessing, LLC
    Inventors: Alison A. McCormick, Mark L. Smith, Kenneth E. Palmer, John A. Lindbo, Long V. Nguyen, Gregory P. Pogue
  • Publication number: 20090208522
    Abstract: The invention provides a fusion protein comprising a plant virus coat protein and a GDF8 peptide domain, or antigenic fragment of the GDF8 peptide domain. Plant virus vectors expressing the fusion protein and methods of using these vectors are also provided.
    Type: Application
    Filed: August 22, 2008
    Publication date: August 20, 2009
    Inventors: David E. Junker, Mark D. Cochran, Mark L. Smith, Kenneth E. Palmer, Gregory P. Pogue
  • Publication number: 20090053261
    Abstract: Display of peptides or proteins in an ordered, repetitive array, such as on the surface of a virus-like particle, is known to induce an enhanced immune response relative to vaccination with the “free” protein antigen. The 2100 coat proteins comprising the rod-shaped capsid of Tobacco mosaic virus (TMV) can accommodate short peptide insertions into the primary sequence, but the display of larger protein moieties on the virion surface by genetic fusions to the capsid protein has not been possible. Since TMV lacks surface exposed residues compatible with commonly available linker chemistries, we employed a randomized library approach to introduce a reactive lysine at the externally located at the amino-terminus of the coat protein. We found that we could easily control the extent of virion conjugation and demonstrated stoichiometric biotinylation of the introduced lysine.
    Type: Application
    Filed: September 8, 2006
    Publication date: February 26, 2009
    Inventors: John A. Lindbo, Kenneth E. Palmer, Mark L. Smith
  • Patent number: 7432079
    Abstract: The invention provides a fusion protein comprising a plant virus coat protein and a GDF8 peptide domain, or antigenic fragment of the GDF8 peptide domain. Plant virus vectors expressing the fusion protein and methods of using these vectors are also provided.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: October 7, 2008
    Assignee: Schering-Plough Animal Health Corporation
    Inventors: David E. Junker, Mark D. Cochran, Mark L. Smith, Kenneth E. Palmer, Gregory P. Pogue
  • Publication number: 20080213293
    Abstract: Juvenile-onset recurrent respiratory papillomatosis is treated using active vaccination or passive immune therapy of neutralizing antibodies against HPV L2 neutralizing epitopes.
    Type: Application
    Filed: December 4, 2007
    Publication date: September 4, 2008
    Applicant: LARGE SCALE BIOLOGY CORPORATION
    Inventors: Kenneth E. Palmer, Daniel Tuse, Stephen J. Reinl, Mark L. Smith, Gregory P. Pogue
  • Patent number: 7049134
    Abstract: A rolling circle DNA replicon which replicates in a host eukaryotic cell is disclosed which has a truncated replication cycle. The rolling circle DNA replicon comprises the following elements present on the same DNA molecule. It contains a Rep gene open reading frame from a virus belonging to the viral taxonomic families Geminiviridae, Circoviridae or genus Nanovirus. The Rep gene open reading frame is placed under transcriptional control of a promoter, which is placed 5? of the gene. Any sequences that are required to be present in cis on the rolling circle DNA replicon in order that the Rep protein might promote replication of the rolling circle DNA replicon are included. An expression cassette for expression of an ancillary protein that is capable of creating a cellular environment permissive for replication of the rolling circle DNA replicon in the host cell of interest is also included.
    Type: Grant
    Filed: November 1, 2002
    Date of Patent: May 23, 2006
    Assignee: Large Scale Biology Corporation
    Inventors: Kenneth E. Palmer, Gregory P. Pogue
  • Publication number: 20040253687
    Abstract: A plurality of proteins of interest, or peptides of interest, or other genetically expressed materials, are screened and subsequently produced using any of a variety of expression systems. The plurality of proteins are extracted from a plurality of separate, processed green juices, each green juice containing one of the proteins of interest. A multi-channel apparatus processes the various green juices, one green juice per channel. The apparatus is computer controlled such that the various valves in each channel and pump are controlled in an automated manner to extract each protein of interest and deliver each protein of interest into its own storage vessel.
    Type: Application
    Filed: June 29, 2004
    Publication date: December 16, 2004
    Inventors: Mark L. Smith, Kenneth E. Palmer, Gregory P. Pogue, John A. Lindbo, Kathleen M. Hanley, David P. Mannion, Gershon M. Wolfe
  • Publication number: 20040170606
    Abstract: Vaccines and diagnostic composition are made and used for preventing, treating and detecting antigens from a papilloma virus, ebola virus, HIV virus, Rift Valley Fever virus or a parvovirus. The epitopes of these viruses are produced as genetically engineered fusion peptides in plants by infection with a recombinant tobamovirus vectors to express fusion proteins containing the epitope peptides.
