Abstract: An asymmetric key cryptographic system is used to generate a cryptographic certificate for authenticating a memory module. This certificate is generated based on information, readable by the authenticator (e.g., host system), from at least one device on the memory module that is not read in order to obtain the certificate. For example, the certificate for authenticating a module may be stored in the nonvolatile memory of a serial presence detect device. The certificate itself, however, is based at least in part on information read from at least one other device on the memory module. Examples of this other device include a registering clock driver, DRAM device(s), and/or data buffer device(s). In an embodiment, the information read from a device (e.g., DRAM) may be based on one or more device fingerprint(s) derived from physical variations that occur naturally, and inevitably, during integrated circuit manufacturing.

Abstract: A debris collection and metrology system for collecting and analyzing debris from a tip used in nanomachining processes, the system including an irradiation source, an irradiation detector, an actuator, and a controller. The irradiation source is operable to direct incident irradiation onto the tip, and the irradiation detector is operable to receive a sample irradiation from the tip, the sample irradiation being generated as a result of the direct incident irradiation being applied onto the tip. The controller is operatively coupled to an actuator system and the irradiation detector, and the controller is operable to receive a first signal based on a first response of the irradiation detector to the sample irradiation, and the controller is operable to effect relative motion between the tip and at least one of the irradiation source and the irradiation detector based on the first signal.

Abstract: A plaque detection method and apparatus wherein at least one processor is programmed to receive above focus images to detect the presence of live cells without detecting the lysed cell materials, receive below focus images wherein virtual dark regions exist which are similar to cell shadows as seeds in a segmentation process and use contours around each resulting shape to obtain a subset that are more likely to be part of the cell population to define a cell map. A distance map is created in which each pixel value is the distance of that pixel from the nearest pixel of the cell map and the distance map is thresholded to create a first image of the places which are relatively far from the cells a second image with a smaller distance threshold to get an image that mimics the edges of the cells.

Abstract: Zero emission nested-loop (ZEN) reforming provides a scalable, eco-friendly process to produce high quality hydrogen at a relatively low operating cost. In one embodiment, a ZEN system comprises a reactor, a regenerator, and a photocatalytic reformer. During operation, the reactor receives a gas mixture and outputs hydrogen and catalyst adsorbed with carbon dioxide. The gas mixture is methane, steam, or hydrogen. Next, the regenerator receives the catalyst adsorbed with carbon dioxide and outputs carbon dioxide and desorbed catalyst. Next, the photocatalytic reformer receives carbon dioxide output by the regenerator and outputs methane and oxygen. The reactor receives at least some of the methane output by the photocatalytic reformer. By recycling methane in this way, the need for additional methane to fuel the system is reduced. The ZEN reforming system provides a novel technique to convert greenhouse gas emissions and carbon dioxide into oxygen and reusable methane gas.

Abstract: The present disclosure relates to configuring and operating Internet of things (IoT) elements connected by a network. A computing device receives an interface component corresponding to an IoT element. The computing device retrieves a description of the interface component at least describing a set of restrictions of an operation of the IoT element. The computing device deploys the interface component in the computing device to at least translate events and commands specific to the IoT element to common events and commands for processing in the computing device. The computing device sends at least a subset of the description of the interface component to a user device to cause the user device to generate a user interface for configuring the operation of the IoT element.

Abstract: The present disclosure relates to configuring and operating Internet of things (IoT) elements connected by a network. A computing device receives an interface component corresponding to an IoT element. The computing device retrieves a description of the interface component at least describing a set of restrictions of an operation of the IoT element. The computing device deploys the interface component in the computing device to at least translate events and commands specific to the IoT element to common events and commands for processing in the computing device. The computing device sends at least a subset of the description of the interface component to a user device to cause the user device to generate a user interface for configuring the operation of the IoT element.

