Patents by Inventor Kenneth Giuliano

Kenneth Giuliano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7853411
    Abstract: The present invention provides systems, methods, and screens to measure receptor internalization in a single step with appropriate automation and throughput. This approach involves luminescent labeling of the receptor of interest and the automated measurement of receptor internalization to a perinuclear location.
    Type: Grant
    Filed: October 15, 2003
    Date of Patent: December 14, 2010
    Assignee: Cellomics, Inc.
    Inventors: Richard Rubin, Kenneth Giuliano, Albert Gough, R. Terry Dunlay, Bruce Ray Conway
  • Publication number: 20090170091
    Abstract: The inventive method employs a “systems biology” approach to predicting biological responses resulting from exposure to the test substance. In one embodiment, the invention provides an automated method for predicting the biological systems effects of a test substance. In another embodiment, the invention provides a method for constructing a knowledgebase (or database) of response profiles for reference substances with known biological systems effects. In another embodiment, the invention provides a set of protocols and software tools used to carry out the profiling. Another embodiment of the invention is a panel of reagents and protocols required for generating response profiles, either to create an knowledgebase, or to use with an existing knowledgebase and informatics software to profile substance physiological effects. Another embodiment of the invention is a database of physiological profiles.
    Type: Application
    Filed: January 17, 2007
    Publication date: July 2, 2009
    Inventors: Kenneth Giuliano, Albert H. Gough, Patricia A. Johnston, D. Lansing Taylor
  • Patent number: 7476510
    Abstract: Methods and cassettes for cell-based toxin detection and organ localization are disclosed. The cassettes includes an array containing cells and a matrix of openings or depressions, wherein each region of the substrate enclosed by the opening or depression in the matrix forms a domain individually addressable by microfluidic channels in the device.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: January 13, 2009
    Assignee: Cellomics, Inc.
    Inventors: Ravi Kapur, Kenneth Giuliano
  • Publication number: 20070166771
    Abstract: The present invention describes methods and cassettes for cell-based toxin detection and organ localization. The cassettes includes an array containing cells and a matrix of openings or depressions, wherein each region of the substrate enclosed by the opening or depression in the matrix forms a domain individually addressable by microfluidic channels in the device.
    Type: Application
    Filed: January 5, 2007
    Publication date: July 19, 2007
    Applicant: Cellomics, Inc.
    Inventors: Ravi Kapur, Kenneth Giuliano
  • Patent number: 7160687
    Abstract: The present invention describes methods and cassettes for cell-based toxin detection and organ localization. The cassettes includes an array containing cells and a matrix of openings or depressions, wherein each region of the substrate enclosed by the opening or depression in the matrix forms a domain individually addressable by microfluidic channels in the device.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: January 9, 2007
    Assignee: Cellomics, Inc.
    Inventors: Ravi Kapur, Kenneth Giuliano
  • Publication number: 20060094868
    Abstract: The present invention provides systems, methods, screens, reagents and kits for optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for those that specifically affect particular biological functions.
    Type: Application
    Filed: October 17, 2005
    Publication date: May 4, 2006
    Inventors: Kenneth Giuliano, Gary Bright, Keith Olson, Sarah Burroughs-Tencza
  • Patent number: 6875578
    Abstract: The present invention provides systems, methods, screens, reagents and kits for optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for those that specifically affect particular biological functions.
    Type: Grant
    Filed: March 19, 2002
    Date of Patent: April 5, 2005
    Assignee: Cellomics, Inc.
    Inventors: Kenneth Giuliano, Ravi Kapur
  • Publication number: 20030096322
    Abstract: The present invention provides systems, methods, screens, reagents and kits for optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for those that specifically affect particular biological functions.
    Type: Application
    Filed: March 19, 2002
    Publication date: May 22, 2003
    Applicant: Cellomics, Inc.
    Inventors: Kenneth Giuliano, Ravi Kapur
  • Patent number: 6416959
    Abstract: The present invention provides systems, methods, screens, reagents and kits for optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for those that specifically affect particular biological functions.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: July 9, 2002
    Inventors: Kenneth Giuliano, Ravi Kapur