Patents by Inventor Kenneth Gordon Carson

Kenneth Gordon Carson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of sodium glucose transporter 1 for constipation
    Patent number: 10106569
    Abstract: Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes are disclosed. Particular compounds are of the formula: the various substituents of which are defined herein.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: October 23, 2018
    Assignee: Lexicon Pharmaceutical, Inc.
    Inventors: Kenneth Gordon Carson, Nicole Cathleen Goodwin, Bryce Alden Harrison, David Brent Rawlins, Eric Strobel, Brian Zambrowicz
  • INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1
    Publication number: 20180244708
    Abstract: Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes are disclosed. Particular compounds are of the formula: the various substituents of which are defined herein.
    Type: Application
    Filed: May 22, 2017
    Publication date: August 30, 2018
    Inventors: Kenneth Gordon CARSON, Nicole Cathleen GOODWIN, Bryce Alden HARRISON, David Brent RAWLINS, Eric STROBEL, Brian ZAMBROWICZ
  • Inhibitors of sodium glucose cotransporter 1
    Patent number: 9688710
    Abstract: Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes are disclosed. Particular compounds are of the formula: the various substituents of which are defined herein.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: June 27, 2017
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Kenneth Gordon Carson, Nicole Cathleen Goodwin, Bryce Alden Harrison, David Brent Rawlins, Eric Strobel, Brian Zambrowicz
  • PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
    Publication number: 20170129896
    Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Application
    Filed: July 12, 2016
    Publication date: May 11, 2017
    Inventors: Yingzhi BI, Kenneth Gordon CARSON, Giovanni CIANCHETTA, Michael Alan GREEN, Godwin KUMI, Alan MAIN, Yulian ZHANG, Glenn Gregory ZIPP
  • 4H-thieno[3,2-C]chromene-based inhibitors of Notum Pectinacetylesterase and methods of their use
    Patent number: 9624238
    Abstract: Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: April 18, 2017
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Joseph Barbosa, Kenneth Gordon Carson, Michael Walter Gardyan, Jason Patrick Healy, Qiang Han, Ross Mabon, Praveen Pabba, James Tarver, Jr., Kristen M. Terranova, Ashok Tunoori, Xiaolian Xu
  • IMIDAZO[1,2-b]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
    Publication number: 20170057964
    Abstract: Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Application
    Filed: April 26, 2016
    Publication date: March 2, 2017
    Inventors: Yingzhi BI, Kenneth Gordon CARSON, Giovanni CIANCHETTA, Michael Alan GREEN, Godwin KUMI, Zhi LIANG, Ying Jade LIU, Alan MAIN, Yulian ZHANG, Glenn Gregory ZIPP
  • INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1
    Publication number: 20160326205
    Abstract: Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes are disclosed. Particular compounds are of the formula: the various substituents of which are defined herein.
    Type: Application
    Filed: November 17, 2015
    Publication date: November 10, 2016
    Inventors: Kenneth Gordon CARSON, Nicole Cathleen GOODWIN, Bryce Alden HARRISON, David Brent RAWLINS, Eric STROBEL, Brian ZAMBROWICZ
  • Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use
    Patent number: 9403832
    Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: August 2, 2016
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Yingzhi Bi, Kenneth Gordon Carson, Giovanni Cianchetta, Michael Alan Green, Godwin Kumi, Alan Main, Yulian Zhang, Glenn Gregory Zipp
  • IMIDAZO[1,2-b]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
    Publication number: 20160024093
    Abstract: Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Application
    Filed: February 25, 2015
    Publication date: January 28, 2016
    Inventors: Yingzhi BI, Kenneth Gordon CARSON, Giovanni CIANCHETTA, Michael Alan GREEN, Godwin KUMI, Zhi LIANG, Ying Jade LIU, Alan MAIN, Yulian ZHANG, Glenn Gregory ZIPP
  • Inhibitors of sodium glucose cotransporter 1
    Patent number: 9200025
    Abstract: Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes are disclosed. Particular compounds are of the formula: the various substituents of which are defined herein.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: December 1, 2015
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Kenneth Gordon Carson, Nicole Cathleen Goodwin, Bryce Alden Harrison, David Brent Rawlins, Eric Strobel, Brian Zambrowicz
  • PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
    Publication number: 20150183792
    Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Application
    Filed: September 11, 2014
    Publication date: July 2, 2015
    Inventors: Yingzhi BI, Kenneth Gordon CARSON, Giovanni CIANCHETTA, Michael Alan GREEN, Godwin KUMI, Alan MAIN, Yulian ZHANG, Gregory Glenn ZIPP
  • Imidazo[1,2-b]pyridazine-based compounds, compositions comprising them, and methods of their use
    Patent number: 8969565
    Abstract: Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: March 3, 2015
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Yingzhi Bi, Kenneth Gordon Carson, Giovanni Cianchetta, Michael Alan Green, Godwin Kumi, Zhi Liang, Ying Jade Liu, Alan Main, Yulian Zhang, Gregory Glenn Zipp
  • Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use
    Patent number: 8946415
    Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: February 3, 2015
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Yingzhi Bi, Kenneth Gordon Carson, Giovanni Cianchetta, Michael Alan Green, Godwin Kumi, Alan Main, Yulian Zhang, Gregory Glenn Zipp
  • INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1
    Publication number: 20140309178
    Abstract: Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes are disclosed. Particular compounds are of the formula: the various substituents of which are defined herein.