    Type: Application
    Filed: September 3, 2003
    Publication date: September 2, 2004
    Inventors: Kenneth E. Palmer, Long V. Nguyen, Rachel L. Toth, Michael Jones, Sean Chapman, Lisa Smolenska, Alison A. McCormick, Gregory P. Pogue
  • Publication number: 20040033585
    Abstract: Herein described are various methods for making a vaccine that are made of re-assembled virus like particles (VLP). First, the VLPs are disassembled into encapsidation intermediate populations. Each encapsidation intermediate population undergoes, for instance, chemical conjugation of unique peptide or nucleic moieties to form separate populations. Thereafter, a predetermined amount of each of the several (one or more) different encapsidation intermediates from the different populations is mixed and joined, forming intact VLPs, surrounding a nucleic acid core, that are composed of different encapsidation intermediate such that the reassembled VLP displays more than one peptide or nucleic acid. The nucleic acid can function either as a scaffold alone or can be engineered for the expression of an immunomodulatory protein in a eukaryotic cell.
    Type: Application
    Filed: June 6, 2003
    Publication date: February 19, 2004
    Inventors: Alison A. McCormick, Mark L. Smith, Kenneth E. Palmer, John A. Lindbo, Long V. Nguyen, Gregory P. Pogue
  • Publication number: 20030143741
    Abstract: A rolling circle DNA replicon which replicates in a host eukaryotic cell is disclosed which has a truncated replication cycle. The rolling circle DNA replicon comprises the following elements present on the same DNA molecule. It contains a Rep gene open reading frame from a virus belonging to the viral taxonomic families Geminiviridae, Circoviridae or genus Nanovirus. The Rep gene open reading frame is placed under transcriptional control of a promoter, which is placed 5′ of the gene. Any sequences that are required to be present in cis on the rolling circle DNA replicon in order that the Rep protein might promote replication of the rolling circle DNA replicon are included. An expression cassette for expression of an ancillary protein that is capable of creating a cellular environment permissive for replication of the rolling circle DNA replicon in the host cell of interest is also included.
    Type: Application
    Filed: November 1, 2002
    Publication date: July 31, 2003
    Applicant: Large Scale Biology Corporation
    Inventors: Kenneth E. Palmer, Gregory P. Pogue
  • Publication number: 20030104571
    Abstract: A plurality of proteins of interest, or peptides of interest, or other genetically expressed materials, are screened and subsequently produced using any of a variety of expression systems. The plurality of proteins are extracted from a plurality of separate, processed green juices, each green juice containing one of the proteins of interest. A multi-channel apparatus processes the various green juices, one green juice per channel. The apparatus is computer controlled such that the various valves in each channel and pump are controlled in an automated manner to extract each protein of interest and deliver each protein of interest into its own storage vessel.
    Type: Application
    Filed: December 4, 2002
    Publication date: June 5, 2003
    Inventors: Mark L. Smith, Kenneth E. Palmer, Gregory P. Pogue, John A. Lindbo, Kathleen M. Hanley, David P. Mannion, Gershon M. Wolfe
  • Publication number: 20030079248
    Abstract: A gene amplification system based on plant viral genetic elements dramatically increases foreign protein production in plants. A safer and more economical production system for vaccines and antibodies in recombinant plants grown using agricultural practice is described. The high-level expression system uses the replicative process of a plant mastrevirus, exemplified by bean yellow dwarf virus (BeYDV). The expression system is preferably inducible to avoid interference with plant growth and development. Developmental cues, such as fruit ripening, are employed to trigger expression of the foreign protein using a tissue-specific promoter. A single, stably integrated expression cassette for foreign protein is replicated extrachromosomally in ripening fruit, forming hundreds of transcriptionally competent copies. Preferred plant hosts include tomato as a model system and soybean for production of large quantities of protein at high total protein levels.
    Type: Application
    Filed: May 20, 2002
    Publication date: April 24, 2003
    Inventors: Hugh Mason, Kenneth E. Palmer, Kathleen L. Hefferon, Tsafrir S. Mor, Charles Arntzen
  • Publication number: 20020187952
    Abstract: A rolling circle DNA replicon which replicates in a host eukaryotic cell and is capable of eliciting an immunization reaction is disclosed. The rolling circle DNA replicon comprises a Rep gene open reading frame placed under transcriptional control of a promoter, which is placed 5′ of the gene. Any sequences that are required to be present in cis on the rolling circle DNA replicon in order that the Rep protein might promote replication of the rolling circle DNA replicon and elicit an immunization reaction are included. At least one expression cassette with an RNA polymerase II promoter, a multiple cloning site, and transcription termination and polyadenylation signals suitable for transcription of RNA molecules not normally intrinsic to a geminiviral, circoviral or nanoviral genome is also included.
    Type: Application
    Filed: December 20, 2001
    Publication date: December 12, 2002
    Inventors: Kenneth E. Palmer, Gregory G. Pogue, Alison McCormick