Patents by Inventor Kenneth Gregory Hull

Kenneth Gregory Hull has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibacterial piperdine derivatives
    Patent number: 8399489
    Abstract: Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
    Type: Grant
    Filed: February 16, 2006
    Date of Patent: March 19, 2013
    Assignee: Astrazeneca AB
    Inventors: Gregory Basarab, Brian Dangel, Paul Robert Fleming, Michael Barry Gravestock, Oluyinka Green, Sheila Irene Hauck, Pamela Hill, Kenneth Gregory Hull, George Mullen, Haihong Ni, Brian Sherer, Fei Zhou
  • PYRROLE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY
    Publication number: 20100286181
    Abstract: Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
    Type: Application
    Filed: August 16, 2007
    Publication date: November 11, 2010
    Applicant: ASTRAZENECA AB
    Inventors: Gregory Basarab, Pamela Hill, Kenneth Gregory Hull
  • ANTIBACTERIAL PIPERDINE DERIVATIVES
    Publication number: 20100179150
    Abstract: Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
    Type: Application
    Filed: February 16, 2006
    Publication date: July 15, 2010
    Applicant: ASTRAZENECA AB
    Inventors: Gregory Basarab, Brian Dangel, Paul Robert Fleming, Michael Barry Gravestock, Oluyinka Green, Sheila Irene Hauck, Pamela Hill, Kenneth Gregory Hull, George Mullen, Brian Sherer, Fei Zhou, Haihong Ni
  • HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20100137313
    Abstract: Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
    Type: Application
    Filed: October 2, 2009
    Publication date: June 3, 2010
    Inventors: Ann Boriack-Sjodin, Daniel Robert Carcanague, Daemian David Dussault, Holia Hatoum-Mokdad, Kenneth Gregory Hull, Georgine Ioannidis, John Irvin Manchester, Helen Maureen McGuire, David Charles McKinney, Suzanne Stokes
  • Pyrrol derivatives with antibacterial activity
    Patent number: 7709503
    Abstract: Compounds of Formula (1) and their pharmaceutically acceptable salts are described: Formula (1) Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: May 4, 2010
    Assignee: AstraZeneca AB
    Inventors: Oluyinka Morenike Green, Kenneth Gregory Hull, Haihong Ni, Sheila Irene Hauck, George Byron Mullen, Alexander Louis Breeze, Neil James Hales, David Timms
  • TRICYCLIC DERIVATIVES OF AZETIDINE AND PYRROLE WITH ANTIBACTERIAL ACTIVITY
    Publication number: 20090253671
    Abstract: Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
    Type: Application
    Filed: March 2, 2006
    Publication date: October 8, 2009
    Applicant: ASTRAZENECA AB
    Inventors: Shanta Bist, Sheila Irene Hauck, Kenneth Gregory Hull
  • N-alkanoylphenylalanine derivatives
    Publication number: 20040210051
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: April 21, 2004
    Publication date: October 21, 2004
    Inventors: Li Chen, Robert William Guthrie, Tai-Nang Huang, Achytharao Sidduri, Jefferson Wright Tilley, Kenneth Gregory Hull
  • N-alkanoylphenylalamine derivatives
    Patent number: 6806365
    Abstract: Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
    Type: Grant
    Filed: April 5, 2002
    Date of Patent: October 19, 2004
    Assignee: Hoffmann-La Rocher Inc.
    Inventors: Li Chen, Robert William Guthrie, Tai-Nang Huang, Achytharao Sidduri, Jefferson Wright Tilley, Kenneth Gregory Hull
  • N-alkanoylphenylalamine derivatives
    Publication number: 20030109459
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: April 5, 2002
    Publication date: June 12, 2003
    Inventors: Li Chen, Robert William Guthrie, Tai-Nang Huang, Achytharao Sidduri, Jefferson Wright Tilley, Kenneth Gregory Hull
  • Phenyl-keto-imidazolidine thioamide derivatives
    Patent number: 6479666
    Abstract: It has been discovered that compounds of the formula: and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated with chronic inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis, (MS), asthma, and inflammatory bowel disease (I BD).
    Type: Grant
    Filed: May 23, 2001
    Date of Patent: November 12, 2002
    Assignee: Hoffman-La Roche Inc.
    Inventors: Kenneth Gregory Hull, Achytharao Sidduri, Jefferson Wright Tilley
  • Diphenyl carbocyclic thioamide derivatives
    Patent number: 6458844
    Abstract: It has been discovered that compounds of the formula: and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated with chronic inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis, (MS), asthma, and inflammatory bowel disease (I BD).
    Type: Grant
    Filed: May 23, 2001
    Date of Patent: October 1, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Kenneth Gregory Hull, Achytharao Sidduri, Jefferson Wright Tilley
  • N-alkanoylphenylalanine derivatives
    Patent number: 6455550
    Abstract: Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: September 24, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Robert William Guthrie, Tai-Nang Huang, Achytharao Sidduri, Jefferson Wright Tilley, Kenneth Gregory Hull
  • Diphenyl heterocyclic thioamide derivatives
    Patent number: 6426348
    Abstract: It has been discovered that compounds of the formula: and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated with chronic inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis, (MS), asthma, and inflammatory bowel disease (I BD).
    Type: Grant
    Filed: May 23, 2001
    Date of Patent: July 30, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Kenneth Gregory Hull, Achytharao Sidduri, Jefferson Wright Tilley
  • Heterocyclic thioamide derivatives
    Patent number: 6423728
    Abstract: It has been discovered that compounds of the formula: and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are usefull in treating inflammation associated with chronic inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis, (MS), asthma, and inflammatory bowel disease (IBD).
    Type: Grant
    Filed: May 23, 2001
    Date of Patent: July 23, 2002
    Assignee: Hoffman-La Roche Inc.
    Inventors: Kenneth Gregory Hull, Achytharao Sidduri, Jefferson Wright Tilley
  • Thioamide derivatives
    Publication number: 20020028933
    Abstract: It has been discovered that compounds of the formula: 1
    Type: Application
    Filed: March 20, 2001
    Publication date: March 7, 2002
    Inventors: Kenneth Gregory Hull, Achytharao Sidduri, Jefferson W. Tilley
  • Thioamide derivatives
    Patent number: 6288267
    Abstract: It has been discovered that compounds of the formula: and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated with chronic inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis, (MS), asthma, and inflammatory bowel disease (I BD).
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: September 11, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Kenneth Gregory Hull, Achytharao Sidduri, Jefferson Wright Tilley
  • N-aroylphenylalanine derivative VCAM-1 inhibitors
    Patent number: 6229011
    Abstract: Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: May 8, 2001
    Assignee: Hoffman-La Roche Inc.
    Inventors: Li Chen, Robert William Guthrie, Tai-Nang Huang, Achyutharao Sidduri, Jefferson Wright Tilley, Kenneth Gregory Hull