    Type: Application
    Filed: November 18, 2013
    Publication date: October 16, 2014
    Applicant: LEXICON PHARMACEUTICALS, INC.
    Inventors: Kenneth Gordon CARSON, Nicole Cathleen GOODWIN, Bryce Alden HARRISON, David Brent RAWLINS, Eric STROBEL, Brian ZAMBROWICZ
  • INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE
    Publication number: 20140288071
    Abstract: Compounds are disclosed for the treatment, management and prevention of diseases and disorders affecting the bone. Particular compounds are potent inhibitors of Notum Pectinacetylesterase, and are of the formula: wherein E, G, Y, Z, R1, R2, and R3 are defined herein.
    Type: Application
    Filed: June 10, 2014
    Publication date: September 25, 2014
    Inventors: Joseph BARBOSA, Kenneth Gordon CARSON, Michael Walter GARDYAN, Wei HE, Victoria LOMBARDO, Praveen PABBA, James TARVER, JR.
  • 4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE
    Publication number: 20140256784
    Abstract: Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.
    Type: Application
    Filed: May 21, 2014
    Publication date: September 11, 2014
    Inventors: Joseph BARBOSA, Kenneth Gordon CARSON, Michael Walter GARDYAN, Jason Patrick HEALY, Qiang HAN, Ross MABON, Praveen PABBA, James TARVER, JR., Kristen M. TERRANOVA, Ashok TUNOORI, Xiaolian XU
  • MST1 KINASE INHIBITORS AND METHODS OF THEIR USE
    Publication number: 20140051681
    Abstract: Compounds for the inhibition of mammalian Ste20-like kinase 1 (MST1) are disclosed, along with compositions comprising them and methods of their use in the treatment, management or prevention of an inflammatory or autoimmune diseases or disorders.
    Type: Application
    Filed: May 3, 2013
    Publication date: February 20, 2014
    Inventors: David John AUGERI, Jeffrey Thomas BAGDANOFF, Simon David Peter BAUGH, Marianne CARLSEN, Kenneth Gordon CARSON, John Anthony GILLERAN, Wei HE, Tamas ORAVECZ, Konstantin SALOJIN, Leonard SUNG
  • PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
    Publication number: 20130253194
    Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Application
    Filed: March 5, 2013
    Publication date: September 26, 2013
    Inventors: Yingzhi BI, Kenneth Gordon CARSON, Giovanni CIANCHETTA, Michael Alan GREEN, Godwin KUMI, Alan MAIN, Yulian ZHANG, Gregory Glenn ZIPP
  • IMIDAZO[1,2-b]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
    Publication number: 20130245021
    Abstract: Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Application
    Filed: March 5, 2013
    Publication date: September 19, 2013
    Inventors: Yingzhi BI, Kenneth Gordon CARSON, Giovanni CIANCHETTA, Michael Alan GREEN, Godwin KUMI, Zhi LIANG, Ying Jade LIU, Alan MAIN, Yulian ZHANG, Gregory Glenn ZIPP
  • MST1 kinase inhibitors and methods of their use
    Patent number: 8440652
    Abstract: Compounds for the inhibition of mammalian Ste20-like kinase 1 (MST1) are disclosed, along with compositions comprising them and methods of their use in the treatment, management or prevention of an inflammatory or autoimmune diseases or disorders.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: May 14, 2013
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: David John Augeri, Jeffrey Thomas Bagdanoff, Simon David Peter Baugh, Marianne Carlsen, Kenneth Gordon Carson, John Anthony Gilleran, Wei He, Tamas Oravecz, Konstantin Salojin, Leonard Sung