Abstract: Compounds are disclosed for the treatment, management and prevention of diseases and disorders affecting the bone. Particular compounds are potent inhibitors of Notum Pectinacetylesterase, and are of the formula: wherein E, G, Y, Z, R1, R2, and R3 are defined herein.

Abstract: Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.

Abstract: Compounds for the inhibition of mammalian Ste20-like kinase 1 (MST1) are disclosed, along with compositions comprising them and methods of their use in the treatment, management or prevention of an inflammatory or autoimmune diseases or disorders.

Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

Abstract: Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

Abstract: A shoulder rest for a violin, viola or like instrument is described which has a reduced risk and incidence of slippage and disengagement from the instrument by having provided thereon a cross-member adjacent to or displaced from the rest member of the shoulder rest, which cross-member is resilient and substantially stretch resistant and preferably linking two support members protruding from or associated with the rest member of the shoulder rest. When pressure is applied during use, the legs (or support members) of the shoulder rest do not splay and the shoulder rest remains in position. Feet or gripping members for attaching a shoulder rest to a violin reduced any detrimental impact to the sound quality of the violin caused by use of a shoulder rest by maintaining contact with the backplate only in the area of the backplate outside the inner purfling line.

Abstract: Compounds for the inhibition of mammalian Ste20-like kinase 1 (MST1) are disclosed, along with compositions comprising them and methods of their use in the treatment, management or prevention of an inflammatory or autoimmune diseases or disorders.

Abstract: Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.

Abstract: Compounds for the inhibition of mammalian Ste20-like kinase 1 (MST1) are disclosed, along with compositions comprising them and methods of their use in the treatment, management or prevention of an inflammatory or autoimmune diseases or disorders.

Abstract: The invention provides methods of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23.

Abstract: Compounds are disclosed for the treatment, management and prevention of diseases and disorders affecting the bone. Particular compounds are potent inhibitors of Notum Pectinacetylesterase, and are of the formula: wherein E, G, Y, Z, R1, R2, and R3 are defined herein.

Abstract: A shoulder rest for a violin, viola or like instrument is described which has a reduced risk and incidence of slippage and disengagement from the instrument by having provided thereon a cross-member adjacent to or displaced from the rest member of the shoulder rest, which cross-member is resilient and substantially stretch resistant and preferably linking two support members protruding from or associated with the rest member of the shoulder rest. When pressure is applied during use, the legs (or support members) of the shoulder rest do not splay and the shoulder rest remains in position. Feet or gripping members for attaching a shoulder rest to a violin reduced any detrimental impact to the sound quality of the violin caused by use of a shoulder rest by maintaining contact with the backplate only in the area of the backplate outside the inner purfling line.

Abstract: There is provided a method for leach extraction of copper/iron/sulphur ores and concentrates including leaching the mineral with an aqueous stream containing ferric ions and sulphuric acid in the presence of oxygen, the aqueous stream including a solution formed by reaction of basic ferric sulphate with excess suphuric acid. Integrated methods of forming and releaching basic ferric sulphate are also described.

Abstract: A computed radiography (CR) system for imaging an object is provided. The system includes a radiation source, a storage phosphor screen, an illumination source and a two dimensional imager. The radiation source is configured to irradiate the storage phosphor screen, and the storage phosphor screen is configured to store the radiation energy. The illumination source is configured to illuminate at least a sub-area of the storage phosphor screen to stimulate emission of photons from the storage phosphor screen. The two dimensional (2D) imager is configured to capture a two dimensional image from the storage phosphor screen using the stimulated emission photons. A method of reading a storage phosphor screen is also provided. The method includes illuminating at least a sub-area of the storage phosphor screen using an illumination source to stimulate emission of photons from the storage phosphor screen.

Abstract: A system for disposing of body fluids collected during surgery comprises a canister and an apparatus for emptying and cleaning the canister. The canister has a lid having an inlet port to receive body fluids during surgery and for insertion of a cleaning fluid sprayer during servicing, an outlet port with a suction tube extending into the canister for removal of fluids therefrom, and a vacuum port for the application of vacuum to the canister. The servicing unit is an appliance having a receiving compartment in which the canister is placed. A connector head in the servicing unit connects the canister to a source of cleaning fluid and to a conduit for evacuating the fluids in the canister through the suction tube and to a decontamination chamber, where they are brought into contact with a disinfecting fluid, and subsequently to a drain.

Abstract: A computed radiography (CR) system for imaging an object is provided. The system includes a radiation source, a storage phosphor screen, an illumination source and a two dimensional imager. The radiation source is configured to irradiate the storage phosphor screen, and the storage phosphor screen is configured to store the radiation energy. The illumination source is configured to illuminate at least a sub-area of the storage phosphor screen to stimulate emission of photons from the storage phosphor screen. The two dimensional (2D) imager is configured to capture a two dimensional image from the storage phosphor screen using the stimulated emission photons. A method of reading a storage phosphor screen is also provided. The method includes illuminating at least a sub-area of the storage phosphor screen using an illumination source to stimulate emission of photons from the storage phosphor screen.

Abstract: There is provided a method for leach extraction of copper/iron/sulphur ores and concentrates including leaching the mineral with an aqueous stream containing ferric ions and sulphuric acid in the presence of oxygen, the aqueous stream including a solution formed by reaction of basic ferric sulphate with excess suphuric acid. Integrated methods of forming and releaching basic ferric sulphate are also described.

Abstract: A computed radiography (CR) system for imaging an object is provided. The system includes a radiation source, a storage phosphor screen, an illumination source and a two dimensional imager. The radiation source is configured to irradiate the storage phosphor screen, and the storage phosphor screen is configured to store the radiation energy. The illumination source is configured to illuminate at least a sub-area of the storage phosphor screen to stimulate emission of photons from the storage phosphor screen. The two dimensional (2D) imager is configured to capture a two dimensional image from the storage phosphor screen using the stimulated emission photons. A method of reading a storage phosphor screen is also provided. The method includes illuminating at least a sub-area of the storage phosphor screen using an illumination source to stimulate emission of photons from the storage phosphor screen.

Abstract: In one embodiment, an apparatus for reversibly locking a lap belt portion of a safety belt webbing in a three-point, continuous loop seat belt system which includes a tongue assembly having the belt webbing routed therethrough, includes a cinch body adapted to mount to the tongue assembly, and a cam coupled to the cinch body and adapted to urge the belt webbing against the cinch body.