Patents by Inventor Kenneth G. Olson
Kenneth G. Olson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190194765Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: ApplicationFiled: February 27, 2019Publication date: June 27, 2019Applicant: GeneWeave Biosciences, Inc.Inventors: Diego Ariel REY, Shaunak ROY, Leonardo Maestri TEIXEIRA, Ryan C. GRISWOLD, Kenneth G. OLSON, Bruce J. RICHARDSON, Victor H. YEE, Werner FREI
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Patent number: 10240212Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: GrantFiled: December 22, 2016Date of Patent: March 26, 2019Assignee: GeneWeave Biosciences, Inc.Inventors: Diego Ariel Rey, Shaunak Roy, Leonardo Maestri Teixeira, Ryan C. Griswold, Kenneth G. Olson, Bruce J. Richardson, Victor H. Yee, Werner Frei
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Patent number: 10125386Abstract: An apparatus includes a housing and an actuator. The housing, which defines a reagent volume that can receive a reagent container, can be removably coupled to a reaction chamber. The housing includes a puncturer that defines a transfer pathway in fluid communication with the reagent volume. A delivery portion of the housing defines a delivery pathway between the transfer pathway and the reaction chamber when the housing is coupled to the reaction chamber. The actuator has a plunger portion disposed within the reagent volume. An engagement portion of the actuator can be manipulated to move the plunger portion within the reagent volume to deform the reagent container. The puncturer can pierce a frangible portion of the reagent container to convey a reagent from the reagent container into the reaction chamber via the transfer pathway and/or the delivery pathway.Type: GrantFiled: November 30, 2016Date of Patent: November 13, 2018Assignee: GeneWeave Biosciences, Inc.Inventors: Nikol De Forest, Werner Frei, Diego Rey, Shaunak Roy, Soni Shukla, Ryan C. Griswold, Kenneth G. Olson, Bruce J. Richardson, Victor H. Yee
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Publication number: 20170233783Abstract: An apparatus includes a housing and an actuator. The housing, which defines a reagent volume that can receive a reagent container, can be removably coupled to a reaction chamber. The housing includes a puncturer that defines a transfer pathway in fluid communication with the reagent volume. A delivery portion of the housing defines a delivery pathway between the transfer pathway and the reaction chamber when the housing is coupled to the reaction chamber. The actuator has a plunger portion disposed within the reagent volume. An engagement portion of the actuator can be manipulated to move the plunger portion within the reagent volume to deform the reagent container. The puncturer can pierce a frangible portion of the reagent container to convey a reagent from the reagent container into the reaction chamber via the transfer pathway and/or the delivery pathway.Type: ApplicationFiled: November 30, 2016Publication date: August 17, 2017Applicant: GeneWeave Biosciences, Inc.Inventors: Nikol DE FOREST, Werner FREI, Diego Rey, Shaunak Roy, Soni SHUKLA, Ryan C. GRISWOLD, Kenneth G. OLSON, Bruce J. RICHARDSON, Victor H. Yee
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Publication number: 20170152576Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: ApplicationFiled: December 22, 2016Publication date: June 1, 2017Applicant: GeneWeave Biosciences, Inc.Inventors: Diego Ariel REY, Shaunak ROY, Leonardo Maestri TEIXEIRA, Ryan C. GRISWOLD, Kenneth G. OLSON, Bruce J. RICHARDSON, Victor H. YEE
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Patent number: 9546391Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: GrantFiled: September 8, 2014Date of Patent: January 17, 2017Assignee: GeneWeave Biosciences, Inc.Inventors: Diego Ariel Rey, Shaunak Roy, Werner Frei, Bruce J. Richardson, Ryan C. Griswold, Damian S. Matthews, Kenneth G. Olson, Victor H. Yee
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Patent number: 9540675Abstract: An apparatus includes a housing and an actuator. The housing, which defines a reagent volume that can receive a reagent container, can be removably coupled to a reaction chamber. The housing includes a puncturer that defines a transfer pathway in fluid communication with the reagent volume. A delivery portion of the housing defines a delivery pathway between the transfer pathway and the reaction chamber when the housing is coupled to the reaction chamber. The actuator has a plunger portion disposed within the reagent volume. An engagement portion of the actuator can be manipulated to move the plunger portion within the reagent volume to deform the reagent container. The puncturer can pierce a frangible portion of the reagent container to convey a reagent from the reagent container into the reaction chamber via the transfer pathway and/or the delivery pathway.Type: GrantFiled: February 9, 2015Date of Patent: January 10, 2017Assignee: GeneWeave Biosciences, Inc.Inventors: Nikol De Forest, Werner Frei, Diego Rey, Shaunak Roy, Soni Shukla, Ryan C. Griswold, Kenneth G. Olson, Bruce J. Richardson, Victor H. Yee
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Patent number: 9481903Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: GrantFiled: March 13, 2013Date of Patent: November 1, 2016Assignee: Roche Molecular Systems, Inc.Inventors: Diego Ariel Rey, Shaunak Roy, Leonardo Maestri Teixeira, Ryan C. Griswold, Kenneth G. Olson, Bruce J. Richardson, Victor Yee
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Patent number: 9133497Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: GrantFiled: February 2, 2015Date of Patent: September 15, 2015Assignee: GeneWeave Biosciences, Inc.Inventors: Werner Frei, Diego Ariel Rey, Shaunak Roy, Ryan C. Griswold, Kenneth G. Olson, Bruce J. Richardson, Rick V. Stellmacher
