Patents by Inventor Kenneth G. Carson

Kenneth G. Carson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY
    Publication number: 20240150321
    Abstract: The invention provides pyrazolylsulfonamide compounds, pharmaceutical compositions, their use for inhibiting mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), and their use in the treatment of a disease or condition, such as a proliferative disorder, inflammatory disorder, or autoimmune disorder.
    Type: Application
    Filed: August 25, 2023
    Publication date: May 9, 2024
    Inventors: Yingzhi Bi, Kenneth G. Carson, Geraldine Cirillo Harriman, Sundarapandian Thangapandian, Christian Josef Kuper, Sebastien Louis Degorce, Benjamin Paul Whittaker, Arwel Lewis, Maria Angel Palomero-Vazquez
  • PYRIDINYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY
    Publication number: 20240150365
    Abstract: The invention provides pyridinylsulfonamide compounds, pharmaceutical compositions, their use for inhibiting mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), and their use in the treatment of a disease or condition, such as a proliferative disorder, inflammatory disorder, or autoimmune disorder.
    Type: Application
    Filed: August 25, 2023
    Publication date: May 9, 2024
    Inventors: Yingzhi BI, Kenneth G. CARSON, Geraldine Cirillo HARRIMAN, Sundarapandian THANGAPANDIAN, Christian Josef KUPER, Sebastien Louis DEGORCE, Arwel LEWIS, Maria Angel PALOMERO-VAZQUEZ, Robert Stuart Laurie CHAPMAN
  • Substituted 5-hydroxyoxindoles and their use as analgesics and fever reducers
    Patent number: 10537552
    Abstract: The present invention provides compounds and compositions which are useful in methods for modulating pain and fevers in a subject. These compounds are of the structure of formula (I), wherein Rx-R4, X, Y, and Z are defined herein, or a pharmaceutically acceptable salt, solvate, or prodrug thereof to the subject. In one embodiment, the compound is 5-hydroxy-7-methyloxindole.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: January 21, 2020
    Assignee: Carafe Drug Innovation, LLC
    Inventors: John R. Carson, Robert B. Raffa, Kenneth G. Carson
  • SUBSTITUTED 5-HYDROXYOXINDOLES AND THEIR USE AS ANALGESICS AND FEVER REDUCERS
    Publication number: 20180256543
    Abstract: The present invention provides compounds and compositions which are useful in methods for modulating pain and fevers in a subject. These compounds are of the structure of formula (I), wherein Rx-R4, X, Y, and Z are defined herein, or a pharmaceutically acceptable salt, solvate, or prodrug thereof to the subject. In one embodiment, the compound is 5-hydroxy-7-methyloxindole.
    Type: Application
    Filed: May 3, 2016
    Publication date: September 13, 2018
    Inventors: John R. CARON, Robert B. RAFFA, Kenneth G. CARSON
  • Chemokine receptor antagonists and methods of use
    Patent number: 9663537
    Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: May 30, 2017
    Assignees: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kirin Co., Ltd.
    Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
  • CCR1 antagonists and methods of use thereof
    Patent number: 9334283
    Abstract: The invention provides compounds having the formula: wherein R1 is halogen. The invention also provides compositions comprising the compounds, and methods of treating diseases or disorders that comprise administering one or more of the compounds to a subject in need thereof. The disclosed compounds have CCR1 antagonist activity.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: May 10, 2016
    Assignee: MILLENNIUM PHARMACEUTICALS, INC.
    Inventors: Kenneth G. Carson, Geraldine C. B. Harriman, Shomir Ghosh
  • CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF
    Publication number: 20160031908
    Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
    Type: Application
    Filed: March 10, 2015
    Publication date: February 4, 2016
    Inventors: Jay R. LULY, Yoshisuke NAKASATO, Etsuo OHSHIMA, Geraldine C.B. HARRIMAN, Kenneth G. CARSON, Shomir GHOSH, Amy M. ELDER, Karen M. MATTIA
  • CCR1 ANTAGONISTS AND METHODS OF USE THEREOF
    Publication number: 20150005338
    Abstract: The invention provides compounds having the formula: wherein R1 is halogen. The invention also provides compositions comprising the compounds, and methods of treating diseases or disorders that comprise administering one or more of the compounds to a subject in need thereof. The disclosed compounds have CCR1 antagonist activity.
    Type: Application
    Filed: February 4, 2014
    Publication date: January 1, 2015
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Kenneth G. Carson, Geraldine C.B. Harriman, Shomir Ghosh
  • CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF
    Publication number: 20140371207
    Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
    Type: Application
    Filed: December 13, 2013
    Publication date: December 18, 2014
    Applicants: Kyowa Hakko Kirin Co., Ltd., Millennium Pharmaceuticals, Inc.
    Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C.B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
  • SUBSTITUTED PIPERAZINYL-PYRROLIDINE COMPOUNDS USEFUL AS CHEMOKINE RECEPTOR ANTAGONISTS
    Publication number: 20140364420
    Abstract: The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula I are provided: or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions for the inhibition of Chemokine Receptors and also for the treatment of various diseases, conditions, or disorders, including acute or chronic inflammatory disease, cancer or osteolytic bone disorders.
    Type: Application
    Filed: January 13, 2014
    Publication date: December 11, 2014
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Kenneth G. Carson, Shomir Ghosh, Prakash Raman, Francois Soucy, Qing Ye
  • Chemokine receptor antagonists and methods of use thereof
    Patent number: 8653096
    Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: February 18, 2014
    Assignees: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kirin Co., Ltd.
    Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
  • Substituted piperazinyl-pyrrolidine compounds useful as chemokine receptor antagonists
    Patent number: 8648197
    Abstract: The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula I are provided: or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions for the inhibition of Chemokine Receptors and also for the treatment of various diseases, conditions, or disorders, including acute or chronic inflammatory disease, cancer or osteolytic bone disorders.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: February 11, 2014
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Kenneth G. Carson, Shomir Ghosh, Prakash Raman, Francois Soucy, Qing Ye
  • SUBSTITUTED PIPERAZINYL-PYRROLIDINE COMPOUNDS USEFUL AS CHEMOKINE RECEPTOR ANTAGONISTS
    Publication number: 20130123270
    Abstract: The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula I are provided: or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions for the inhibition of Chemokine Receptors and also for the treatment of various diseases, conditions, or disorders, including acute or chronic inflammatory disease, cancer or osteolytic bone disorders.
    Type: Application
    Filed: March 26, 2012
    Publication date: May 16, 2013
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Kenneth G. Carson, Prakash Raman, Francois Soucy, Qing Ye, Shomir Ghosh
  • Methods of treating ulcerative colitis
    Patent number: 8404732
    Abstract: Methods of treating and managing ulcerative colitis, using imidazole-based compounds that inhibit S1P lyase, are disclosed.
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: March 26, 2013
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: David J. Augeri, Jeffrey Bagdanoff, Lakmal W. Boteju, Kenneth G. Carson, Theodore C. Jessop, Spencer David Kimball
  • Compounds useful as chemokine receptor antagonists
    Patent number: 8399455
    Abstract: The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula I are provided: or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions for the inhibition of Chemokine Receptors and also for the treatment of various diseases, conditions, or disorders, including acute or chronic inflammatory disease, cancer, and osteolytic bone disorders.
    Type: Grant
    Filed: October 13, 2009
    Date of Patent: March 19, 2013
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Gerard Rosse, Linli Wei, Kenneth G. Carson
  • CCR1 antagonists and methods of use therefor
    Patent number: 8394817
    Abstract: The invention provides compounds having the formula: wherein R1 is halogen. The invention also provides compositions comprising the compounds, and methods of treating diseases or disorders that comprise administering one or more of the compounds to a subject in need thereof. The disclosed compounds have CCR1 antagonist activity.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: March 12, 2013
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Kenneth G. Carson, Geraldine C. B. Harriman, Shomir Ghosh
  • METHODS OF TREATING ULCERATIVE COLITIS
    Publication number: 20130005775
    Abstract: Methods of treating and managing ulcerative colitis, using imidazole-based compounds that inhibit S1P lyase, are disclosed.
    Type: Application
    Filed: January 4, 2012
    Publication date: January 3, 2013
    Applicant: LEXICON PHARMACEUTICALS, INC.
    Inventors: David J. Augeri, Jeffrey Bagdanoff, Lakmal W. Boteju, Kenneth G. Carson, Theodore C. Jessop, Spencer David Kimball
  • Substituted piperazinyl-pyrrolidine compounds useful as chemokine receptor antagonists
    Patent number: 8168788
    Abstract: The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula I are provided: or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions for the inhibition of Chemokine Receptors and also for the treatment of various diseases, conditions, or disorders, including acute or chronic inflammatory disease, cancer or osteolytic bone disorders.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: May 1, 2012
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Kenneth G. Carson, Shomir Ghosh, Prakash Raman, Francois Soucy, Qing Ye
  • CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF
    Publication number: 20120046311
    Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
    Type: Application
    Filed: September 26, 2011
    Publication date: February 23, 2012
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
  • 4-amino-1H-pyrimidin-2-one based compounds, compositions comprising them and methods of their use
    Patent number: 8093245
    Abstract: 4-Amino-1H-pyrimidin-2-one-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of various diseases and disorders are disclosed.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: January 10, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: David J. Augeri, Marianne Carlsen, Kenneth G. Carson, Qinghong Fu, Alexander Heim-Riether, Theodore C. Jessop, James E. Tarver, Jerry A. Taylor