Patents by Inventor Kenneth G. Chahine
Kenneth G. Chahine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210082578Abstract: Described are methods for identification of likelihood of health outcomes such as the development of a medical condition using health histories from genetically related individuals. Embodiments include: receiving a first set of genetic data associated with the human subject; comparing the first set of genetic data to a plurality of sets of genetic data from a plurality of other individuals; identifying from the comparison a family network comprising individuals genetically related to the human subject as defined by identity by descent; receiving a set of health history data for each individual and each individual in the family network; analyzing the set of health history data to generate a health outcome score for the human subject, the health outcome score being a measure of risk for the human subject to develop a pre-defined health outcome that is associated with the health outcome score; and reporting the health outcome score.Type: ApplicationFiled: November 16, 2020Publication date: March 18, 2021Inventors: Catherine A. Ball, Kenneth G. Chahine, Mathew J. Barber, Julie M. Granka
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Patent number: 10867705Abstract: Described are methods for identification of likelihood of health outcomes such as the development of a medical condition using health histories from genetically related individuals. Embodiments include: receiving a first set of genetic data associated with the human subject; comparing the first set of genetic data to a plurality of sets of genetic data from a plurality of other individuals; identifying from the comparison a family network comprising individuals genetically related to the human subject as defined by identity by descent; receiving a set of health history data for each individual and each individual in the family network; analyzing the set of health history data to generate a health outcome score for the human subject, the health outcome score being a measure of risk for the human subject to develop a pre-defined health outcome that is associated with the health outcome score; and reporting the health outcome score.Type: GrantFiled: November 6, 2015Date of Patent: December 15, 2020Assignee: AncestryHealth.com, LLCInventors: Catherine A. Ball, Kenneth G. Chahine, Mathew J. Barber, Julie M. Granka
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Publication number: 20200303035Abstract: Novel haplotype cluster Markov models are used to phase genomic samples. After the models are built, they rapidly and accurately phase new samples without requiring that the new samples be used to re-build the models. The models set transition probabilities such that the probability for an appearance of any allele within any haplotype is a non-zero number. Furthermore, the most unlikely pairs of haplotypes are discarded from each model at each level until ? of the likelihood mass at each level is discarded. The models are also constructed such that contributing windows of SNPs partially overlap so that phasing decisions near one of the extreme ends of any model is are not significantly determinative of the phase. Additionally, the models are configured such that two or more nodes can be merged during the building/updating procedure to consolidate haplotype clusters having similar distributions.Type: ApplicationFiled: April 29, 2020Publication date: September 24, 2020Inventors: Catherine Ann Ball, Keith D. Noto, Kenneth G. Chahine, Mathew J. Barber, Yong Wang
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Publication number: 20200286591Abstract: System, computer program products, and methods are disclosed for estimating a degree of ancestral relatedness between two individuals. The haplotype data for a population of individuals is divided into segment windows based on genetic markers, and matched segments for the haplotype data are generated. Each matched segment having a first cM width that exceeds a threshold cM width is included in counting the matched segments in each segment window. A weight associated with each segment window is estimated based on the count of matched segments in the associated segment window. A weighted sum of per-window cM widths for each matched segment is calculated based on the first cM width and the weights associated with the segment windows of the matched segment. The weighted sum of per-window cM widths are used to estimate a degree of ancestral relatedness between two individuals.Type: ApplicationFiled: May 27, 2020Publication date: September 10, 2020Inventors: Mathew J. Barber, Yong Wang, Keith D. Noto, Kenneth G. Chahine, Catherine Ann Ball
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Patent number: 10720229Abstract: System, computer program products, and methods are disclosed for estimating a degree of ancestral relatedness between two individuals. The haplotype data for a population of individuals is divided into segment windows based on genetic markers, and matched segments for the haplotype data are generated. Each matched segment having a first cM width that exceeds a threshold cM width is included in counting the matched segments in each segment window. A weight associated with each segment window is estimated based on the count of matched segments in the associated segment window. A weighted sum of per-window cM widths for each matched segment is calculated based on the first cM width and the weights associated with the segment windows of the matched segment. The weighted sum of per-window cM widths are used to estimate a degree of ancestral relatedness between two individuals.Type: GrantFiled: October 14, 2015Date of Patent: July 21, 2020Assignee: Ancestry.com DNA, LLCInventors: Mathew J Barber, Yong Wang, Keith D. Noto, Kenneth G. Chahine, Catherine Ann Ball
