Abstract: Devices and methods for deploying an anastomotic stent between portions of the gastro-intestinal (GI) tract are disclosed. The anastomotic stents are configured to atraumatically engage the tissue walls and to permit the flow of fluid, partially digested food, and food. The stents can be deployed using endoscopic catheter devices, laparoscopic tools, and combinations of both endoscopic tools and laparoscopic tools. Examples of anastomoses include anastomoses between the stomach and a portion of the intestines such as the jejunum. Anastomoses can also be formed between two closed ends of the intestines, such as two closed ends of the colon formed during a colon resection procedure. Anastomoses can also be formed between a fundal pouch formed during a gastric bypass procedure and the jejunum. Laparoscopic tools are disclosed to deploy a stent by selectively removing a radial restraint on a self expanding stent with the restraint removed through the laparoscopic access points.

Abstract: Provided is a suture tightening device, including: a first thread take-up wheel, a second thread take-up wheel, and a thread gear support detachably connected to an endoscope handle, wherein the first thread take-up wheel is arranged at a space from the second thread take-up wheel, and the first thread take-up wheel and the second thread take-up wheel are separately in rotatable connection to the thread gear support.

Abstract: The present disclosure provides a lock-cut mechanism and a medical suturing device, which relates to the technical field of medical suturing. The lock-cut mechanism includes: a plug head, an inner tube, an outer tube, a support, and a traction member. The inner tube is detachably connected to the support. The plug head is inserted into the inner tube, and the outer tube is sleeved on the inner tube and the support. The traction member passes through the outer tube, the inner tube, and the plug head, and a distal end of the traction member is provided with a protruding head. A side wall of the inner tube is provided with a first incision, and a side wall of the outer tube is provided with a second incision.

Abstract: The present disclosure provides a single-anchor mechanism and a suturing device. The single-anchor mechanism provided in the present disclosure includes: an anchor, a transmission tube, a traction wire, and a limiting element; one end of the traction wire is connected to the anchor, and the traction wire passes through the transmission tube; an end portion of the anchor opposite to the transmission tube is provided with an engaging portion adapted; the limiting element is connected to the traction wire, and the limiting element abuts against an end portion of the transmission tube away from the anchor.

Abstract: A tissue lumen stent is provided with a body having an elongated tubular configuration and a foreshortened configuration. In the foreshortened configuration, downstream and upstream ends of the body expand radially into downstream and upstream flange structures, leaving a generally cylindrical saddle region therebetween. In some embodiments, the flange structures are non-symmetrical with respect to one another. Systems and methods of using the stents are also disclosed.

Abstract: Devices and methods for deploying an anastomotic stent between portions of the gastro-intestinal (GI) tract are disclosed. The anastomotic stents are configured to atraumatically engage the tissue walls and to permit the flow of fluid, partially digested food, and food. The stents can be deployed using endoscopic catheter devices, laparoscopic tools, and combinations of both endoscopic tools and laparoscopic tools. Examples of anastomoses include anastomoses between the stomach and a portion of the intestines such as the jejunum. Anastomoses can also be formed between two closed ends of the intestines, such as two closed ends of the colon formed during a colon resection procedure. Anastomoses can also be formed between a fundal pouch formed during a gastric bypass procedure and the jejunum. Laparoscopic tools are disclosed to deploy a stent by selectively removing a radial restraint on a self expanding stent with the restraint removed through the laparoscopic access points.

Abstract: The present embodiments provide apparatus and methods for treating tissue by applying a force to the tissue. In one embodiment, the apparatus comprises a deployable segment having a loop member formed at a distal region of the deployable segment. A frame is operatively coupled to the loop member. In some embodiments, the frame may be operatively coupled to the loop member by at least three lugs; each lug has a slit, and the loop member extends through each lug slit. The loop member includes a gauge diameter, the slit has an opening, and the slit opening may be narrower than the loop member gauge diameter.

Abstract: A tissue lumen stent is provided with a body having an elongated tubular configuration and a foreshortened configuration. In the foreshortened configuration, downstream and upstream ends of the body expand radially into downstream and upstream flange structures, leaving a generally cylindrical saddle region therebetween. In some embodiments, the flange structures are non-symmetrical with respect to one another. Systems and methods of using the stents are also disclosed.

Abstract: An intragastric device includes an elongated member having a proximal end and a distal end and an anchor connected to the elongated member. The anchor includes a stem, a first arch and a second arch, and a curvilinear element. The stem includes a proximal end and a distal end. The distal end of the stem is attached to the proximal end of the elongated member. Each arch has first and second ends and a proximal peak therebetween. The first end of each arch is attached to the proximal end of the stem, and the second end of each arch extends radially away from the stem. The curvilinear element connects the second end of the first arch to the second end of the second arch.

Abstract: The present invention relates to a device for endoscopy or endosonography-guided transluminal interventions whereby two luminal structures in the body may be drawn toward each other and a fluid conduit formed in between. The device may have a hollow central member to which is coupled a distal retention member and in one embodiment a proximal retention member. The retention members may each be positioned inside one of the luminal structures and expanded from a first condition to an expanded second condition having an increased radius. The length of the central member may be shortened and its diameter expanded to approximate the two retention members and thereby the luminal structures.