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Publication number: 20150218613Abstract: An apparatus includes a housing and an actuator. The housing, which defines a reagent volume that can receive a reagent container, can be removably coupled to a reaction chamber. The housing includes a puncturer that defines a transfer pathway in fluid communication with the reagent volume. A delivery portion of the housing defines a delivery pathway between the transfer pathway and the reaction chamber when the housing is coupled to the reaction chamber. The actuator has a plunger portion disposed within the reagent volume. An engagement portion of the actuator can be manipulated to move the plunger portion within the reagent volume to deform the reagent container. The puncturer can pierce a frangible portion of the reagent container to convey a reagent from the reagent container into the reaction chamber via the transfer pathway and/or the delivery pathway.Type: ApplicationFiled: February 9, 2015Publication date: August 6, 2015Applicant: GeneWeave Biosciences, Inc.Inventors: Nikol DE FOREST, Werner FREI, Diego REY, Shaunak ROY, Soni SHUKLA, Ryan C. GRISWOLD, Kenneth G. OLSON, Bruce J. RICHARDSON, Victor H. YEE
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Publication number: 20150148261Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: ApplicationFiled: February 2, 2015Publication date: May 28, 2015Applicant: GENEWEAVE BIOSCIENCES, INC.Inventors: Werner FREI, Diego Ariel REY, Shaunak ROY, Ryan C. GRISWOLD, Kenneth G. OLSON, Bruce J. RICHARDSON, Rick V. STELLMACHER
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Publication number: 20140273180Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: ApplicationFiled: October 8, 2013Publication date: September 18, 2014Applicant: GENEWEAVE BIOSCIENCES, INC.Inventors: Ryan C. GRISWOLD, Kenneth G. OLSON, Bruce J. RICHARDSON, Rick V. STELLMACHER, Victor H. YEE
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Patent number: 8829473Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: GrantFiled: October 8, 2013Date of Patent: September 9, 2014Assignee: GeneWeave Biosciences, Inc.Inventors: Ryan C. Griswold, Kenneth G. Olson, Bruce J. Richardson, Rick V. Stellmacher, Victor H. Yee
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Patent number: 6320960Abstract: A headset has an earpiece and a flexible microphone boom. The headset is designed and constructed to be lightweight, flexibly adjustable, and comfortable to wear. The earpiece fits comfortably over an external portion of an ear of a wearer and between a head of the wearer and the ear. The earpiece is designed to be easily adjusted for a secure, comfortable fit. In the preferred embodiment, the earpiece includes a rigid plastic backbone and a ductile wire. In an alternate embodiment, the earpiece includes a rigid plastic backbone, a spring, and a ductile wire. The earpiece has an asymmetrical U shape, facilitating easy adjustment to fit securely around the external portion of the ear. A speaker module is coupled to the earpiece and designed to rest over a pinna of the ear when the earpiece is worn over the ear. A small speaker is mounted inside the speaker module. The speaker module is coupled to the earpiece by a ball and socket joint integrally formed as part of the earpiece.Type: GrantFiled: September 24, 1999Date of Patent: November 20, 2001Assignee: Hello Direct, Inc.Inventors: Robert L. Lathrop, III, Richard J. Lutzinger, Kenneth G. Olson, John H. Magnasco
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Patent number: 5820957Abstract: An anti-reflective film construction contains an optically transparent polymeric film having a textured surface and an optically transparent adhesive, the film construction configured to exhibit light transmission of greater than about 70 percent and 60.degree. gloss measurement of between about 15 and 100. Methods of producing such film constructions and methods of reducing reflection from a surface are also described.Type: GrantFiled: May 6, 1996Date of Patent: October 13, 1998Assignee: Minnesota Mining and Manufacturing CompanyInventors: Kristin M. Schroeder, Brian L. Koster, Timothy T. Magill, Kenneth G. Olson, Takashi Harada
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Patent number: D436095Type: GrantFiled: September 24, 1999Date of Patent: January 9, 2001Assignee: Hello Direct, Inc.Inventors: Peter Otto Schmidt, Robert L. Lathrop, III, Richard J. Lutzinger, Kenneth G. Olson, John H. Magnasco
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Patent number: D387867Type: GrantFiled: March 24, 1995Date of Patent: December 16, 1997Assignee: Acuson CorporationInventors: Richard W. Henderson, Robert Mesaros, Michael J. Conroy, Kenneth G. Olson
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Patent number: D389912Type: GrantFiled: November 27, 1996Date of Patent: January 27, 1998Assignee: Eclipse Surgical Technologies, Inc.Inventors: Rick Emerson, Kenneth G. Olson, Stuart D. Harman, Steven A. Daniel
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Patent number: D389915Type: GrantFiled: November 27, 1996Date of Patent: January 27, 1998Assignee: Eclipse Surgical Technologies, Inc.Inventors: Rick Emerson, Kenneth G. Olson, Steven A. Daniel
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Patent number: D405883Type: GrantFiled: December 23, 1996Date of Patent: February 16, 1999Assignee: Eclipse Surgical Technologies, Inc.Inventors: Rick Emerson, Kenneth G. Olson, Gabriele Bungardt, Stuart D. Harman