Patents by Inventor Kenneth H. Pearce

Kenneth H. Pearce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystallized glucocorticoid receptor ligand binding domain polypeptide and screening methods employing same
    Patent number: 7238778
    Abstract: A method of modifying a test nuclear receptor (NR) polypeptide is disclosed. The method provides a test NR polypeptide sequence having a characteristic that is targeted for modification; aligning the test NR polypeptide sequence with at least one reference NR polypeptide sequence for which an X-ray structure is available; building a three-dimensional model for the test NR polypeptide using the three-dimensional coordinates of the X-ray structure(s) of at least one reference polypeptide and its sequence alignment with the test NR polypeptide sequence; examining the three-dimensional model of the test NR polypeptide sequence for characteristic differences with the reference polypeptide; and mutating at least one amino acid residue in the test NR polypeptide sequence at a characteristic difference, whereby the test NR polypeptide is modified.
    Type: Grant
    Filed: July 17, 2002
    Date of Patent: July 3, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Christopher J. Apolito, Randy K. Bledsoe, Millard H. Lambert, III, David D. McKee, Valerie Gail Montana, Kenneth H. Pearce, Thomas B. Stanley, Huaqiang Eric Xu, Christopher J Delves
  • FtsA
    Publication number: 20020048788
    Abstract: The invention provides FtsA polypeptides and polynucleotides encoding FtsA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FtsA polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: May 15, 2001
    Publication date: April 25, 2002
    Inventors: Kenneth H. Pearce, Kang Yan
  • Polynucleotides encoding Staphylococcus aureus FtsA polypeptide
    Patent number: 6251633
    Abstract: The invention provides FtsA polypeptide and polynucleotides encoding FtsA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FtsA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: June 26, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Kenneth H Pearce, Jr., Kang Yan
  • Div1b
    Patent number: 6060055
    Abstract: The invention provides Div1b polypeptides and DNA (RNA) encoding Div1b polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Div1b polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 4, 1999
    Date of Patent: May 9, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: John Edward Hodgson, David John Payne, Stewart Campbell Pearson, Kenneth H. Pearce, Jr.
  • Div1b
    Patent number: 6022706
    Abstract: The invention provides Divlb polypeptides and DNA (RNA) encoding Divlb polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Divlb polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 27, 1997
    Date of Patent: February 8, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: John Edward Hodgson, David John Payne, Stewart Campbell Pearson, Kenneth H Pearce, Jr.