Abstract: A method of treating a subject can include administering to a subject in need thereof an effective amount of a killer cell lectin-like receptor G1 (KLRG1)/ligand binding agent, thereby disrupting KLRG1 signaling and activating CD8+ cytotoxic T and/or NK cells. A method of treating cancer can include administering to a subject in need thereof an effective amount of a killer cell lectin-like receptor G1 (KLRG1)/ligand binding agent. The methods can treat various cancers, for example melanoma, lung cancer, pancreatic cancer, glioma, breast cancer, and ovarian cancer.

Abstract: A drill bit for removing subterranean formation material in a borehole comprises a bit body comprising a longitudinal axis, a plurality of blades extending radially outward from the longitudinal axis along a face region of the bit body and extending axially along a gauge region of the bit body, and an insert coupled to at least one blade in the gauge region. The insert comprises an elongated body having an upper surface, a lower surface, and a longitudinal axis extending centrally therethrough and intersecting the upper and lower surfaces. The upper surface comprises a bearing surface for supporting for the drill bit and providing a surface on which the subterranean formation being drilled rubs against the insert without exceeding the compressive strength of the selected formation. The insert is coupled to the blade such that the upper surface thereof extends radially beyond an outer surface of the blade and the lower surface thereof extends radially below the outer surface of the blade.

Abstract: This invention discloses a method for separation of an aromatic compound from a mixture comprising an alkane using an improved thin-film composite membrane. The membrane is particularly useful for separation of benzene from cyclohexane, which have similar boiling points. The membrane comprises a more mechanically durable and defect-free separation layer as a result of its fabrication from an ionomer solution that is substantially free of dissolved ionic species not associated with the ionomer.

Abstract: The receptor killer cell lectin-like receptor G1 (KLRG1) is expressed on T and NK cells, which binds to ligands on epithelial and mesenchymal cells. The ligand for KLRG1 has been described to be E-cadherin, N-cadherin, and R-cadherin. The present disclosure relates to and results from the discovery and characterization of antibodies that bind the extracellular domain (ECD) of KLRG1 but do not interfere with its interaction with the ligands E-cadherin, N-cadherin, and R-cadherin. The antibodies described have been derived by mouse hybridoma technology, and can be humanized by grafting their complementary determining regions (CDRs) into a human framework. The antibodies described can be used as effective therapeutic agents. Various antibodies, or antigen-binding fragments of such antibodies, along with various therapeutic and/or diagnostic methods, among other features, are provided for in the present disclosure.

Abstract: The receptor killer cell lectin-like receptor G1 (KLRG1) is expressed on T and NK cells, which binds to ligands on epithelial and mesenchymal cells. The ligand for KLRG1 has been described to be E-cadherin, N-cadherin, and R-cadherin. The present disclosure relates to and results from the discovery and characterization of antibodies that bind the extracellular domain (ECD) of KLRG1 but do not interfere with its interaction with the ligands E-cadherin, N-cadherin, and R-cadherin. The antibodies described have been derived by mouse hybridoma technology, and can be humanized by grafting their complementary determining regions (CDRs) into a human framework. The antibodies described can be used as effective therapeutic agents. Various antibodies, or antigen-binding fragments of such antibodies, along with various therapeutic and/or diagnostic methods, among other features, are provided for in the present disclosure.

Abstract: The invention relates to antibodies, or antigen-binding fragments thereof, that specifically binds to killer cell lectin-like receptor G1 (KLRG1). Such antibodies, or antigen-binding fragments thereof, are useful for various therapeutic or diagnostic purposes including treatment of cancers and to increase the effectiveness of vaccines.

Abstract: An improved method for humidification of a facilitated-transport membrane incorporates delivering a non-selective hydration fluid incorporating liquid water to a permeate side of a pressure vessel containing the facilitated transport membrane. The non-selective hydration fluid includes water and may be configured on the permeate side interface of the facilitated-transport membrane as a liquid or a gas. A process for separation of components in a gaseous mixture utilizing the method for humidification produces higher permeation of gasses through the facilitated transport membrane. The non-selective hydration fluid may be static or flowing and is non-selective for the permeance of certain permeate-gas components over other components.

