Patents by Inventor Kenneth E. Stockman
Kenneth E. Stockman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11826485Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.Type: GrantFiled: April 23, 2021Date of Patent: November 28, 2023Assignee: HyperBranch Medical Technology, Inc.Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
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Publication number: 20220234993Abstract: Provided is a method of making ethylenediaminetetraacetic acid (EDTA) comprising the steps: (a) providing a reaction mixture (a) comprising ethylenediamine (EDA) and glycolonitrile (GN), wherein reaction mixture (a) comprises 0% to 0.1% by weight, based on the weight of reaction mixture (a), of any base having pKa of the conjugate acid (PKaH) of 13 or higher; (b) causing or allowing reaction mixture (a) to react to form a dinitrile (DN) compound; (c) bringing the DN into contact with aqueous solution of a base having pKaH of 11 or higher, and causing or allowing the resulting mixture to react to form a diacid compound (DA); (d) causing or allowing the DA to react, either sequentially or simultaneously, with additional GN to form products (Pd); (e) causing or allowing products (Pd) to react with a base having pKaH of 11 or higher, to form EDTA.Type: ApplicationFiled: June 3, 2020Publication date: July 28, 2022Inventors: Deboleena Chakraborty, Edward D. Daugs, Kenneth E. Stockman, Ronald Peterson
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Publication number: 20210275718Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.Type: ApplicationFiled: April 23, 2021Publication date: September 9, 2021Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
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Patent number: 11027043Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.Type: GrantFiled: June 5, 2020Date of Patent: June 8, 2021Assignee: HyperBranch Medical Technology, Inc.Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
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Patent number: 10688216Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.Type: GrantFiled: January 29, 2018Date of Patent: June 23, 2020Assignee: HyperBranch Medical Technology, Inc.Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
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Patent number: 10550083Abstract: 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction that are conducted as a single pot process. 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement.Type: GrantFiled: January 23, 2017Date of Patent: February 4, 2020Assignee: Dow AgroSciences LLCInventors: Kenneth E. Stockman, Gregory T. Whiteker, Erich J. Molitor, Nakyen Choy
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Publication number: 20190112271Abstract: 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction that are conducted as a single pot process. 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement.Type: ApplicationFiled: January 23, 2017Publication date: April 18, 2019Inventors: Kenneth E. STOCKMAN, Gregory T. WHITEKER, Erich J. MOLITOR, Nakyen CHOY
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Publication number: 20190001018Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.Type: ApplicationFiled: January 29, 2018Publication date: January 3, 2019Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
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Patent number: 9878066Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.Type: GrantFiled: July 18, 2016Date of Patent: January 30, 2018Assignee: HYPERBRANCH MEDICAL TECHNOLOGY, INC.Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
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Publication number: 20170305831Abstract: The present invention is a process for preparing a hydroxyalkyl sorbate comprising the steps of of: a) contacting together in a reaction vessel a solvent, sorbic acid, a transition metal halide catalyst, an anti-oxidant, and an alkylene oxide under conditions sufficient to form the hydroxyalkyl sorbate; b) removing the solvent in vacuo, wherein the anti-oxidant is characterized by the following formula or a carboxylic acid salt thereof: wherein Y, x, and R1 are defined herein. The process of the present invention provides a convenient way of preparing hydroxyalkyl sorbates in high yield and purity without complicated workup steps.Type: ApplicationFiled: October 22, 2014Publication date: October 26, 2017Inventors: Selvanathan Arumugam, John Ell, Bo Lu, Brandon Rowe, Kenneth E. Stockman, Jiguang Zhang
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Patent number: 9718783Abstract: 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement. 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction.Type: GrantFiled: October 31, 2016Date of Patent: August 1, 2017Assignee: Dow AgroSciences LLCInventors: James M. Renga, Yuanming Zhu, Gregory T. Whiteker, Nakyen Choy, Kenneth E. Stockman
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Publication number: 20170049924Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.Type: ApplicationFiled: July 18, 2016Publication date: February 23, 2017Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
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Publication number: 20170044105Abstract: 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement. 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction.Type: ApplicationFiled: October 31, 2016Publication date: February 16, 2017Inventors: James M. Renga, Yuanming Zhu, Gregory T. Whiteker, Nakyen Choy, Kenneth E. Stockman
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Patent number: 9481651Abstract: 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement. 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction.Type: GrantFiled: July 8, 2015Date of Patent: November 1, 2016Assignee: Dow AgroSciences LLCInventors: James M. Renga, Yuanming Zhu, Gregory T. Whiteker, Nakyen Choy, Kenneth E. Stockman
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Publication number: 20160248020Abstract: The invention provides a composition comprising at least one fluorene substituted triazine derived compound of Formula 1, as described herein, and electronic devices containing the same. Such devices have improved efficiency and better driving voltage.Type: ApplicationFiled: November 10, 2014Publication date: August 25, 2016Inventors: Mark E. Ondari, Kyoung Moo Koh, Dean M. Welsh, Tomas D. Paine, Liang Hong, Kenneth E. Stockman, Hong-Yeop Na, Kyung-Joo Lee
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Patent number: 9393344Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.Type: GrantFiled: January 11, 2007Date of Patent: July 19, 2016Assignee: HyperBranch Medical Technology, Inc.Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
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Publication number: 20160009650Abstract: 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement. 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction.Type: ApplicationFiled: July 8, 2015Publication date: January 14, 2016Inventors: James M. Renga, Yuanming Zhu, Gregory T. Whiteker, Nakyen Choy, Kenneth E. Stockman
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Publication number: 20100069927Abstract: One aspect of the present invention generally relates to methods of sealing a defect, wound or void using a two component system composed of masking material, which creates an anti-adhesion barrier, and a covering material. In certain embodiment, the covering material comprises an in situ polymerizing sealant. In certain embodiments, the in situ polymerizing sealant is a hydrogel which binds to the healthy tissue but remain unadhered to the area under the masking material. In certain embodiments, the masking material is also a hydrogel. In certain embodiments, normal biological processes may dissolve away the masking material leaving a protective cover of polymerized sealant over the wound site.Type: ApplicationFiled: July 22, 2008Publication date: March 18, 2010Applicant: HyperBranch Medical Technology, Inc.Inventors: Jeffrey G. Clark, Robert Naslund, Kenneth E. Stockman