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Patent number: 10679729Abstract: Novel haplotype cluster Markov models are used to phase genomic samples. After the models are built, they rapidly and accurately phase new samples without requiring that the new samples be used to re-build the models. The models set transition probabilities such that the probability for an appearance of any allele within any haplotype is a non-zero number. Furthermore, the most unlikely pairs of haplotypes are discarded from each model at each level until c of the likelihood mass at each level is discarded. The models are also constructed such that contributing windows of SNPs partially overlap so that phasing decisions near one of the extreme ends of any model is are not significantly determinative of the phase. Additionally, the models are configured such that two or more nodes can be merged during the building/updating procedure to consolidate haplotype clusters having similar distributions.Type: GrantFiled: October 19, 2015Date of Patent: June 9, 2020Assignee: Ancestry.com DNA, LLCInventors: Catherine Ann Ball, Keith D. Noto, Kenneth G. Chahine, Mathew J. Barber, Yong Wang
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Publication number: 20180301227Abstract: Described are methods for identification of likelihood of health outcomes such as the development of a medical condition using health histories from genetically related individuals. Embodiments include: receiving a first set of genetic data associated with the human subject; comparing the first set of genetic data to a plurality of sets of genetic data from a plurality of other individuals; identifying from the comparison a family network comprising individuals genetically related to the human subject as defined by identity by descent; receiving a set of health history data for each individual and each individual in the family network; analyzing the set of health history data to generate a health outcome score for the human subject, the health outcome score being a measure of risk for the human subject to develop a pre-defined health outcome that is associated with the health outcome score; and reporting the health outcome score.Type: ApplicationFiled: November 6, 2015Publication date: October 18, 2018Inventors: Catherine A. BALL, Kenneth G. CHAHINE, Mathew J. BARBER, Julie M. GRANKA
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Publication number: 20170262577Abstract: Novel haplotype cluster Markov models are used to phase genomic samples. After the models are built, they rapidly and accurately phase new samples without requiring that the new samples be used to re-build the models. The models set transition probabilities such that the probability for an appearance of any allele within any haplotype is a non-zero number. Furthermore, the most unlikely pairs of haplotypes are discarded from each model at each level until c of the likelihood mass at each level is discarded. The models are also constructed such that contributing windows of SNPs partially overlap so that phasing decisions near one of the extreme ends of any model is are not significantly determinative of the phase. Additionally, the models are configured such that two or more nodes can be merged during the building/updating procedure to consolidate haplotype clusters having similar distributions.Type: ApplicationFiled: October 19, 2015Publication date: September 14, 2017Inventors: Catherine Ann BALL, Keith D. NOTO, Kenneth G. CHAHINE, Mathew J. BARBER, Yong WANG
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Patent number: 9732376Abstract: A sample collection device having a sample tube, funnel, and cap having a capsule and a piercing insert, the capsule having a stabilization solution. After depositing the sample into the tube via the funnel, the cap is screwed onto the tube, piercing the capsule and releasing the stabilization fluid into the tube. The device can be used at home without clinicial supervision for collecting a saliva sample and transporting the sample to an analysis location for DNA analysis.Type: GrantFiled: July 31, 2014Date of Patent: August 15, 2017Assignee: ANCESTRY.COM DNA, LLC.Inventors: Benjamin J. Oyler, Kenneth G. Chahine, Catherine Ann Ball, Federico C. A. Gaeta
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Publication number: 20170220738Abstract: System, computer program products, and methods are disclosed for estimating a degree of ancestral relatedness between two individuals. The haplotype data for a population of individuals is divided into segment windows based on genetic markers, and matched segments for the haplotype data are generated. Each matched segment having a first cM width that exceeds a threshold cM width is included in counting the matched segments in each segment window. A weight associated with each segment window is estimated based on the count of matched segments in the associated segment window. A weighted sum of per-window cM widths for each matched segment is calculated based on the first cM width and the weights associated with the segment windows of the matched segment. The weighted sum of per-window cM widths are used to estimate a degree of ancestral relatedness between two individuals.Type: ApplicationFiled: October 14, 2015Publication date: August 3, 2017Inventors: Mathew J BARBER, Yong WANG, Keith D. NOTO, Kenneth G. CHAHINE, Catherine Ann BALL
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Publication number: 20150056716Abstract: A sample collection device having a sample tube, funnel, and cap having a capsule and a piercing insert, the capsule having a stabilization solution. After depositing the sample into the tube via the funnel, the cap is screwed onto the tube, piercing the capsule and releasing the stabilization fluid into the tube. The device can be used at home without clinicial supervision for collecting a saliva sample and transporting the sample to an analysis location for DNA analysis.Type: ApplicationFiled: July 31, 2014Publication date: February 26, 2015Inventors: Benjamin J. Oyler, Kenneth G. Chahine, Catherine Ann Ball, Federico C.A. Gaeta