Abstract: The present disclosure relates to configuring and operating Internet of things (IoT) elements connected by a network. A computing device receives a request to generate a rule for coordinating operation of a plurality of IoT elements. The computing device determines whether the request satisfies restrictions as described in descriptions of interface components of the plurality of IoT elements in the computing device by referencing descriptions of interface components. The interface components correspond to the plurality of IoT elements. The computing device generates the rule responsive to determining that the request satisfies the restrictions, and sends an action signal over the network based on the rule to operate one or more of the plurality of IoT elements.

Abstract: A weight resistance training machine is provided that is used to exercise the glute muscles of a user. The weight resistance training machine includes a carriage member that a user may mount to use the training machine. The carriage member may be mounted on a track system that allows the carriage member to translate linearly when the weight training machine is used. When a foot press bar connected to the carriage member is extended, the carriage member is linear translated by a cable and pulley system to increase the muscle path length during exercise and increase the exercise's efficacy.

Abstract: An attachment is provided that may be used to convert exercise equipment typically used in gyms to equipment that may be used by persons in wheelchairs. The attachment generally includes an upper frame member and a lower frame member, each of which are selectively engageable with the existing equipment. The upper frame member provides an adjustable back pad that can be used with an adjustable belt to stabilize the exerciser's upper body when using the equipment. The lower frame member includes wheel locks to stabilize the wheelchair after it has been rolled into the lower frame member. It may further include fork members to secure handles and cables of the existing machine to make them more accessible for the wheelchair user. A lap belt of the lower frame member may allow a user to stabilize his or her lower body relative to the wheelchair when using the equipment.

Abstract: A drill bit for removing subterranean formation material in a borehole comprises a bit body comprising a longitudinal axis, a plurality of blades extending radially outward from the longitudinal axis along a face region of the bit body and extending axially along a gauge region of the bit body, and an insert coupled to at least one blade in the gauge region. The insert comprises an elongated body having an upper surface, a lower surface, and a longitudinal axis extending centrally therethrough and intersecting the upper and lower surfaces. The upper surface comprises a bearing surface for supporting for the drill bit and providing a surface on which the subterranean formation being drilled rubs against the insert without exceeding the compressive strength of the selected formation. The insert is coupled to the blade such that the upper surface thereof extends radially beyond an outer surface of the blade and the lower surface thereof extends radially below the outer surface of the blade.

Abstract: The present disclosure relates to configuring and operating Internet of things (IoT) elements connected by a network. A computing device receives a request to generate a rule for coordinating operation of a plurality of IoT elements. The computing device determines whether the request satisfies restrictions as described in descriptions of interface components of the plurality of IoT elements in the computing device by referencing descriptions of interface components. The interface components correspond to the plurality of IoT elements. The computing device generates the rule responsive to determining that the request satisfies the restrictions, and sends an action signal over the network based on the rule to operate one or more of the plurality of IoT elements.

Abstract: This invention discloses a method for separation of an aromatic compound from a mixture comprising an alkane using an improved thin-film composite membrane. The membrane is particularly useful for separation of benzene from cyclohexane, which have similar boiling points. The membrane comprises a more mechanically durable and defect-free separation layer as a result of its fabrication from an ionomer solution that is substantially free of dissolved ionic species not associated with the ionomer.

Abstract: A back exercise machine includes: a resistance element; a user support; a first movement element, the first movement element having: a column; and a first connecting element having a pivot point such that the user support is able to pivot about a first axis associated with the first connecting element, wherein the first connecting element is movably coupled to the column such that the first connecting element is able to move along a path defined by the column; and a second movement element, the second movement element having: a rail; and a second connecting element having a pivot point such that the user support is able to pivot about a second axis associated with the second connecting element, wherein the second connecting element is movably coupled to the rail such that the second connecting element is able to move along a path defined by the rail.