Abstract: The present invention relates to a device for endoscopy or endosonography-guided transluminal interventions whereby two luminal structures in the body may be drawn toward each other and a fluid conduit formed in between. The device may have a hollow central member to which is coupled a distal retention member and in one embodiment a proximal retention member. The retention members may each be positioned inside one of the luminal structures and expanded from a first condition to an expanded second condition having an increased radius. The length of the central member may be shortened and its diameter expanded to approximate the two retention members and thereby the luminal structures.

Abstract: An endoscopic attachment and an endoscopic system are provided. The endoscopic attachment includes a proximal portion configured to be coupled to an insertion tube of the endoscope; and a distal portion coupled to the proximal portion and extending forwardly from the proximal portion to a forward edge. The distal portion includes a first axial segment that extends from the proximal portion axially to the forward edge by a first axial length, defines a passage, and extends circumferentially entirely around an axis of the passage; and a second axial segment that extends a second axial length from the first axial segment to the forward edge, and extends circumferentially around the axis of the proximal portion less than 360 degrees over at least part of the second axial length. The endoscopic attachment allows for tissues to be cut more efficiently and/or effectively during ESD, POEM and other procedures.

Abstract: Transluminal access system includes a stent delivery catheter having a handle control mechanism. The catheter comprises a number of components for establishing an initial penetration between adjacent body lumens and subsequently implanting a stent or other luminal anchor therebetween. Manipulation of the stent components is achieved using control mechanisms on the handle while the handle is attached to an endoscope which provides access to a first body lumen.

Abstract: Described herein are methods for reversibly constraining an endoscope. A method may include positioning an elongate medical device or endoscope in a holder of a clamp. A method may include actuating the holder such that one or more of a first sidewall and a second sidewall of the holder move to a clamped configuration to exert a force on the endoscope. A method may include adjusting a pad of the clamp from a first position to a second position where the pad is in contact with the endoscope in the second position.

Abstract: Described herein are devices for reversibly constraining an endoscope. Such devices may comprise: a base positionable proximate a patient; a column extending vertically from the base; an arm extending horizontally from the column; and a clamp coupled to the arm. In some embodiments, the clamp comprises a holder comprising an annular ring defining an endoscope receiving area or a first sidewall and a second sidewall together defining an endoscope receiving area. The holder is transitionable between a first configuration in which the annular ring or the first and second sidewall are configured to set apart from an endoscope in the endoscope receiving area and a second configuration in which the annular ring or the first and second sidewall are configured to clamp the endoscope in the endoscope receiving area.

Abstract: Described herein are devices and related methods for occluding at least a portion of a bodily lumen during a procedure. In some embodiments, the device includes an inner shaft defining a lumen therethrough and a first aperture; and an outer shaft including a flexible member and defining a lumen therethrough and a second aperture positioned proximally on the outer shaft relative to the flexible member. The inner shaft extends through the lumen of the outer shaft, such that at least a portion of the outer shaft is axially translatable toward and away from the distal portion of the inner shaft. The flexible member is movable between an unexpanded configuration and an expanded configuration when at least a portion of the outer shaft is translated axially toward or away from the distal portion of the inner shaft. In some embodiments, the device and methods are used for endoscopy procedures.

Abstract: A gastrointestinal catheter for insertion into a treatment site in a patient, the treatment site including at least one of a first treatment site and a second treatment site, where the catheter includes at least one of a first and a second treatment member; the proximal portions of the first and second treatment members may be detachably or slidably conjoinable side by side; the distal portions of the first and second treatment members are separate from each other. The distal end of the first treatment member is configured for insertion into the first treatment site; the second treatment member is configured to be placed at a second treatment site. The distal end region of the first treatment member has an anchoring configuration adapted to anchor the distal end region within the first treatment site, the distal end region is further capable of elastically assuming a linear constrained configuration.

Abstract: Adjacent tissue layers can be accessed using a catheter device with a distal tip having a conductive portion including a first cutting feature and one or more projections extending from the first cutting feature towards an outer diameter of the distal tip. Electrical energy can be supplied to the conductive portion of the device to cut tissue. A stent can be delivered to form a fluid communication between the adjacent tissue layers.

Abstract: A tissue lumen stent is provided with a body having an elongated tubular configuration and a foreshortened configuration. In the foreshortened configuration, downstream and upstream ends of the body expand radially into downstream and upstream flange structures, leaving a generally cylindrical saddle region therebetween. In some embodiments, the flange structures are non-symmetrical with respect to one another. Systems and methods of using the stents are also disclosed.

Abstract: Described herein are devices for reversibly constraining an endoscope. Such devices may comprise: a base positionable proximate a patient; a column extending vertically from the base; an arm extending horizontally from the column; and a clamp coupled to the arm. In some embodiments, the clamp comprises a holder comprising an annular ring defining an endoscope receiving area or a first sidewall and a second sidewall together defining an endoscope receiving area. The holder is transitionable between a first configuration in which the annular ring or the first and second sidewall are configured to set apart from an endoscope in the endoscope receiving area and a second configuration in which the annular ring or the first and second sidewall are configured to clamp the endoscope in the endoscope receiving area.